PMC:4129407 / 14397-15448
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4129407","sourcedb":"PMC","sourceid":"4129407","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4129407","text":"Unsurprisingly, when we tested the imputed variants in the MHC region for overall PsV risk (PsV-affected versus control individuals), the top association signal mapped to HLA-C (Figures 1A and 2A; Table S2). The most strongly associated variant was the classical HLA-C∗06:02 allele (p = 1.7 × 10−364), highly consistent with previous reports that HLA-C∗06:02 has the strongest association with PsV risk.7–12,17,18 We observed that no HLA-C amino acid polymorphism was more strongly associated than HLA-C∗06:02 (the smallest p value, pomnibus = 4.5 × 10−250, was at HLA-C amino acid position 156; Figure 3A). When conditioning on HLA-C∗06:02, we observed the top association signal at the four-digit classical allele of HLA-C∗12:03 (p = 2.5 × 10−25). After conditioning on HLA-C∗06:02 and HLA-C∗12:03, we found that no association exceeded the genome-wide significance threshold for the HLA-C variants (p \u003e 5.0 × 10−8). These results suggest that multiple classical HLA-C alleles, exemplified by HLA-C∗06:02, explain the influence of HLA-C on PsV risk.","tracks":[{"project":"2_test","denotations":[{"id":"25087609-19169254-2044425","span":{"begin":411,"end":413},"obj":"19169254"},{"id":"25087609-20953190-2044425","span":{"begin":411,"end":413},"obj":"20953190"},{"id":"25087609-20953188-2044425","span":{"begin":411,"end":413},"obj":"20953188"},{"id":"25087609-20953186-2044425","span":{"begin":411,"end":413},"obj":"20953186"},{"id":"25087609-20953189-2044425","span":{"begin":411,"end":413},"obj":"20953189"},{"id":"25087609-23143594-2044425","span":{"begin":411,"end":413},"obj":"23143594"},{"id":"25087609-19680446-2044425","span":{"begin":411,"end":413},"obj":"19680446"},{"id":"25087609-22914738-2044425","span":{"begin":411,"end":413},"obj":"22914738"}],"attributes":[{"subj":"25087609-19169254-2044425","pred":"source","obj":"2_test"},{"subj":"25087609-20953190-2044425","pred":"source","obj":"2_test"},{"subj":"25087609-20953188-2044425","pred":"source","obj":"2_test"},{"subj":"25087609-20953186-2044425","pred":"source","obj":"2_test"},{"subj":"25087609-20953189-2044425","pred":"source","obj":"2_test"},{"subj":"25087609-23143594-2044425","pred":"source","obj":"2_test"},{"subj":"25087609-19680446-2044425","pred":"source","obj":"2_test"},{"subj":"25087609-22914738-2044425","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93bbec","default":true}]}]}}