PMC:4110358 / 14980-16120 JSONTXT

{"project":"2_test","denotations":[{"id":"25097708-3839105-132809980","span":{"begin":615,"end":617},"obj":"3839105"},{"id":"25097708-18419726-132809981","span":{"begin":1136,"end":1138},"obj":"18419726"}],"text":"Drugs used in anaesthesia\nThe main indication for the use of naloxone is to reverse the effects of opioids, for example in narcotic agent intoxication or awaking from sedation after anaesthesia. Naloxone is also a drug that is sometimes used in situations very different from its main indications. It was found, for example, that it can be effective in cases of aggravating itchiness in liver disorders with cholestasis. Naloxone has the ability to accelerate intestinal transit time with partial normalisation of the electrogastrographic record, as demonstrated in the case of gastrointestinal pseudo-obstruction [27]. A study done with healthy volunteers did not show any significant effect of naloxone on GMA, or on the rate of gastric emptying [28].\nAnother drug often used in anaesthesia with documented significant effect on the myoelectric activity of the stomach is fentanyl, a painkiller drug belonging to the family of opioid analgesics. Approximately half of the patients undergoing anaesthesia with fentanyl showed a significant decrease in both the dominant frequency and dominant power in the electrogastrographic record [29]."}

{"project":"NEUROSES","denotations":[{"id":"T311","span":{"begin":0,"end":5},"obj":"CHEBI_23888"},{"id":"T312","span":{"begin":214,"end":218},"obj":"CHEBI_23888"},{"id":"T313","span":{"begin":762,"end":766},"obj":"CHEBI_23888"},{"id":"T314","span":{"begin":897,"end":901},"obj":"CHEBI_23888"},{"id":"T315","span":{"begin":61,"end":69},"obj":"CHEBI_7459"},{"id":"T316","span":{"begin":195,"end":203},"obj":"CHEBI_7459"},{"id":"T317","span":{"begin":421,"end":429},"obj":"CHEBI_7459"},{"id":"T318","span":{"begin":696,"end":704},"obj":"CHEBI_7459"},{"id":"T319","span":{"begin":123,"end":131},"obj":"CHEBI_35482"},{"id":"T320","span":{"begin":479,"end":483},"obj":"PATO_0001309"},{"id":"T321","span":{"begin":479,"end":483},"obj":"PATO_0000165"},{"id":"T322","span":{"begin":657,"end":660},"obj":"CHEBI_52027"},{"id":"T323","span":{"begin":723,"end":727},"obj":"PATO_0001470"},{"id":"T324","span":{"begin":723,"end":727},"obj":"PATO_0000161"},{"id":"T325","span":{"begin":874,"end":882},"obj":"CHEBI_119915"},{"id":"T326","span":{"begin":1011,"end":1019},"obj":"CHEBI_119915"},{"id":"T327","span":{"begin":1071,"end":1080},"obj":"PATO_0000044"},{"id":"T328","span":{"begin":1094,"end":1099},"obj":"PATO_0001024"}],"text":"Drugs used in anaesthesia\nThe main indication for the use of naloxone is to reverse the effects of opioids, for example in narcotic agent intoxication or awaking from sedation after anaesthesia. Naloxone is also a drug that is sometimes used in situations very different from its main indications. It was found, for example, that it can be effective in cases of aggravating itchiness in liver disorders with cholestasis. Naloxone has the ability to accelerate intestinal transit time with partial normalisation of the electrogastrographic record, as demonstrated in the case of gastrointestinal pseudo-obstruction [27]. A study done with healthy volunteers did not show any significant effect of naloxone on GMA, or on the rate of gastric emptying [28].\nAnother drug often used in anaesthesia with documented significant effect on the myoelectric activity of the stomach is fentanyl, a painkiller drug belonging to the family of opioid analgesics. Approximately half of the patients undergoing anaesthesia with fentanyl showed a significant decrease in both the dominant frequency and dominant power in the electrogastrographic record [29]."}