PMC:4134656 / 17803-18710 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4134656","sourcedb":"PMC","sourceid":"4134656","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4134656","text":"Oral propranolol is known to be effective during the rapid proliferative phase but there are several reports which have shown involution where propranolol was initiated at the end of growth phase or later.[27313236] Hogeling et al., in their trial of 40 children with IH, included a combination of growing, plateaued and involuting lesions. The authors noted a steady decrease in percentage volume for all weeks in the propranolol group compared to placebo.[35] This suggests that propranolol can be used at all stages of IH. Schupp et al.[32] and Zvulunov et al.[36] reported good clinical improvement with propranolol for IH beyond proliferative phase. However, Holmes et al. did not observe any improvement in children with IH in whom the propranolol was started after 9 months of age.[39] Hence, large prospective studies are needed to confirm the efficacy of propranolol in older age group of children.","tracks":[{"project":"2_test","denotations":[{"id":"25136206-23405852-58659575","span":{"begin":206,"end":208},"obj":"23405852"},{"id":"25136206-23278381-58659576","span":{"begin":206,"end":210},"obj":"23278381"},{"id":"25136206-21995836-58659577","span":{"begin":206,"end":212},"obj":"21995836"},{"id":"25136206-21362031-58659578","span":{"begin":206,"end":214},"obj":"21362031"},{"id":"25136206-21788220-58659579","span":{"begin":458,"end":460},"obj":"21788220"},{"id":"25136206-21995836-58659580","span":{"begin":540,"end":542},"obj":"21995836"},{"id":"25136206-21362031-58659581","span":{"begin":564,"end":566},"obj":"21362031"}],"attributes":[{"subj":"25136206-23405852-58659575","pred":"source","obj":"2_test"},{"subj":"25136206-23278381-58659576","pred":"source","obj":"2_test"},{"subj":"25136206-21995836-58659577","pred":"source","obj":"2_test"},{"subj":"25136206-21362031-58659578","pred":"source","obj":"2_test"},{"subj":"25136206-21788220-58659579","pred":"source","obj":"2_test"},{"subj":"25136206-21995836-58659580","pred":"source","obj":"2_test"},{"subj":"25136206-21362031-58659581","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecb0","default":true}]}]}}