
PMC:4134656 / 16762-17802
Annnotations
The duration of therapy depends on the morphological type of haemangioma, extent of involvement and the treatment indications. Hogeling et al., based on their randomized controlled trial (RCT), suggest a treatment course of at least 6 months which could be modified according to the morphological subtypes, for example deep and mixed IH may continue to proliferate up to 1 year of age and hence, treatment may be extended up to this period.[35] The mean duration of treatment varies from 6 to 10 months. In a recent study on the propranolol treatment in complicated IH, the authors have used the drug for a mean duration of 10.7 months. In the deep and mixed type haemangiomas, they continued the treatment until the age of 12-16 months, in ulcerated lesions up to 9-12 months and in deep peri-orbital and airway lesions up to 15-18 months of age.[31] Marqueling et al. in their meta analysis of 1264 children in 41 studies found that the propranolol was administered for an average duration of 6.4 months (range, 1 weeks to 15 months).[27]