PMC:4129407 / 19515-20158 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4129407","sourcedb":"PMC","sourceid":"4129407","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4129407","text":"Previous studies comparing PsA and PsC have suggested that HLA-C∗06:02 shows increased PsC risk but decreased PsA risk,13,14 and our study replicated this finding in a concordant directional effect (p = 9.4 × 10−6 for PsA versus PsC individuals). However, the differential impact of HLA-C∗06:02 on PsA and PsC risk disappeared after we conditioned on HLA-B amino acid position 45 (p = 0.12), suggesting that this reduced effect was the result of linkage to HLA-B. In contrast, the effect of HLA-B amino acid position 45 with respect to PsA versus PsC risk retained significance even after we conditioned on HLA-C∗06:02 (pomnibus = 2.2 × 10−7).","tracks":[{"project":"2_test","denotations":[{"id":"25087609-21900282-2044428","span":{"begin":122,"end":124},"obj":"21900282"},{"id":"25087609-22586163-2044428","span":{"begin":122,"end":124},"obj":"22586163"}],"attributes":[{"subj":"25087609-21900282-2044428","pred":"source","obj":"2_test"},{"subj":"25087609-22586163-2044428","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9397ec","default":true}]}]}}