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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4134656","sourcedb":"PMC","sourceid":"4134656","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4134656","text":"Unlike vascular malformations, IH have a characteristic natural course; a rapid proliferative phase in infancy which is followed by a gradual involutional phase over the next several years of life. Chang et al. in their study on growth characteristics of IH in 433 patients observed that in most IH growth occurred before 5 months of age. However, segmental haemangiomas showed a trend toward higher growth rate after 6 months of age. Deeper IH exhibited a 1-month delay in onset and also showed sustained growth when compared to superficial IH.[3] This study highlighted that the initial few weeks up to five months is the crucial period in IH growth. Complications such as ulceration, distortion of vital structures and skin disfigurement are also expected to occur during this critical period. Hence, the treating dermatologists and paediatricians should be aware of these facts which will be useful in the clinical decision making.[3]","tracks":[{"project":"2_test","denotations":[{"id":"25136206-18676554-58659520","span":{"begin":546,"end":547},"obj":"18676554"},{"id":"25136206-18676554-58659521","span":{"begin":936,"end":937},"obj":"18676554"}],"attributes":[{"subj":"25136206-18676554-58659520","pred":"source","obj":"2_test"},{"subj":"25136206-18676554-58659521","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9397ec","default":true}]}]}}