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{"project":"2_test","denotations":[{"id":"15061865-9247267-12857725","span":{"begin":168,"end":170},"obj":"9247267"},{"id":"15061865-11323267-12857726","span":{"begin":419,"end":421},"obj":"11323267"},{"id":"15061865-10789947-12857726","span":{"begin":419,"end":421},"obj":"10789947"}],"text":"In an effort to establish the contribution of dopamine D2 receptor-mediated signaling to associative and non-spatial reversal learning in adult mice, we compared mice [23] that had developed in the complete absence of all functional dopamine D2 receptors (D2R-/-) to wild-type littermates (D2R+/+) in a go/no-go operant learning procedure that measures primary reinforcement, sensory processing, and reversal learning [17-19]. Here we report that dopamine D2R-mediated signaling must be intact if a mouse is to efficiently learn to associate a food reinforcer with a specific odor and then adaptively disengage inappropriate behavioral strategies following the reversal of reinforcement contingencies."}