PMC:4134656 / 15338-16167 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4134656","sourcedb":"PMC","sourceid":"4134656","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4134656","text":"Ideally, propranolol should be initiated immediately once the decision is taken. Although there is no published evidence that early start of propranolol therapy results in less deforming residual skin changes, it is always better to start the treatment as early as possible before rapid proliferation of the tumour. A recent meta-analysis (including 1264 children in 41 studies) showed that oral propranolol was initiated at a mean age of 6.6 months (range from 3 days to 10 years).[27] In a single-centre prospective study of 174 children, propranolol was administered at a mean age of 4.8 months (0.9-29 months).[31] In an another recent review of 28 studies on IH, propranolol was initiated during infancy at a mean age of 4.5 months (range, 27 days-12 months). In 11 cases, propranolol was started after 12 months of age.[26]","tracks":[{"project":"2_test","denotations":[{"id":"25136206-23405852-58659564","span":{"begin":483,"end":485},"obj":"23405852"},{"id":"25136206-23278381-58659565","span":{"begin":615,"end":617},"obj":"23278381"},{"id":"25136206-22097156-58659566","span":{"begin":826,"end":828},"obj":"22097156"}],"attributes":[{"subj":"25136206-23405852-58659564","pred":"source","obj":"2_test"},{"subj":"25136206-23278381-58659565","pred":"source","obj":"2_test"},{"subj":"25136206-22097156-58659566","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93d3ec","default":true}]}]}}