PMC:4129407 / 18487-19514 JSONTXT

{"project":"2_test","denotations":[{"id":"25087609-23749187-2044427","span":{"begin":766,"end":768},"obj":"23749187"}],"text":"Surprisingly, when we directly assessed comparative risk between PsA and PsC subjects, we found the lowest p value of the nominal association signal at HLA-B amino acid position 45 (pomnibus = 2.2 × 10−11; Figures 1D and 2F) rather than at HLA-C alleles. After conditioning on HLA-B amino acid position 45, or all classical HLA-B alleles, we observed no significant association in the MHC region (p \u003e 5.0 × 10−8; Figures 2G and 3E). Of the HLA-B amino acid residues at position 45, HLA-B Glu45 increased PsA susceptibility in comparison to PsC susceptibility (OR = 1.46, 95% CI = 1.31–1.62, p = 2.9 × 10−12; Table 2; Table S2). Examining the classical alleles, we noted that HLA-B∗27, a risk allele for another arthritic disease, ankylosing spondylitis (MIM 106300),33 demonstrated the lowest p value for PsA versus PsC association (p = 1.2 × 10−4; Figure 4; Table S4) but much less significantly than HLA-B Glu45. We note that HLA-B∗27, along with HLA-B∗38, HLA-B∗39, and a number of other alleles, carries Glu at position 45."}