PMC:4129407 / 12809-13811 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4129407","sourcedb":"PMC","sourceid":"4129407","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4129407","text":"We tested whether the effect sizes of m classical four-digit alleles of the HLA gene had concordant risks between PsA and PsC, as described elsewhere.26 For each of the two compared phenotypes (PsA-affected versus control individuals and PsC-affected versus control individuals), we calculated multivariate odds ratios (ORs) of m − 1 alleles by including them as binary independent variables in the regression model, where the most frequent allele was excluded as a reference. Let βPsA,1, …, βPsA,m−1 and vPsA,1, …, vPsA,m−1 be the multivariate log ORs and their variances, respectively, in PsA-affected versus control individuals, and let βPsC,1, …, βPsC,m−1 and vPsC,1, …, vPsC,m−1 be those in PsC-affected versus control individuals. We evaluated discordance of the effect sizes between the compared phenotypes (pheterogeneity) by testing the statistic∑i=1m−1(βPsA,i−βPsC,i)2vPsA,i+vPsC,i,which follows a χ2 distribution with m − 1 degrees of freedom under the null hypothesis of concordant effects.","tracks":[{"project":"2_test","denotations":[{"id":"25087609-24656864-2044423","span":{"begin":150,"end":152},"obj":"24656864"}],"attributes":[{"subj":"25087609-24656864-2044423","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#b8ec93","default":true}]}]}}