PMC:4134656 / 16168-16761 JSONTXT

{"project":"2_test","denotations":[{"id":"25136206-23266923-58659567","span":{"begin":107,"end":108},"obj":"23266923"},{"id":"25136206-23278381-58659568","span":{"begin":370,"end":372},"obj":"23278381"},{"id":"25136206-22244411-58659569","span":{"begin":432,"end":434},"obj":"22244411"},{"id":"25136206-23266923-58659570","span":{"begin":589,"end":590},"obj":"23266923"},{"id":"25136206-23405852-58659571","span":{"begin":589,"end":592},"obj":"23405852"}],"text":"In the recent consensus conference report on haemangioma, a target dose of 1-3 mg/kg has been recommended.[7] However, many researchers advocate a dose of 2 mg/kg/day. Hermans et al. in their large prospective study used a higher dose of 3 mg/kg/day in patients with haemangiomas causing airway obstruction or associated with repeated severe bleeding due to ulceration.[31] Few authors have also used a maximum dose of 4 mg/kg/day.[14] It is usually administered at a low starting dose of 0.5 to 1 mg/kg/day which is gradually escalated to the optimal dose over a period of days to weeks.[727]"}