PMC:400732 / 21160-22592 JSONTXT

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In the course of associative learning, striatal synapses [38] receive experience-driven gain [7], thus permitting newly established reinforcement-mediated signals to traverse ascending efferents en route to the frontal cortex, completing a functional limbic/motor circuit [39-41]. Possibly, the lack of dopamine D2R-mediated signaling prevents refinement of the corticostriatal reinforcement circuits in the brains of the D2R-/- mice, thus impairing their ability to form S+/S- contingencies and disengage inappropriate dopamine D1R-mediated associative responding when unexpected consequences to goal-directed behaviors happened. Consequently, we are compelled to conclude that the perseverative performance deficits demonstrated by the D2R-/- mice in the tasks used in the present study reveal a previously unreported role for D2Rs in associative and reversal 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