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signaling is mediated at the cellular level by two major subclasses of G-protein coupled receptors that are referred to as D-1 like (D1aR, D1b/5R) or D-2 like (D2R, D3R, D4R) [12,13]. Although individual genes code for each dopamine receptor subtype, there is considerable pharmacological overlap between D1-like and D2-like receptors. Several studies have used pharmacological manipulations to investigate the contribution of dopamine receptor subtypes in various stages of associative learning [1,2,14]. Currently it is held that excitatory dopamine D1Rs mediate the acquisition and expression of several conditioned behaviors involving food reinforcers [e.g. [6,7]] as well as responding for conditioned cues predictive of cocaine delivery [9] – consistent with the interpretation that D1R mediated signaling might modulate the maintenance of stimulus-response outcomes. Despite a growing literature demonstrating disrupted associative learning following acute manipulations of dopamine D1R signaling during acquisition of associative learning tasks with food [e.g. [6,7]], the actual contribution of D2R-mediated signaling on acquisition and maintenance of associative learning in rodents is unresolved."}

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Despite a growing literature demonstrating disrupted associative learning following acute manipulations of dopamine D1R signaling during acquisition of associative learning tasks with food [e.g. [6,7]], the actual contribution of D2R-mediated signaling on acquisition and maintenance of associative learning in rodents is unresolved."}

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{"project":"2_test","denotations":[{"id":"15061865-8494342-12857699","span":{"begin":185,"end":187},"obj":"8494342"},{"id":"15061865-9858756-12857700","span":{"begin":506,"end":507},"obj":"9858756"},{"id":"15061865-12445713-12857701","span":{"begin":508,"end":509},"obj":"12445713"},{"id":"15061865-11257908-12857702","span":{"begin":510,"end":512},"obj":"11257908"},{"id":"15061865-12629161-12857703","span":{"begin":672,"end":673},"obj":"12629161"},{"id":"15061865-11027236-12857704","span":{"begin":674,"end":675},"obj":"11027236"},{"id":"15061865-11351937-12857705","span":{"begin":753,"end":754},"obj":"11351937"},{"id":"15061865-12629161-12857706","span":{"begin":1079,"end":1080},"obj":"12629161"},{"id":"15061865-11027236-12857707","span":{"begin":1081,"end":1082},"obj":"11027236"}],"text":"Dopamine signaling is mediated at the cellular level by two major subclasses of G-protein coupled receptors that are referred to as D-1 like (D1aR, D1b/5R) or D-2 like (D2R, D3R, D4R) [12,13]. Although individual genes code for each dopamine receptor subtype, there is considerable pharmacological overlap between D1-like and D2-like receptors. Several studies have used pharmacological manipulations to investigate the contribution of dopamine receptor subtypes in various stages of associative learning [1,2,14]. Currently it is held that excitatory dopamine D1Rs mediate the acquisition and expression of several conditioned behaviors involving food reinforcers [e.g. [6,7]] as well as responding for conditioned cues predictive of cocaine delivery [9] – consistent with the interpretation that D1R mediated signaling might modulate the maintenance of stimulus-response outcomes. Despite a growing literature demonstrating disrupted associative learning following acute manipulations of dopamine D1R signaling during acquisition of associative learning tasks with food [e.g. [6,7]], the actual contribution of D2R-mediated signaling on acquisition and maintenance of associative learning in rodents is unresolved."}