PMC:4067558 / 49368-50108 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4067558","sourcedb":"PMC","sourceid":"4067558","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4067558","text":"(C–D) Pattern of increased burden as the number of brain-expressed genes affected by deletions (C) or duplications (D) increased. The percentages of affected and control subjects with CNVs overlapping genes are shown for deletions and duplications separately. For estimating the expected ORs (stars), a logit model of case status (affected or control) was fit to covariates, namely CNV status, the number of genes covered by each CNV, and their average brain expression levels (neocortex, BrainSpan). See Tables S11A–S11E for the results of alternative models, all of which showed that ASD risk increased as a function of the number of brain-expressed genes affected by a CNV, even after within-subject dependency of CNVs was accounted for.","tracks":[]}