PMC:4067558 / 3045-3560 JSONTXT

{"project":"2_test","denotations":[{"id":"24768552-22463983-2047083","span":{"begin":214,"end":216},"obj":"22463983"},{"id":"24768552-21129364-2047084","span":{"begin":284,"end":286},"obj":"21129364"},{"id":"24768552-23259942-2047085","span":{"begin":439,"end":441},"obj":"23259942"}],"text":"Interestingly, CNV testing and exome sequencing have so far yielded mostly nonoverlapping genes, which might reflect different mutational mechanisms, although they might still perturb connected biological pathways.17 Although numerous ASD-associated loci have been recognized to date,18 they only account for a small fraction of the overall estimated heritability, consistent with predictions that there might be ∼1,000 loci underlying ASD19 and that many associated genes and risk variants remain to be identified."}