PMC:4024607 / 7359-9534 JSONTXT

{"project":"NEUROSES","denotations":[{"id":"T149","span":{"begin":431,"end":434},"obj":"CHEBI_17842"},{"id":"T150","span":{"begin":431,"end":434},"obj":"CHEBI_81567"},{"id":"T151","span":{"begin":570,"end":573},"obj":"PATO_0000011"},{"id":"T152","span":{"begin":570,"end":573},"obj":"CHEBI_84123"},{"id":"T153","span":{"begin":1135,"end":1138},"obj":"CHEBI_16044"},{"id":"T154","span":{"begin":1357,"end":1360},"obj":"CHEBI_16044"},{"id":"T155","span":{"begin":1832,"end":1835},"obj":"CHEBI_16044"},{"id":"T156","span":{"begin":1135,"end":1138},"obj":"CHEBI_16811"},{"id":"T157","span":{"begin":1357,"end":1360},"obj":"CHEBI_16811"},{"id":"T158","span":{"begin":1832,"end":1835},"obj":"CHEBI_16811"},{"id":"T159","span":{"begin":1135,"end":1138},"obj":"CHEBI_16643"},{"id":"T160","span":{"begin":1357,"end":1360},"obj":"CHEBI_16643"},{"id":"T161","span":{"begin":1832,"end":1835},"obj":"CHEBI_16643"},{"id":"T162","span":{"begin":1226,"end":1235},"obj":"PATO_0000427"},{"id":"T163","span":{"begin":1528,"end":1535},"obj":"CHEBI_16236"},{"id":"T164","span":{"begin":1528,"end":1535},"obj":"CHEBI_30879"},{"id":"T165","span":{"begin":1961,"end":1965},"obj":"PATO_0002316"},{"id":"T166","span":{"begin":2000,"end":2007},"obj":"CHEBI_49713"},{"id":"T167","span":{"begin":2000,"end":2007},"obj":"CHEBI_30145"},{"id":"T168","span":{"begin":2018,"end":2026},"obj":"PATO_0000380"},{"id":"T169","span":{"begin":2063,"end":2073},"obj":"CHEBI_5118"},{"id":"T170","span":{"begin":2082,"end":2092},"obj":"CHEBI_9123"},{"id":"T171","span":{"begin":2103,"end":2113},"obj":"CHEBI_3723"},{"id":"T172","span":{"begin":2159,"end":2174},"obj":"CHEBI_35469"}],"text":"Patients\nA total of 162 women with BPD were invited to take part in the SKIP project. Of these individuals, 14 declined to join the study, 41 were excluded due to not fulfilling inclusion criteria or to fulfilling exclusion criteria and one completed suicide before joining the study. Thus, out of 162 women, 106 (65%) took part in the SKIP study. We obtained laboratory data for 97 of 106 individuals; 92 patients were euthyroid (TSH reference range: 0.4–3.5 mE/l, Karolinska University Hospital) and thus included in the statistical analyses described below.\nThe mean age of the patients was 29.5 years (SD=7.6; range 19–50). The participants were interviewed by a trained psychiatrist, using the SCID I research version interview to establish the DSM–IV diagnoses (First, Spitzer, Gibbon, \u0026 Williams, 1997). Trained clinical psychologists established Axis II diagnoses by DIP–I interviews (Ottosson et al., 1995). All self-rating scales were completed under the supervision of a research nurse. 90 (98%) of the participants had at least one current Axis I psychiatric diagnosis. Among the Axis I diagnoses, 78 (85%) of the patients met the criteria for mood disorders (unipolar major depressive disorder, single episode or recurrent, bipolar disorder, depressed or dysthymic disorder), 76 (83%) for anxiety disorders. Forty nine out of 92 (53%) patients met the criteria of PTSD. 24 (26%) had a comorbid eating disorder; of whom 16 (17%) with bulimia and eight (9%) with anorexia nervosa. Eight women (9%) had a diagnosis of alcohol abuse. Fifty women had an additional personality disorder (PD); avoidant PD (n=24), paranoid PD (n=15), obsessive–compulsive PD (n=12), histrionic PD (n=10), dependent PD (n=9), narcissistic PD (n=4). 22 (24%) women had three or more personality disorders. The criteria for conduct disorder were met in seven of the women. Medication records were obtained for 68 (74%) of the patients, of whom seven patients were medication-free. Three patients were treated with lithium. The most frequent medications were venlafaxin (n=12), fluoxetine (n=11), sertraline (n=9) and citalopram (n=4). Two patients had a combination of two antidepressants."}