PMC:4129400 / 45856-46626 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4129400","sourcedb":"PMC","sourceid":"4129400","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4129400","text":"We utilized the MWA approach to screen more than 4,300 antibodies. From this screening effort we identified 441 antibodies against 391 unique proteins that we used for subsequent quantification of relative protein levels within a population of YRI LCLs. We performed comparative analysis of the relationship between genetic variation and between subsets of the transcriptome and proteome. We replicated and functionally validated a significant trans pQTL from our proteomic association analyses. Because of the difficulties in comparison of existing large-scale genomic and proteomic data sets, our study represents one of the first to examine large-scale relationships between genome variation, mRNA expression, protein levels, and protein modifications in human cells.","tracks":[]}