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Id Subject Object Predicate Lexical cue
T4023 11-13 IN denotes In
T4024 29-35 VBD denotes sought
T4025 14-18 DT denotes this
T4026 19-24 NN denotes study
T4027 24-26 , denotes ,
T4028 26-28 PRP denotes we
T4029 36-38 TO denotes to
T4030 39-48 VB denotes determine
T4031 49-52 DT denotes the
T4032 53-65 NN denotes contribution
T4033 66-68 IN denotes of
T4034 69-77 NN denotes dopamine
T4035 78-80 NN denotes D2
T4036 81-89 NN denotes receptor
T4037 90-98 VBN denotes mediated
T4038 89-90 HYPH denotes -
T4039 99-108 NN denotes signaling
T4040 109-111 IN denotes to
T4041 112-115 DT denotes the
T4042 124-130 NNS denotes stages
T4043 116-123 JJ denotes various
T4044 131-133 IN denotes of
T4045 134-145 JJ denotes associative
T4046 159-167 NN denotes learning
T4047 146-149 CC denotes and
T4048 150-158 NN denotes reversal
T4049 167-168 . denotes .
T4050 168-425 sentence denotes D2R-/- mice demonstrated that they were capable of learning to locate and consume food pellets, indicating that their locomotor behavior was not detectably disrupted and their primary motivation to obtain a natural reinforcer (food pellet) was undisturbed.
T4051 169-172 NN denotes D2R
T4052 176-180 NNS denotes mice
T4053 172-173 SYM denotes -
T4054 173-174 HYPH denotes /
T4055 174-175 SYM denotes -
T4056 181-193 VBD denotes demonstrated
T4057 194-198 IN denotes that
T4058 204-208 VBD denotes were
T4059 199-203 PRP denotes they
T4060 209-216 JJ denotes capable
T4061 217-219 IN denotes of
T4062 220-228 VBG denotes learning
T4063 229-231 TO denotes to
T4064 232-238 VB denotes locate
T4065 239-242 CC denotes and
T4066 243-250 VB denotes consume
T4067 251-255 NN denotes food
T4068 256-263 NNS denotes pellets
T4069 263-265 , denotes ,
T4070 265-275 VBG denotes indicating
T4071 276-280 IN denotes that
T4072 325-334 VBN denotes disrupted
T4073 281-286 PRP$ denotes their
T4074 297-305 NN denotes behavior
T4075 287-296 NN denotes locomotor
T4076 306-309 VBD denotes was
T4077 310-313 RB denotes not
T4078 314-324 RB denotes detectably
T4079 335-338 CC denotes and
T4080 339-344 PRP$ denotes their
T4081 353-363 NN denotes motivation
T4082 345-352 JJ denotes primary
T4083 409-412 VBD denotes was
T4084 364-366 TO denotes to
T4085 367-373 VB denotes obtain
T4086 374-375 DT denotes a
T4087 384-394 NN denotes reinforcer
T4088 376-383 JJ denotes natural
T4089 395-396 -LRB- denotes (
T4090 396-400 NN denotes food
T4091 401-407 NN denotes pellet
T4092 407-408 -RRB- denotes )
T4093 413-424 JJ denotes undisturbed
T4094 424-425 . denotes .
T4095 425-693 sentence denotes Rather, the impaired ability of D2R-/- mice to assign appropriate discriminative stimulus relationships in an operant discrimination task argues that D2R-mediated signaling contributes to the neuronal processes involved in attaching salience to environmental stimuli.
T4096 426-432 RB denotes Rather
T4097 564-570 VBZ denotes argues
T4098 432-434 , denotes ,
T4099 434-437 DT denotes the
T4100 447-454 NN denotes ability
T4101 438-446 JJ denotes impaired
T4102 455-457 IN denotes of
T4103 458-461 NN denotes D2R
T4104 465-469 NNS denotes mice
T4105 461-462 SYM denotes -
T4106 462-463 HYPH denotes /
T4107 463-464 SYM denotes -
T4108 470-472 TO denotes to
T4109 473-479 VB denotes assign
T4110 480-491 JJ denotes appropriate
T4111 516-529 NNS denotes relationships
T4112 492-506 JJ denotes discriminative
T4113 507-515 NN denotes stimulus
T4114 530-532 IN denotes in
T4115 533-535 DT denotes an
T4116 559-563 NN denotes task
T4117 536-543 NN denotes operant
T4118 544-558 NN denotes discrimination
T4119 571-575 IN denotes that
T4120 599-610 VBZ denotes contributes
T4121 576-579 NN denotes D2R
T4122 580-588 VBN denotes mediated
T4123 579-580 HYPH denotes -
T4124 589-598 NN denotes signaling
T4125 611-613 IN denotes to
T4126 614-617 DT denotes the
T4127 627-636 NNS denotes processes
T4128 618-626 JJ denotes neuronal
T4129 637-645 VBN denotes involved
T4130 646-648 IN denotes in
T4131 649-658 VBG denotes attaching
T4132 659-667 NN denotes salience
T4133 668-670 IN denotes to
T4134 671-684 JJ denotes environmental
T4135 685-692 NNS denotes stimuli
T4136 692-693 . denotes .
T4137 693-911 sentence denotes The deficient capacity of D2R-/- mice to disengage inappropriate decision strategies strongly argues that mesolimbic dopamine signaling, mediated by dopamine D2Rs is essential for efficient reversal learning to occur.
T4138 694-697 DT denotes The
T4139 708-716 NN denotes capacity
T4140 698-707 JJ denotes deficient
T4141 788-794 VBZ denotes argues
T4142 717-719 IN denotes of
T4143 720-723 NN denotes D2R
T4144 727-731 NNS denotes mice
T4145 723-724 SYM denotes -
T4146 724-725 HYPH denotes /
T4147 725-726 SYM denotes -
T4148 732-734 TO denotes to
T4149 735-744 VB denotes disengage
T4150 745-758 JJ denotes inappropriate
T4151 768-778 NNS denotes strategies
T4152 759-767 NN denotes decision
T4153 779-787 RB denotes strongly
T4154 795-799 IN denotes that
T4155 857-859 VBZ denotes is
T4156 800-810 JJ denotes mesolimbic
T4157 820-829 NN denotes signaling
T4158 811-819 NN denotes dopamine
T4159 829-831 , denotes ,
T4160 831-839 VBN denotes mediated
T4161 840-842 IN denotes by
T4162 843-851 NN denotes dopamine
T4163 852-856 NNS denotes D2Rs
T4164 860-869 JJ denotes essential
T4165 870-873 IN denotes for
T4166 905-910 VB denotes occur
T4167 874-883 JJ denotes efficient
T4168 893-901 NN denotes learning
T4169 884-892 NN denotes reversal
T4170 902-904 TO denotes to
T4171 910-911 . denotes .
T4172 911-1118 sentence denotes Mice with or without intact dopamine D2R-mediated signaling displayed similar decreases in latencies to retrieve unhidden food pellets (Fig. 1) and learned to dig for food buried in unscented sand (Fig. 2).
T4173 912-916 NNS denotes Mice
T4174 972-981 VBD denotes displayed
T4175 917-921 IN denotes with
T4176 922-924 CC denotes or
T4177 925-932 IN denotes without
T4178 933-939 JJ denotes intact
T4179 962-971 NN denotes signaling
T4180 940-948 NN denotes dopamine
T4181 949-952 NN denotes D2R
T4182 953-961 VBN denotes mediated
T4183 952-953 HYPH denotes -
T4184 982-989 JJ denotes similar
T4185 990-999 NNS denotes decreases
T4186 1000-1002 IN denotes in
T4187 1003-1012 NNS denotes latencies
T4188 1013-1015 TO denotes to
T4189 1016-1024 VB denotes retrieve
T4190 1025-1033 JJ denotes unhidden
T4191 1039-1046 NNS denotes pellets
T4192 1034-1038 NN denotes food
T4193 1047-1048 -LRB- denotes (
T4194 1048-1052 NN denotes Fig.
T4195 1053-1054 CD denotes 1
T4196 1054-1055 -RRB- denotes )
T4197 1056-1059 CC denotes and
T4198 1060-1067 VBD denotes learned
T4199 1068-1070 TO denotes to
T4200 1071-1074 VB denotes dig
T4201 1075-1078 IN denotes for
T4202 1079-1083 NN denotes food
T4203 1084-1090 VBN denotes buried
T4204 1091-1093 IN denotes in
T4205 1094-1103 JJ denotes unscented
T4206 1104-1108 NN denotes sand
T4207 1109-1110 -LRB- denotes (
T4208 1110-1114 NN denotes Fig.
T4209 1115-1116 CD denotes 2
T4210 1116-1117 -RRB- denotes )
T4211 1117-1118 . denotes .
T4212 1118-1346 sentence denotes These findings are in complete agreement with earlier studies that utilized rats and fairly selective D2R antagonists [3-8], as well as even very extensive 6-OHDA lesions [1,10,11] in associative and operant learning paradigms.
T4213 1119-1124 DT denotes These
T4214 1125-1133 NNS denotes findings
T4215 1134-1137 VBP denotes are
T4216 1138-1140 IN denotes in
T4217 1141-1149 JJ denotes complete
T4218 1150-1159 NN denotes agreement
T4219 1160-1164 IN denotes with
T4220 1165-1172 JJR denotes earlier
T4221 1173-1180 NNS denotes studies
T4222 1181-1185 WDT denotes that
T4223 1186-1194 VBD denotes utilized
T4224 1195-1199 NNS denotes rats
T4225 1200-1203 CC denotes and
T4226 1204-1210 RB denotes fairly
T4227 1211-1220 JJ denotes selective
T4228 1225-1236 NNS denotes antagonists
T4229 1221-1224 NN denotes D2R
T4230 1237-1238 -LRB- denotes [
T4231 1238-1239 CD denotes 3
T4232 1239-1240 SYM denotes -
T4233 1240-1241 CD denotes 8
T4234 1241-1242 -RRB- denotes ]
T4235 1242-1244 , denotes ,
T4236 1244-1246 RB denotes as
T4237 1252-1254 IN denotes as
T4238 1247-1251 RB denotes well
T4239 1255-1259 RB denotes even
T4240 1282-1289 NNS denotes lesions
T4241 1260-1264 RB denotes very
T4242 1265-1274 JJ denotes extensive
T4243 1275-1276 CD denotes 6
T4244 1277-1281 NN denotes OHDA
T4245 1276-1277 HYPH denotes -
T4246 1290-1291 -LRB- denotes [
T4247 1296-1298 CD denotes 11
T4248 1291-1292 CD denotes 1
T4249 1292-1293 , denotes ,
T4250 1293-1295 CD denotes 10
T4251 1295-1296 , denotes ,
T4252 1298-1299 -RRB- denotes ]
T4253 1300-1302 IN denotes in
T4254 1303-1314 JJ denotes associative
T4255 1336-1345 NNS denotes paradigms
T4256 1315-1318 CC denotes and
T4257 1319-1326 NN denotes operant
T4258 1327-1335 NN denotes learning
T4259 1345-1346 . denotes .
T4260 1346-1534 sentence denotes Our results add to a growing literature demonstrating a negligible role of dopamine, and now, specifically, D2Rs in the unconditioned or hedonic value of natural (food) reinforcers [1,2].
T4261 1347-1350 PRP$ denotes Our
T4262 1351-1358 NNS denotes results
T4263 1359-1362 VBP denotes add
T4264 1363-1365 IN denotes to
T4265 1366-1367 DT denotes a
T4266 1376-1386 NN denotes literature
T4267 1368-1375 VBG denotes growing
T4268 1387-1400 VBG denotes demonstrating
T4269 1401-1402 DT denotes a
T4270 1414-1418 NN denotes role
T4271 1403-1413 JJ denotes negligible
T4272 1419-1421 IN denotes of
T4273 1422-1430 NN denotes dopamine
T4274 1430-1432 , denotes ,
T4275 1432-1435 CC denotes and
T4276 1436-1439 RB denotes now
T4277 1455-1459 NNS denotes D2Rs
T4278 1439-1441 , denotes ,
T4279 1441-1453 RB denotes specifically
T4280 1453-1455 , denotes ,
T4281 1460-1462 IN denotes in
T4282 1463-1466 DT denotes the
T4283 1492-1497 NN denotes value
T4284 1467-1480 JJ denotes unconditioned
T4285 1481-1483 CC denotes or
T4286 1484-1491 JJ denotes hedonic
T4287 1498-1500 IN denotes of
T4288 1501-1508 JJ denotes natural
T4289 1516-1527 NNS denotes reinforcers
T4290 1509-1510 -LRB- denotes (
T4291 1510-1514 NN denotes food
T4292 1514-1515 -RRB- denotes )
T4293 1528-1529 -LRB- denotes [
T4294 1531-1532 CD denotes 2
T4295 1529-1530 CD denotes 1
T4296 1530-1531 , denotes ,
T4297 1532-1533 -RRB- denotes ]
T4298 1533-1534 . denotes .
T4299 1534-1715 sentence denotes The comparatively poor skill of D2R-/- mice during discrimination trials suggests a role for D2Rs in acquisition of appropriate S+/S- relationships in operant associative learning.
T4300 1535-1538 DT denotes The
T4301 1558-1563 NN denotes skill
T4302 1539-1552 RB denotes comparatively
T4303 1553-1557 JJ denotes poor
T4304 1608-1616 VBZ denotes suggests
T4305 1564-1566 IN denotes of
T4306 1567-1570 NN denotes D2R
T4307 1574-1578 NNS denotes mice
T4308 1570-1571 SYM denotes -
T4309 1571-1572 HYPH denotes /
T4310 1572-1573 SYM denotes -
T4311 1579-1585 IN denotes during
T4312 1586-1600 NN denotes discrimination
T4313 1601-1607 NNS denotes trials
T4314 1617-1618 DT denotes a
T4315 1619-1623 NN denotes role
T4316 1624-1627 IN denotes for
T4317 1628-1632 NNS denotes D2Rs
T4318 1633-1635 IN denotes in
T4319 1636-1647 NN denotes acquisition
T4320 1648-1650 IN denotes of
T4321 1651-1662 JJ denotes appropriate
T4322 1669-1682 NNS denotes relationships
T4323 1663-1664 NN denotes S
T4324 1664-1665 SYM denotes +
T4325 1665-1666 HYPH denotes /
T4326 1666-1667 NN denotes S
T4327 1667-1668 SYM denotes -
T4328 1683-1685 IN denotes in
T4329 1686-1693 NN denotes operant
T4330 1706-1714 NN denotes learning
T4331 1694-1705 JJ denotes associative
T4332 1714-1715 . denotes .
T4333 1715-1855 sentence denotes Several studies have demonstrated that both the acquisition [6,7] and expression [9] of associative learning are mediated by dopamine D1Rs.
T4334 1716-1723 JJ denotes Several
T4335 1724-1731 NNS denotes studies
T4336 1737-1749 VBN denotes demonstrated
T4337 1732-1736 VBP denotes have
T4338 1750-1754 IN denotes that
T4339 1829-1837 VBN denotes mediated
T4340 1755-1759 CC denotes both
T4341 1764-1775 NN denotes acquisition
T4342 1760-1763 DT denotes the
T4343 1776-1777 -LRB- denotes [
T4344 1779-1780 CD denotes 7
T4345 1777-1778 CD denotes 6
T4346 1778-1779 , denotes ,
T4347 1780-1781 -RRB- denotes ]
T4348 1782-1785 CC denotes and
T4349 1786-1796 NN denotes expression
T4350 1797-1798 -LRB- denotes [
T4351 1798-1799 CD denotes 9
T4352 1799-1800 -RRB- denotes ]
T4353 1801-1803 IN denotes of
T4354 1804-1815 JJ denotes associative
T4355 1816-1824 NN denotes learning
T4356 1825-1828 VBP denotes are
T4357 1838-1840 IN denotes by
T4358 1841-1849 NN denotes dopamine
T4359 1850-1854 NNS denotes D1Rs
T4360 1854-1855 . denotes .
T4361 1855-1985 sentence denotes Most literature reviews identify dopamine D1Rs with dopamine-mediated learning and D2Rs with motor related behaviors [e.g. [24]].
T4362 1856-1860 JJS denotes Most
T4363 1872-1879 NNS denotes reviews
T4364 1861-1871 NN denotes literature
T4365 1880-1888 VBP denotes identify
T4366 1889-1897 NN denotes dopamine
T4367 1898-1902 NNS denotes D1Rs
T4368 1903-1907 IN denotes with
T4369 1908-1916 NN denotes dopamine
T4370 1917-1925 VBN denotes mediated
T4371 1916-1917 HYPH denotes -
T4372 1926-1934 NN denotes learning
T4373 1935-1938 CC denotes and
T4374 1939-1943 NNS denotes D2Rs
T4375 1944-1948 IN denotes with
T4376 1949-1954 NN denotes motor
T4377 1955-1962 VBN denotes related
T4378 1963-1972 NNS denotes behaviors
T4379 1973-1974 -LRB- denotes [
T4380 1980-1982 CD denotes 24
T4381 1974-1978 FW denotes e.g.
T4382 1979-1980 -LRB- denotes [
T4383 1982-1983 -RRB- denotes ]
T4384 1983-1984 -RRB- denotes ]
T4385 1984-1985 . denotes .
T4386 1985-2161 sentence denotes Moreover, it has been reported that acute administration of the dopamine D2/3 antagonist, raclopride, actually improves acquisition of food-motivated associative learning [6].
T4387 1986-1994 RB denotes Moreover
T4388 2008-2016 VBN denotes reported
T4389 1994-1996 , denotes ,
T4390 1996-1998 PRP denotes it
T4391 1999-2002 VBZ denotes has
T4392 2003-2007 VBN denotes been
T4393 2017-2021 IN denotes that
T4394 2097-2105 VBZ denotes improves
T4395 2022-2027 JJ denotes acute
T4396 2028-2042 NN denotes administration
T4397 2043-2045 IN denotes of
T4398 2046-2049 DT denotes the
T4399 2064-2074 NN denotes antagonist
T4400 2050-2058 NN denotes dopamine
T4401 2059-2061 NN denotes D2
T4402 2061-2062 HYPH denotes /
T4403 2062-2063 CD denotes 3
T4404 2074-2076 , denotes ,
T4405 2076-2086 NN denotes raclopride
T4406 2086-2088 , denotes ,
T4407 2088-2096 RB denotes actually
T4408 2106-2117 NN denotes acquisition
T4409 2118-2120 IN denotes of
T4410 2121-2125 NN denotes food
T4411 2126-2135 VBN denotes motivated
T4412 2125-2126 HYPH denotes -
T4413 2148-2156 NN denotes learning
T4414 2136-2147 JJ denotes associative
T4415 2157-2158 -LRB- denotes [
T4416 2158-2159 CD denotes 6
T4417 2159-2160 -RRB- denotes ]
T4418 2160-2161 . denotes .
T4419 2161-2295 sentence denotes However, only acute administrations of antagonists were given, and learning was not measured during complete D1R or D2R blockade [6].
T4420 2162-2169 RB denotes However
T4421 2218-2223 VBN denotes given
T4422 2169-2171 , denotes ,
T4423 2171-2175 RB denotes only
T4424 2182-2197 NNS denotes administrations
T4425 2176-2181 JJ denotes acute
T4426 2198-2200 IN denotes of
T4427 2201-2212 NNS denotes antagonists
T4428 2213-2217 VBD denotes were
T4429 2223-2225 , denotes ,
T4430 2225-2228 CC denotes and
T4431 2229-2237 NN denotes learning
T4432 2246-2254 VBN denotes measured
T4433 2238-2241 VBD denotes was
T4434 2242-2245 RB denotes not
T4435 2255-2261 IN denotes during
T4436 2262-2270 JJ denotes complete
T4437 2282-2290 NN denotes blockade
T4438 2271-2274 NN denotes D1R
T4439 2275-2277 CC denotes or
T4440 2278-2281 NN denotes D2R
T4441 2291-2292 -LRB- denotes [
T4442 2292-2293 CD denotes 6
T4443 2293-2294 -RRB- denotes ]
T4444 2294-2295 . denotes .
T4445 2295-2630 sentence denotes Significantly, the reports cited above failed to address the technical limitations of the approach: i.e. that the antagonists used lack adequate subtype specificity and only partially blocked D2R-mediated signaling thus making it impossible to rigorously assess the role of D2R-mediated signaling in associative and reversal learning.
T4446 2296-2309 RB denotes Significantly
T4447 2335-2341 VBD denotes failed
T4448 2309-2311 , denotes ,
T4449 2311-2314 DT denotes the
T4450 2315-2322 NNS denotes reports
T4451 2323-2328 VBD denotes cited
T4452 2329-2334 RB denotes above
T4453 2342-2344 TO denotes to
T4454 2345-2352 VB denotes address
T4455 2353-2356 DT denotes the
T4456 2367-2378 NNS denotes limitations
T4457 2357-2366 JJ denotes technical
T4458 2379-2381 IN denotes of
T4459 2382-2385 DT denotes the
T4460 2386-2394 NN denotes approach
T4461 2394-2396 : denotes :
T4462 2396-2400 FW denotes i.e.
T4463 2427-2431 VBP denotes lack
T4464 2401-2405 IN denotes that
T4465 2406-2409 DT denotes the
T4466 2410-2421 NNS denotes antagonists
T4467 2422-2426 VBN denotes used
T4468 2432-2440 JJ denotes adequate
T4469 2449-2460 NN denotes specificity
T4470 2441-2448 NN denotes subtype
T4471 2461-2464 CC denotes and
T4472 2465-2469 RB denotes only
T4473 2470-2479 RB denotes partially
T4474 2480-2487 VBD denotes blocked
T4475 2488-2491 NN denotes D2R
T4476 2492-2500 VBN denotes mediated
T4477 2491-2492 HYPH denotes -
T4478 2501-2510 NN denotes signaling
T4479 2511-2515 RB denotes thus
T4480 2516-2522 VBG denotes making
T4481 2523-2525 PRP denotes it
T4482 2526-2536 JJ denotes impossible
T4483 2537-2539 TO denotes to
T4484 2551-2557 VB denotes assess
T4485 2540-2550 RB denotes rigorously
T4486 2558-2561 DT denotes the
T4487 2562-2566 NN denotes role
T4488 2567-2569 IN denotes of
T4489 2570-2573 NN denotes D2R
T4490 2574-2582 VBN denotes mediated
T4491 2573-2574 HYPH denotes -
T4492 2583-2592 NN denotes signaling
T4493 2593-2595 IN denotes in
T4494 2596-2607 JJ denotes associative
T4495 2621-2629 NN denotes learning
T4496 2608-2611 CC denotes and
T4497 2612-2620 NN denotes reversal
T4498 2629-2630 . denotes .
T4499 2630-2818 sentence denotes Additionally, none of these studies addressed the observation that the effects of D2R antagonists on locomotion and learning depend on whether exposure is chronic or acute [e.g. [15,16]].
T4500 2631-2643 RB denotes Additionally
T4501 2667-2676 VBD denotes addressed
T4502 2643-2645 , denotes ,
T4503 2645-2649 NN denotes none
T4504 2650-2652 IN denotes of
T4505 2653-2658 DT denotes these
T4506 2659-2666 NNS denotes studies
T4507 2677-2680 DT denotes the
T4508 2681-2692 NN denotes observation
T4509 2693-2697 IN denotes that
T4510 2756-2762 VBP denotes depend
T4511 2698-2701 DT denotes the
T4512 2702-2709 NNS denotes effects
T4513 2710-2712 IN denotes of
T4514 2713-2716 NN denotes D2R
T4515 2717-2728 NNS denotes antagonists
T4516 2729-2731 IN denotes on
T4517 2732-2742 NN denotes locomotion
T4518 2743-2746 CC denotes and
T4519 2747-2755 NN denotes learning
T4520 2763-2765 IN denotes on
T4521 2766-2773 IN denotes whether
T4522 2783-2785 VBZ denotes is
T4523 2774-2782 NN denotes exposure
T4524 2786-2793 JJ denotes chronic
T4525 2794-2796 CC denotes or
T4526 2797-2802 JJ denotes acute
T4527 2803-2804 -LRB- denotes [
T4528 2813-2815 CD denotes 16
T4529 2804-2808 FW denotes e.g.
T4530 2809-2810 -LRB- denotes [
T4531 2810-2812 CD denotes 15
T4532 2812-2813 , denotes ,
T4533 2815-2816 -RRB- denotes ]
T4534 2816-2817 -RRB- denotes ]
T4535 2817-2818 . denotes .
T4536 2818-3109 sentence denotes That D2R-mediated signaling orchestrates just motor components of learning is a conclusion that is potentially biased due to the practice of avoiding doses of drugs that induce catalepsy (and therefore measuring only partial blockade of dopamine D2Rs) and single administrations [e.g. [3]].
T4537 2819-2823 IN denotes That
T4538 2847-2859 VBZ denotes orchestrates
T4539 2824-2827 NN denotes D2R
T4540 2828-2836 VBN denotes mediated
T4541 2827-2828 HYPH denotes -
T4542 2837-2846 NN denotes signaling
T4543 2894-2896 VBZ denotes is
T4544 2860-2864 RB denotes just
T4545 2871-2881 NNS denotes components
T4547 2882-2884 IN denotes of
T4548 2885-2893 NN denotes learning
T4549 2897-2898 DT denotes a
T4550 2899-2909 NN denotes conclusion
T4551 2910-2914 WDT denotes that
T4552 2915-2917 VBZ denotes is
T4553 2918-2929 RB denotes potentially
T4554 2930-2936 VBN denotes biased
T4555 2937-2940 IN denotes due
T4556 2941-2943 IN denotes to
T4557 2944-2947 DT denotes the
T4558 2948-2956 NN denotes practice
T4559 2957-2959 IN denotes of
T4560 2960-2968 VBG denotes avoiding
T4561 2969-2974 NNS denotes doses
T4562 2975-2977 IN denotes of
T4563 2978-2983 NNS denotes drugs
T4564 2984-2988 WDT denotes that
T4565 2989-2995 VBP denotes induce
T4566 2996-3005 NN denotes catalepsy
T4567 3006-3007 -LRB- denotes (
T4568 3007-3010 CC denotes and
T4569 3011-3020 RB denotes therefore
T4570 3021-3030 VBG denotes measuring
T4571 3031-3035 RB denotes only
T4572 3044-3052 NN denotes blockade
T4573 3036-3043 JJ denotes partial
T4574 3053-3055 IN denotes of
T4575 3056-3064 NN denotes dopamine
T4576 3065-3069 NNS denotes D2Rs
T4577 3069-3070 -RRB- denotes )
T4578 3071-3074 CC denotes and
T4579 3075-3081 JJ denotes single
T4580 3082-3097 NNS denotes administrations
T4581 3098-3099 -LRB- denotes [
T4582 3105-3106 CD denotes 3
T4583 3099-3103 FW denotes e.g.
T4584 3104-3105 -LRB- denotes [
T4585 3106-3107 -RRB- denotes ]
T4586 3107-3108 -RRB- denotes ]
T4587 3108-3109 . denotes .
T4588 3109-3253 sentence denotes Quite possibly, the functional role of D2Rs in associative learning might be masked because of this concern about locomotor disruption [2,6,8].
T4589 3110-3115 RB denotes Quite
T4590 3116-3124 RB denotes possibly
T4591 3187-3193 VBN denotes masked
T4592 3124-3126 , denotes ,
T4593 3126-3129 DT denotes the
T4594 3141-3145 NN denotes role
T4595 3130-3140 JJ denotes functional
T4596 3146-3148 IN denotes of
T4597 3149-3153 NNS denotes D2Rs
T4598 3154-3156 IN denotes in
T4599 3157-3168 JJ denotes associative
T4600 3169-3177 NN denotes learning
T4601 3178-3183 MD denotes might
T4602 3184-3186 VB denotes be
T4603 3194-3201 RB denotes because
T4604 3202-3204 IN denotes of
T4605 3205-3209 DT denotes this
T4606 3210-3217 NN denotes concern
T4607 3218-3223 IN denotes about
T4608 3224-3233 NN denotes locomotor
T4609 3234-3244 NN denotes disruption
T4610 3245-3246 -LRB- denotes [
T4611 3250-3251 CD denotes 8
T4612 3246-3247 CD denotes 2
T4613 3247-3248 , denotes ,
T4614 3248-3249 CD denotes 6
T4615 3249-3250 , denotes ,
T4616 3251-3252 -RRB- denotes ]
T4617 3252-3253 . denotes .
T4618 3253-3421 sentence denotes Doses of raclopride as low as 0.5 mg/kg significantly disrupt motor behavior [25], although this peripheral dose is consistently used in learning paradigms [e.g. [6]].
T4619 3254-3259 NNS denotes Doses
T4620 3308-3315 VBP denotes disrupt
T4621 3260-3262 IN denotes of
T4622 3263-3273 NN denotes raclopride
T4623 3274-3276 RB denotes as
T4624 3284-3287 CD denotes 0.5
T4625 3277-3280 JJ denotes low
T4626 3281-3283 IN denotes as
T4627 3288-3290 NNS denotes mg
T4628 3290-3291 SYM denotes /
T4629 3291-3293 NN denotes kg
T4630 3294-3307 RB denotes significantly
T4631 3316-3321 JJ denotes motor
T4632 3322-3330 NN denotes behavior
T4633 3331-3332 -LRB- denotes [
T4634 3332-3334 CD denotes 25
T4635 3334-3335 -RRB- denotes ]
T4636 3335-3337 , denotes ,
T4637 3337-3345 IN denotes although
T4638 3383-3387 VBN denotes used
T4639 3346-3350 DT denotes this
T4640 3362-3366 NN denotes dose
T4641 3351-3361 JJ denotes peripheral
T4642 3367-3369 VBZ denotes is
T4643 3370-3382 RB denotes consistently
T4644 3388-3390 IN denotes in
T4645 3391-3399 VBG denotes learning
T4646 3400-3409 NNS denotes paradigms
T4647 3410-3411 -LRB- denotes [
T4648 3417-3418 CD denotes 6
T4649 3411-3415 FW denotes e.g.
T4650 3416-3417 -LRB- denotes [
T4651 3418-3419 -RRB- denotes ]
T4652 3419-3420 -RRB- denotes ]
T4653 3420-3421 . denotes .
T4654 3421-3535 sentence denotes One might then ask: "How then could the role of D2Rs in associative learning be dissociated from motor behavior?"
T4655 3422-3425 PRP denotes One
T4656 3437-3440 VB denotes ask
T4657 3426-3431 MD denotes might
T4658 3432-3436 RB denotes then
T4659 3440-3442 : denotes :
T4660 3442-3443 `` denotes "
T4661 3443-3446 WRB denotes How
T4662 3502-3513 VBN denotes dissociated
T4663 3447-3451 RB denotes then
T4664 3452-3457 MD denotes could
T4665 3458-3461 DT denotes the
T4666 3462-3466 NN denotes role
T4667 3467-3469 IN denotes of
T4668 3470-3474 NNS denotes D2Rs
T4669 3475-3477 IN denotes in
T4670 3478-3489 JJ denotes associative
T4671 3490-3498 NN denotes learning
T4672 3499-3501 VB denotes be
T4673 3514-3518 IN denotes from
T4674 3519-3524 JJ denotes motor
T4675 3525-3533 NN denotes behavior
T4676 3533-3534 . denotes ?
T4677 3534-3535 '' denotes "
T4678 3535-3740 sentence denotes Seminal experiments [26-28] have clearly demonstrated that repeated administration of catalepsy-inducing doses of D2R antagonists in rodents actually leads to a striking behavioral tolerance to catalepsy.
T4679 3536-3543 JJ denotes Seminal
T4680 3544-3555 NNS denotes experiments
T4681 3577-3589 VBN denotes demonstrated
T4682 3556-3557 -LRB- denotes [
T4683 3557-3559 CD denotes 26
T4684 3559-3560 SYM denotes -
T4685 3560-3562 CD denotes 28
T4686 3562-3563 -RRB- denotes ]
T4687 3564-3568 VBP denotes have
T4688 3569-3576 RB denotes clearly
T4689 3590-3594 IN denotes that
T4690 3686-3691 VBZ denotes leads
T4691 3595-3603 JJ denotes repeated
T4692 3604-3618 NN denotes administration
T4693 3619-3621 IN denotes of
T4694 3622-3631 NN denotes catalepsy
T4695 3632-3640 VBG denotes inducing
T4696 3631-3632 HYPH denotes -
T4697 3641-3646 NNS denotes doses
T4698 3647-3649 IN denotes of
T4699 3650-3653 NN denotes D2R
T4700 3654-3665 NNS denotes antagonists
T4701 3666-3668 IN denotes in
T4702 3669-3676 NNS denotes rodents
T4703 3677-3685 RB denotes actually
T4704 3692-3694 IN denotes to
T4705 3695-3696 DT denotes a
T4706 3717-3726 NN denotes tolerance
T4707 3697-3705 JJ denotes striking
T4708 3706-3716 JJ denotes behavioral
T4709 3727-3729 IN denotes to
T4710 3730-3739 NN denotes catalepsy
T4711 3739-3740 . denotes .
T4712 3740-3816 sentence denotes These doses have been shown to occupy well over 80% of available D2Rs [29].
T4713 3741-3746 DT denotes These
T4714 3747-3752 NNS denotes doses
T4715 3763-3768 VBN denotes shown
T4716 3753-3757 VBP denotes have
T4717 3758-3762 VBN denotes been
T4718 3769-3771 TO denotes to
T4719 3772-3778 VB denotes occupy
T4720 3779-3783 RB denotes well
T4721 3789-3791 CD denotes 80
T4722 3784-3788 IN denotes over
T4723 3791-3792 NN denotes %
T4724 3793-3795 IN denotes of
T4725 3796-3805 JJ denotes available
T4726 3806-3810 NNS denotes D2Rs
T4727 3811-3812 -LRB- denotes [
T4728 3812-3814 CD denotes 29
T4729 3814-3815 -RRB- denotes ]
T4730 3815-3816 . denotes .
T4731 3816-4064 sentence denotes Future experiments measuring acquisition of associative learning in rodents that received chronic administration of D2R antagonists and demonstrated behavioral tolerance to their motor disrupting effects would be a logical test of this hypothesis.
T4732 3817-3823 JJ denotes Future
T4733 3824-3835 NNS denotes experiments
T4734 4027-4029 VB denotes be
T4735 3836-3845 VBG denotes measuring
T4736 3846-3857 NN denotes acquisition
T4737 3858-3860 IN denotes of
T4738 3861-3872 JJ denotes associative
T4739 3873-3881 NN denotes learning
T4740 3882-3884 IN denotes in
T4741 3885-3892 NNS denotes rodents
T4742 3893-3897 WDT denotes that
T4743 3898-3906 VBD denotes received
T4744 3907-3914 JJ denotes chronic
T4745 3915-3929 NN denotes administration
T4746 3930-3932 IN denotes of
T4747 3933-3936 NN denotes D2R
T4748 3937-3948 NNS denotes antagonists
T4749 3949-3952 CC denotes and
T4750 3953-3965 VBD denotes demonstrated
T4751 3966-3976 JJ denotes behavioral
T4752 3977-3986 NN denotes tolerance
T4753 3987-3989 IN denotes to
T4754 3990-3995 PRP$ denotes their
T4755 4013-4020 NNS denotes effects
T4756 3996-4001 NN denotes motor
T4757 4002-4012 VBG denotes disrupting
T4758 4021-4026 MD denotes would
T4759 4030-4031 DT denotes a
T4760 4040-4044 NN denotes test
T4761 4032-4039 JJ denotes logical
T4762 4045-4047 IN denotes of
T4763 4048-4052 DT denotes this
T4764 4053-4063 NN denotes hypothesis
T4765 4063-4064 . denotes .
T4766 4064-4273 sentence denotes However, the realization that multiple dopamine receptor subtypes would be concurrently targeted with the presently commercially available antagonists, such as D2Rs, D3Rs, and D4Rs would have to be rectified.
T4767 4065-4072 RB denotes However
T4768 4252-4256 VB denotes have
T4769 4072-4074 , denotes ,
T4770 4074-4077 DT denotes the
T4771 4078-4089 NN denotes realization
T4772 4090-4094 IN denotes that
T4773 4153-4161 VBN denotes targeted
T4774 4095-4103 JJ denotes multiple
T4775 4122-4130 NNS denotes subtypes
T4776 4104-4112 NN denotes dopamine
T4777 4113-4121 NN denotes receptor
T4778 4131-4136 MD denotes would
T4779 4137-4139 VB denotes be
T4780 4140-4152 RB denotes concurrently
T4781 4162-4166 IN denotes with
T4782 4167-4170 DT denotes the
T4783 4204-4215 NNS denotes antagonists
T4784 4171-4180 RB denotes presently
T4785 4194-4203 JJ denotes available
T4786 4181-4193 RB denotes commercially
T4787 4215-4217 , denotes ,
T4788 4217-4221 JJ denotes such
T4789 4222-4224 IN denotes as
T4790 4225-4229 NNS denotes D2Rs
T4791 4229-4231 , denotes ,
T4792 4231-4235 NNS denotes D3Rs
T4793 4235-4237 , denotes ,
T4794 4237-4240 CC denotes and
T4795 4241-4245 NNS denotes D4Rs
T4796 4246-4251 MD denotes would
T4797 4257-4259 TO denotes to
T4798 4263-4272 VBN denotes rectified
T4799 4260-4262 VB denotes be
T4800 4272-4273 . denotes .
T4801 4273-4487 sentence denotes We would argue that the most parsimonious approach at this time is to utilize mice that have been genetically altered such that they are lacking one or both functional alleles of the specific receptor of interest.
T4802 4274-4276 PRP denotes We
T4803 4283-4288 VB denotes argue
T4804 4277-4282 MD denotes would
T4805 4289-4293 IN denotes that
T4806 4338-4340 VBZ denotes is
T4807 4294-4297 DT denotes the
T4808 4316-4324 NN denotes approach
T4809 4298-4302 RBS denotes most
T4810 4303-4315 JJ denotes parsimonious
T4811 4325-4327 IN denotes at
T4812 4328-4332 DT denotes this
T4813 4333-4337 NN denotes time
T4814 4341-4343 TO denotes to
T4815 4344-4351 VB denotes utilize
T4816 4352-4356 NNS denotes mice
T4817 4357-4361 WDT denotes that
T4818 4384-4391 VBN denotes altered
T4819 4362-4366 VBP denotes have
T4820 4367-4371 VBN denotes been
T4821 4372-4383 RB denotes genetically
T4822 4392-4396 JJ denotes such
T4823 4411-4418 VBG denotes lacking
T4824 4397-4401 IN denotes that
T4825 4402-4406 PRP denotes they
T4826 4407-4410 VBP denotes are
T4827 4419-4422 CD denotes one
T4828 4442-4449 NNS denotes alleles
T4829 4423-4425 CC denotes or
T4830 4426-4430 DT denotes both
T4831 4431-4441 JJ denotes functional
T4832 4450-4452 IN denotes of
T4833 4453-4456 DT denotes the
T4834 4466-4474 NN denotes receptor
T4835 4457-4465 JJ denotes specific
T4836 4475-4477 IN denotes of
T4837 4478-4486 NN denotes interest
T4838 4486-4487 . denotes .
T4839 4487-5039 sentence denotes While they do have their limitations (e.g. developmental compensation and strain effects in mouse lines not backcrossed adequately to a parental strain for a minimum of 10 generations), use of our inbred (N20 generation) animals in the present study (where no differences in locomotor behavior were detected between D2R-/- and D2R+/+ mice; Figs. 1 &2) revealed a previously unappreciated role of D2R-mediated signaling in associative learning and attention that could not be measured with the currently available, acutely administered D2R antagonists.
T4840 4488-4493 IN denotes While
T4841 4502-4506 VB denotes have
T4842 4494-4498 PRP denotes they
T4843 4499-4501 VBP denotes do
T4844 4840-4848 VBD denotes revealed
T4845 4507-4512 PRP$ denotes their
T4846 4513-4524 NNS denotes limitations
T4847 4525-4526 -LRB- denotes (
T4848 4545-4557 NN denotes compensation
T4849 4526-4530 FW denotes e.g.
T4850 4531-4544 JJ denotes developmental
T4851 4558-4561 CC denotes and
T4852 4562-4568 NN denotes strain
T4853 4569-4576 NNS denotes effects
T4854 4577-4579 IN denotes in
T4855 4580-4585 NN denotes mouse
T4856 4586-4591 NNS denotes lines
T4857 4592-4595 RB denotes not
T4858 4596-4607 VBN denotes backcrossed
T4859 4608-4618 RB denotes adequately
T4860 4619-4621 IN denotes to
T4861 4622-4623 DT denotes a
T4862 4633-4639 NN denotes strain
T4863 4624-4632 JJ denotes parental
T4864 4640-4643 IN denotes for
T4865 4644-4645 DT denotes a
T4866 4646-4653 NN denotes minimum
T4867 4654-4656 IN denotes of
T4868 4657-4659 CD denotes 10
T4869 4660-4671 NNS denotes generations
T4870 4671-4672 -RRB- denotes )
T4871 4672-4674 , denotes ,
T4872 4674-4677 NN denotes use
T4873 4678-4680 IN denotes of
T4874 4681-4684 PRP$ denotes our
T4875 4709-4716 NNS denotes animals
T4876 4685-4691 JJ denotes inbred
T4877 4692-4693 -LRB- denotes (
T4878 4697-4707 NN denotes generation
T4879 4693-4696 NN denotes N20
T4880 4707-4708 -RRB- denotes )
T4881 4717-4719 IN denotes in
T4882 4720-4723 DT denotes the
T4883 4732-4737 NN denotes study
T4884 4724-4731 JJ denotes present
T4885 4738-4739 -LRB- denotes (
T4886 4739-4744 WRB denotes where
T4887 4787-4795 VBN denotes detected
T4888 4745-4747 DT denotes no
T4889 4748-4759 NNS denotes differences
T4890 4760-4762 IN denotes in
T4891 4763-4772 NN denotes locomotor
T4892 4773-4781 NN denotes behavior
T4893 4782-4786 VBD denotes were
T4894 4796-4803 IN denotes between
T4895 4804-4807 NN denotes D2R
T4896 4822-4826 NNS denotes mice
T4897 4807-4808 SYM denotes -
T4898 4808-4809 HYPH denotes /
T4899 4809-4810 SYM denotes -
T4900 4811-4814 CC denotes and
T4901 4815-4818 NN denotes D2R
T4902 4818-4819 SYM denotes +
T4903 4819-4820 HYPH denotes /
T4904 4820-4821 SYM denotes +
T4905 4826-4827 : denotes ;
T4906 4828-4833 NNS denotes Figs.
T4907 4834-4835 CD denotes 1
T4908 4836-4837 CC denotes &
T4909 4837-4838 CD denotes 2
T4910 4838-4839 -RRB- denotes )
T4911 4849-4850 DT denotes a
T4912 4876-4880 NN denotes role
T4913 4851-4861 RB denotes previously
T4914 4862-4875 JJ denotes unappreciated
T4915 4881-4883 IN denotes of
T4916 4884-4887 NN denotes D2R
T4917 4888-4896 VBN denotes mediated
T4918 4887-4888 HYPH denotes -
T4919 4897-4906 NN denotes signaling
T4920 4907-4909 IN denotes in
T4921 4910-4921 JJ denotes associative
T4922 4922-4930 NN denotes learning
T4923 4931-4934 CC denotes and
T4924 4935-4944 NN denotes attention
T4925 4945-4949 WDT denotes that
T4926 4963-4971 VBN denotes measured
T4927 4950-4955 MD denotes could
T4928 4956-4959 RB denotes not
T4929 4960-4962 VB denotes be
T4930 4972-4976 IN denotes with
T4931 4977-4980 DT denotes the
T4932 5027-5038 NNS denotes antagonists
T4933 4981-4990 RB denotes currently
T4934 4991-5000 JJ denotes available
T4935 5000-5002 , denotes ,
T4936 5002-5009 RB denotes acutely
T4937 5010-5022 VBN denotes administered
T4938 5023-5026 NN denotes D2R
T4939 5038-5039 . denotes .
T4940 5039-5199 sentence denotes A cursory analysis of our data might suggest to some that the genetic manipulation of the drd2 locus conferred a gross olfactory impairment to the D2R-/- mice.
T4941 5040-5041 DT denotes A
T4942 5050-5058 NN denotes analysis
T4943 5042-5049 JJ denotes cursory
T4944 5077-5084 VB denotes suggest
T4945 5059-5061 IN denotes of
T4946 5062-5065 PRP$ denotes our
T4947 5066-5070 NNS denotes data
T4948 5071-5076 MD denotes might
T4949 5085-5087 IN denotes to
T4950 5088-5092 DT denotes some
T4951 5093-5097 IN denotes that
T4952 5141-5150 VBD denotes conferred
T4953 5098-5101 DT denotes the
T4954 5110-5122 NN denotes manipulation
T4955 5102-5109 JJ denotes genetic
T4956 5123-5125 IN denotes of
T4957 5126-5129 DT denotes the
T4958 5135-5140 NN denotes locus
T4959 5130-5134 NN denotes drd2
T4960 5151-5152 DT denotes a
T4961 5169-5179 NN denotes impairment
T4962 5153-5158 JJ denotes gross
T4963 5159-5168 JJ denotes olfactory
T4964 5180-5182 IN denotes to
T4965 5183-5186 DT denotes the
T4966 5194-5198 NNS denotes mice
T4967 5187-5190 NN denotes D2R
T4968 5190-5191 SYM denotes -
T4969 5191-5192 HYPH denotes /
T4970 5192-5193 SYM denotes -
T4971 5198-5199 . denotes .
T4972 5199-5376 sentence denotes Rather, we argue that this is not likely because the D2R-/- mice did learn to retrieve the food pellets from the dishes and eventually learned to accurately discriminate odors.
T4973 5200-5206 RB denotes Rather
T4974 5211-5216 VBP denotes argue
T4975 5206-5208 , denotes ,
T4976 5208-5210 PRP denotes we
T4977 5217-5221 IN denotes that
T4978 5227-5229 VBZ denotes is
T4979 5222-5226 DT denotes this
T4980 5230-5233 RB denotes not
T4981 5234-5240 JJ denotes likely
T4982 5241-5248 IN denotes because
T4983 5269-5274 VB denotes learn
T4984 5249-5252 DT denotes the
T4985 5260-5264 NNS denotes mice
T4986 5253-5256 NN denotes D2R
T4987 5256-5257 SYM denotes -
T4988 5257-5258 HYPH denotes /
T4989 5258-5259 SYM denotes -
T4990 5265-5268 VBD denotes did
T4991 5275-5277 TO denotes to
T4992 5278-5286 VB denotes retrieve
T4993 5287-5290 DT denotes the
T4994 5296-5303 NNS denotes pellets
T4995 5291-5295 NN denotes food
T4996 5304-5308 IN denotes from
T4997 5309-5312 DT denotes the
T4998 5313-5319 NNS denotes dishes
T4999 5320-5323 CC denotes and
T5000 5324-5334 RB denotes eventually
T5001 5335-5342 VBD denotes learned
T5002 5343-5345 TO denotes to
T5003 5357-5369 VB denotes discriminate
T5004 5346-5356 RB denotes accurately
T5005 5370-5375 NNS denotes odors
T5006 5375-5376 . denotes .
T5007 5376-5608 sentence denotes Recent electrophysiological data demonstrate that dopamine D2R's are located on glutamatergic terminal axons of olfactory nerves and depress excitatory input of the olfactory nerve to the mitral cells of the olfactory bulb [30,31].
T5008 5377-5383 JJ denotes Recent
T5009 5405-5409 NNS denotes data
T5010 5384-5404 JJ denotes electrophysiological
T5011 5410-5421 VBP denotes demonstrate
T5012 5422-5426 IN denotes that
T5013 5446-5453 VBN denotes located
T5014 5427-5435 NN denotes dopamine
T5015 5436-5441 NNS denotes D2R's
T5016 5442-5445 VBP denotes are
T5017 5454-5456 IN denotes on
T5018 5457-5470 JJ denotes glutamatergic
T5019 5480-5485 NNS denotes axons
T5020 5471-5479 JJ denotes terminal
T5021 5486-5488 IN denotes of
T5022 5489-5498 JJ denotes olfactory
T5023 5499-5505 NNS denotes nerves
T5024 5506-5509 CC denotes and
T5025 5510-5517 VB denotes depress
T5026 5518-5528 JJ denotes excitatory
T5027 5529-5534 NN denotes input
T5028 5535-5537 IN denotes of
T5029 5538-5541 DT denotes the
T5030 5552-5557 NN denotes nerve
T5031 5542-5551 JJ denotes olfactory
T5032 5558-5560 IN denotes to
T5033 5561-5564 DT denotes the
T5034 5572-5577 NNS denotes cells
T5035 5565-5571 JJ denotes mitral
T5036 5578-5580 IN denotes of
T5037 5581-5584 DT denotes the
T5038 5595-5599 NN denotes bulb
T5039 5585-5594 JJ denotes olfactory
T5040 5600-5601 -LRB- denotes [
T5041 5604-5606 CD denotes 31
T5042 5601-5603 CD denotes 30
T5043 5603-5604 , denotes ,
T5044 5606-5607 -RRB- denotes ]
T5045 5607-5608 . denotes .
T5046 5608-5932 sentence denotes Consequently, our data, and data from other studies, suggest that the complete lack of D2Rs in the olfactory bulb does not prevent transduction of olfactory stimuli; rather it affects the ability to habituate, or tune, olfactory nerve activity associated with repeatedly encountered concentrations of chemical stimuli [32].
T5047 5609-5621 RB denotes Consequently
T5048 5662-5669 VBP denotes suggest
T5049 5621-5623 , denotes ,
T5050 5623-5626 PRP$ denotes our
T5051 5627-5631 NNS denotes data
T5052 5631-5633 , denotes ,
T5053 5633-5636 CC denotes and
T5054 5637-5641 NNS denotes data
T5055 5642-5646 IN denotes from
T5056 5647-5652 JJ denotes other
T5057 5653-5660 NNS denotes studies
T5058 5660-5662 , denotes ,
T5059 5785-5792 VBZ denotes affects
T5060 5670-5674 IN denotes that
T5061 5732-5739 VB denotes prevent
T5062 5675-5678 DT denotes the
T5063 5688-5692 NN denotes lack
T5064 5679-5687 JJ denotes complete
T5065 5693-5695 IN denotes of
T5066 5696-5700 NNS denotes D2Rs
T5067 5701-5703 IN denotes in
T5068 5704-5707 DT denotes the
T5069 5718-5722 NN denotes bulb
T5070 5708-5717 JJ denotes olfactory
T5071 5723-5727 VBZ denotes does
T5072 5728-5731 RB denotes not
T5073 5740-5752 NN denotes transduction
T5074 5753-5755 IN denotes of
T5075 5756-5765 JJ denotes olfactory
T5076 5766-5773 NNS denotes stimuli
T5077 5773-5774 : denotes ;
T5078 5775-5781 RB denotes rather
T5079 5782-5784 PRP denotes it
T5080 5793-5796 DT denotes the
T5081 5797-5804 NN denotes ability
T5082 5805-5807 TO denotes to
T5083 5808-5817 VB denotes habituate
T5084 5817-5819 , denotes ,
T5085 5819-5821 CC denotes or
T5086 5822-5826 VB denotes tune
T5087 5826-5828 , denotes ,
T5088 5828-5837 JJ denotes olfactory
T5089 5838-5843 NN denotes nerve
T5090 5844-5852 NN denotes activity
T5091 5853-5863 VBN denotes associated
T5092 5864-5868 IN denotes with
T5093 5869-5879 RB denotes repeatedly
T5094 5880-5891 VBN denotes encountered
T5095 5892-5906 NNS denotes concentrations
T5096 5907-5909 IN denotes of
T5097 5910-5918 JJ denotes chemical
T5098 5919-5926 NNS denotes stimuli
T5099 5927-5928 -LRB- denotes [
T5100 5928-5930 CD denotes 32
T5101 5930-5931 -RRB- denotes ]
T5102 5931-5932 . denotes .
T5103 5932-6097 sentence denotes The performance of D2R-/- mice during reversal learning is deficient revealing a role for dopamine D2R-mediated signaling in tasks requiring behavioral flexibility
T5104 5934-5937 DT denotes The
T5105 5938-5949 NN denotes performance
T5106 5990-5992 VBZ denotes is
T5107 5950-5952 IN denotes of
T5108 5953-5956 NN denotes D2R
T5109 5960-5964 NNS denotes mice
T5110 5956-5957 SYM denotes -
T5111 5957-5958 HYPH denotes /
T5112 5958-5959 SYM denotes -
T5113 5965-5971 IN denotes during
T5114 5972-5980 NN denotes reversal
T5115 5981-5989 NN denotes learning
T5116 5993-6002 JJ denotes deficient
T5117 6003-6012 VBG denotes revealing
T5118 6013-6014 DT denotes a
T5119 6015-6019 NN denotes role
T5120 6020-6023 IN denotes for
T5121 6024-6032 NN denotes dopamine
T5122 6033-6036 NN denotes D2R
T5123 6037-6045 VBN denotes mediated
T5124 6036-6037 HYPH denotes -
T5125 6046-6055 NN denotes signaling
T5126 6056-6058 IN denotes in
T5127 6059-6064 NNS denotes tasks
T5128 6065-6074 VBG denotes requiring
T5129 6075-6085 JJ denotes behavioral
T5130 6086-6097 NN denotes flexibility
T5131 6097-6332 sentence denotes Perseverative behavioral patterns characterized the D2R-/- mice relative to D2R+/+ mice during reversal learning sessions (Figure 4), manifested during early reversal trials (Figure 6) and persisted across several sessions (Figure 7).
T5132 6098-6111 JJ denotes Perseverative
T5133 6123-6131 NNS denotes patterns
T5134 6112-6122 JJ denotes behavioral
T5135 6132-6145 VBD denotes characterized
T5136 6146-6149 DT denotes the
T5137 6157-6161 NNS denotes mice
T5138 6150-6153 NN denotes D2R
T5139 6153-6154 SYM denotes -
T5140 6154-6155 HYPH denotes /
T5141 6155-6156 SYM denotes -
T5142 6162-6170 JJ denotes relative
T5143 6171-6173 IN denotes to
T5144 6174-6177 NN denotes D2R
T5145 6181-6185 NNS denotes mice
T5146 6177-6178 SYM denotes +
T5147 6178-6179 HYPH denotes /
T5148 6179-6180 SYM denotes +
T5149 6186-6192 IN denotes during
T5150 6193-6201 NN denotes reversal
T5151 6211-6219 NNS denotes sessions
T5152 6202-6210 NN denotes learning
T5153 6220-6221 -LRB- denotes (
T5154 6221-6227 NN denotes Figure
T5155 6228-6229 CD denotes 4
T5156 6229-6230 -RRB- denotes )
T5157 6230-6232 , denotes ,
T5158 6232-6242 VBD denotes manifested
T5159 6243-6249 IN denotes during
T5160 6250-6255 JJ denotes early
T5161 6265-6271 NNS denotes trials
T5162 6256-6264 NN denotes reversal
T5163 6272-6273 -LRB- denotes (
T5164 6273-6279 NN denotes Figure
T5165 6280-6281 CD denotes 6
T5166 6281-6282 -RRB- denotes )
T5167 6283-6286 CC denotes and
T5168 6287-6296 VBD denotes persisted
T5169 6297-6303 IN denotes across
T5170 6304-6311 JJ denotes several
T5171 6312-6320 NNS denotes sessions
T5172 6321-6322 -LRB- denotes (
T5173 6322-6328 NN denotes Figure
T5174 6329-6330 CD denotes 7
T5175 6330-6331 -RRB- denotes )
T5176 6331-6332 . denotes .
T5177 6332-6638 sentence denotes These findings are significant because D2R-/- mice respond to food reinforcers and ultimately form and maintain odor-driven S+/S- relationships (a putative D1R-mediated behavior [6]) just as D2R+/+ mice (both groups achieved ≥ 80% discrimination accuracy, the dopamine D1Rs in our mice were not targeted).
T5178 6333-6338 DT denotes These
T5179 6339-6347 NNS denotes findings
T5180 6348-6351 VBP denotes are
T5181 6352-6363 JJ denotes significant
T5182 6364-6371 IN denotes because
T5183 6384-6391 VBP denotes respond
T5184 6372-6375 NN denotes D2R
T5185 6379-6383 NNS denotes mice
T5186 6375-6376 SYM denotes -
T5187 6376-6377 HYPH denotes /
T5188 6377-6378 SYM denotes -
T5189 6392-6394 IN denotes to
T5190 6395-6399 NN denotes food
T5191 6400-6411 NNS denotes reinforcers
T5192 6412-6415 CC denotes and
T5193 6416-6426 RB denotes ultimately
T5194 6427-6431 VBP denotes form
T5195 6432-6435 CC denotes and
T5196 6436-6444 VBP denotes maintain
T5197 6445-6449 NN denotes odor
T5198 6450-6456 VBN denotes driven
T5199 6449-6450 HYPH denotes -
T5200 6463-6476 NNS denotes relationships
T5201 6457-6458 NN denotes S
T5202 6458-6459 SYM denotes +
T5203 6459-6460 HYPH denotes /
T5204 6460-6461 NN denotes S
T5205 6461-6462 SYM denotes -
T5206 6477-6478 -LRB- denotes (
T5207 6502-6510 NN denotes behavior
T5208 6478-6479 DT denotes a
T5209 6480-6488 JJ denotes putative
T5210 6489-6492 NN denotes D1R
T5211 6493-6501 VBN denotes mediated
T5212 6492-6493 HYPH denotes -
T5213 6511-6512 -LRB- denotes [
T5214 6512-6513 CD denotes 6
T5215 6513-6514 -RRB- denotes ]
T5216 6514-6515 -RRB- denotes )
T5217 6516-6520 RB denotes just
T5218 6521-6523 IN denotes as
T5219 6524-6527 NN denotes D2R
T5220 6531-6535 NNS denotes mice
T5221 6527-6528 SYM denotes +
T5222 6528-6529 HYPH denotes /
T5223 6529-6530 SYM denotes +
T5224 6536-6537 -LRB- denotes (
T5225 6628-6636 VBN denotes targeted
T5226 6537-6541 DT denotes both
T5227 6542-6548 NNS denotes groups
T5228 6549-6557 VBD denotes achieved
T5229 6558-6559 SYM denotes ≥
T5230 6560-6562 CD denotes 80
T5231 6562-6563 NN denotes %
T5232 6579-6587 NN denotes accuracy
T5233 6564-6578 NN denotes discrimination
T5234 6587-6589 , denotes ,
T5235 6589-6592 DT denotes the
T5236 6602-6606 NNS denotes D1Rs
T5237 6593-6601 NN denotes dopamine
T5238 6607-6609 IN denotes in
T5239 6610-6613 PRP$ denotes our
T5240 6614-6618 NNS denotes mice
T5241 6619-6623 VBD denotes were
T5242 6624-6627 RB denotes not
T5243 6636-6637 -RRB- denotes )
T5244 6637-6638 . denotes .
T5245 6638-6838 sentence denotes A future extension of this study would be to test performance over a fixed number of trials and determine patterns of error rates during acquisition of the discrimination and reversal learning tasks.
T5246 6639-6640 DT denotes A
T5247 6648-6657 NN denotes extension
T5248 6641-6647 JJ denotes future
T5249 6678-6680 VB denotes be
T5250 6658-6660 IN denotes of
T5251 6661-6665 DT denotes this
T5252 6666-6671 NN denotes study
T5253 6672-6677 MD denotes would
T5254 6681-6683 TO denotes to
T5255 6684-6688 VB denotes test
T5256 6689-6700 NN denotes performance
T5257 6701-6705 IN denotes over
T5258 6706-6707 DT denotes a
T5259 6714-6720 NN denotes number
T5260 6708-6713 VBN denotes fixed
T5261 6721-6723 IN denotes of
T5262 6724-6730 NNS denotes trials
T5263 6731-6734 CC denotes and
T5264 6735-6744 VB denotes determine
T5265 6745-6753 NNS denotes patterns
T5266 6754-6756 IN denotes of
T5267 6757-6762 NN denotes error
T5268 6763-6768 NNS denotes rates
T5269 6769-6775 IN denotes during
T5270 6776-6787 NN denotes acquisition
T5271 6788-6790 IN denotes of
T5272 6791-6794 DT denotes the
T5273 6832-6837 NNS denotes tasks
T5274 6795-6809 NN denotes discrimination
T5275 6810-6813 CC denotes and
T5276 6814-6822 NN denotes reversal
T5277 6823-6831 NN denotes learning
T5278 6837-6838 . denotes .
T5279 6838-7093 sentence denotes This manipulation would control the number of errors based on trials performed to determine if the apparent difference in absolute number of errors demonstrated by the mutant mice (the putative performance deficit) is simply a reflection of extra trials.
T5280 6839-6843 DT denotes This
T5281 6844-6856 NN denotes manipulation
T5282 6863-6870 VB denotes control
T5283 6857-6862 MD denotes would
T5284 6871-6874 DT denotes the
T5285 6875-6881 NN denotes number
T5286 6882-6884 IN denotes of
T5287 6885-6891 NNS denotes errors
T5288 6892-6897 VBN denotes based
T5289 6898-6900 IN denotes on
T5290 6901-6907 NNS denotes trials
T5291 6908-6917 VBN denotes performed
T5292 6918-6920 TO denotes to
T5293 6921-6930 VB denotes determine
T5294 6931-6933 IN denotes if
T5295 7054-7056 VBZ denotes is
T5296 6934-6937 DT denotes the
T5297 6947-6957 NN denotes difference
T5298 6938-6946 JJ denotes apparent
T5299 6958-6960 IN denotes in
T5300 6961-6969 JJ denotes absolute
T5301 6970-6976 NN denotes number
T5302 6977-6979 IN denotes of
T5303 6980-6986 NNS denotes errors
T5304 6987-6999 VBN denotes demonstrated
T5305 7000-7002 IN denotes by
T5306 7003-7006 DT denotes the
T5307 7014-7018 NNS denotes mice
T5308 7007-7013 JJ denotes mutant
T5309 7019-7020 -LRB- denotes (
T5310 7045-7052 NN denotes deficit
T5311 7020-7023 DT denotes the
T5312 7024-7032 JJ denotes putative
T5313 7033-7044 NN denotes performance
T5314 7052-7053 -RRB- denotes )
T5315 7057-7063 RB denotes simply
T5316 7066-7076 NN denotes reflection
T5317 7064-7065 DT denotes a
T5318 7077-7079 IN denotes of
T5319 7080-7085 JJ denotes extra
T5320 7086-7092 NNS denotes trials
T5321 7092-7093 . denotes .
T5322 7093-7457 sentence denotes Nonetheless, the inability of D2R-/- mice to disengage from previously established S+/S- contingencies (responding to a discriminative stimulus; Fig. 4) strongly argues that mesolimbic dopamine, and in particular dopamine D2R-mediated signaling, modulates the process of alerting the subject that familiar contingencies are now associated unexpected consequences.
T5323 7094-7105 RB denotes Nonetheless
T5324 7256-7262 VBZ denotes argues
T5325 7105-7107 , denotes ,
T5326 7107-7110 DT denotes the
T5327 7111-7120 NN denotes inability
T5328 7121-7123 IN denotes of
T5329 7124-7127 NN denotes D2R
T5330 7131-7135 NNS denotes mice
T5331 7127-7128 SYM denotes -
T5332 7128-7129 HYPH denotes /
T5333 7129-7130 SYM denotes -
T5334 7136-7138 TO denotes to
T5335 7139-7148 VB denotes disengage
T5336 7149-7153 IN denotes from
T5337 7154-7164 RB denotes previously
T5338 7165-7176 VBN denotes established
T5339 7183-7196 NNS denotes contingencies
T5340 7177-7178 NN denotes S
T5341 7178-7179 SYM denotes +
T5342 7179-7180 HYPH denotes /
T5343 7180-7181 NN denotes S
T5344 7181-7182 HYPH denotes -
T5345 7197-7198 -LRB- denotes (
T5346 7239-7243 NN denotes Fig.
T5347 7198-7208 VBG denotes responding
T5348 7209-7211 IN denotes to
T5349 7212-7213 DT denotes a
T5350 7229-7237 NN denotes stimulus
T5351 7214-7228 JJ denotes discriminative
T5352 7237-7238 : denotes ;
T5353 7244-7245 CD denotes 4
T5354 7245-7246 -RRB- denotes )
T5355 7247-7255 RB denotes strongly
T5356 7263-7267 IN denotes that
T5357 7340-7349 VBZ denotes modulates
T5358 7268-7278 JJ denotes mesolimbic
T5359 7279-7287 NN denotes dopamine
T5360 7287-7289 , denotes ,
T5361 7289-7292 CC denotes and
T5362 7293-7295 IN denotes in
T5363 7329-7338 NN denotes signaling
T5364 7296-7306 JJ denotes particular
T5365 7307-7315 NN denotes dopamine
T5366 7316-7319 NN denotes D2R
T5367 7320-7328 VBN denotes mediated
T5368 7319-7320 HYPH denotes -
T5369 7338-7340 , denotes ,
T5370 7350-7353 DT denotes the
T5371 7354-7361 NN denotes process
T5372 7362-7364 IN denotes of
T5373 7365-7373 VBG denotes alerting
T5374 7374-7377 DT denotes the
T5375 7378-7385 NN denotes subject
T5376 7386-7390 IN denotes that
T5377 7422-7432 VBN denotes associated
T5378 7391-7399 JJ denotes familiar
T5379 7400-7413 NNS denotes contingencies
T5380 7414-7417 VBP denotes are
T5381 7418-7421 RB denotes now
T5382 7433-7443 JJ denotes unexpected
T5383 7444-7456 NNS denotes consequences
T5384 7456-7457 . denotes .
T5385 7457-7614 sentence denotes Schultz and colleagues have demonstrated that dopamine cells display consistent tonic firing patterns during maintenance of associative learning tasks [33].
T5386 7458-7465 NNP denotes Schultz
T5387 7486-7498 VBN denotes demonstrated
T5388 7466-7469 CC denotes and
T5389 7470-7480 NNS denotes colleagues
T5390 7481-7485 VBP denotes have
T5391 7499-7503 IN denotes that
T5392 7519-7526 VBP denotes display
T5393 7504-7512 NN denotes dopamine
T5394 7513-7518 NNS denotes cells
T5395 7527-7537 JJ denotes consistent
T5396 7551-7559 NNS denotes patterns
T5397 7538-7543 JJ denotes tonic
T5398 7544-7550 NN denotes firing
T5399 7560-7566 IN denotes during
T5400 7567-7578 NN denotes maintenance
T5401 7579-7581 IN denotes of
T5402 7582-7593 JJ denotes associative
T5403 7594-7602 NN denotes learning
T5404 7603-7608 NNS denotes tasks
T5405 7609-7610 -LRB- denotes [
T5406 7610-7612 CD denotes 33
T5407 7612-7613 -RRB- denotes ]
T5408 7613-7614 . denotes .
T5409 7614-7766 sentence denotes However, phasic burst activity of dopaminergic cells occurs when discrepancies between predicted and actual reinforcement contingencies transpire [14].
T5410 7615-7622 RB denotes However
T5411 7668-7674 VBZ denotes occurs
T5412 7622-7624 , denotes ,
T5413 7624-7630 JJ denotes phasic
T5414 7637-7645 NN denotes activity
T5415 7631-7636 NN denotes burst
T5416 7646-7648 IN denotes of
T5417 7649-7661 JJ denotes dopaminergic
T5418 7662-7667 NNS denotes cells
T5419 7675-7679 WRB denotes when
T5420 7751-7760 VBP denotes transpire
T5421 7680-7693 NNS denotes discrepancies
T5422 7694-7701 IN denotes between
T5423 7702-7711 JJ denotes predicted
T5424 7737-7750 NNS denotes contingencies
T5425 7712-7715 CC denotes and
T5426 7716-7722 JJ denotes actual
T5427 7723-7736 NN denotes reinforcement
T5428 7761-7762 -LRB- denotes [
T5429 7762-7764 CD denotes 14
T5430 7764-7765 -RRB- denotes ]
T5431 7765-7766 . denotes .
T5432 7766-7903 sentence denotes This robust increase of dopaminergic cell activation in response to unpredicted outcomes has been referred to as an "error" signal [14].
T5433 7767-7771 DT denotes This
T5434 7779-7787 NN denotes increase
T5435 7772-7778 JJ denotes robust
T5436 7865-7873 VBN denotes referred
T5437 7788-7790 IN denotes of
T5438 7791-7803 JJ denotes dopaminergic
T5439 7809-7819 NN denotes activation
T5440 7804-7808 NN denotes cell
T5441 7820-7822 IN denotes in
T5442 7823-7831 NN denotes response
T5443 7832-7834 IN denotes to
T5444 7835-7846 JJ denotes unpredicted
T5445 7847-7855 NNS denotes outcomes
T5446 7856-7859 VBZ denotes has
T5447 7860-7864 VBN denotes been
T5448 7874-7876 IN denotes to
T5449 7877-7879 IN denotes as
T5450 7880-7882 DT denotes an
T5451 7891-7897 NN denotes signal
T5452 7883-7884 `` denotes "
T5453 7884-7889 NN denotes error
T5454 7889-7890 '' denotes "
T5455 7898-7899 -LRB- denotes [
T5456 7899-7901 CD denotes 14
T5457 7901-7902 -RRB- denotes ]
T5458 7902-7903 . denotes .
T5459 7903-7978 sentence denotes To date, the molecular basis of this error signal has not been identified.
T5460 7904-7906 IN denotes To
T5461 7967-7977 VBN denotes identified
T5462 7907-7911 NN denotes date
T5463 7911-7913 , denotes ,
T5464 7913-7916 DT denotes the
T5465 7927-7932 NN denotes basis
T5466 7917-7926 JJ denotes molecular
T5467 7933-7935 IN denotes of
T5468 7936-7940 DT denotes this
T5469 7947-7953 NN denotes signal
T5470 7941-7946 NN denotes error
T5471 7954-7957 VBZ denotes has
T5472 7958-7961 RB denotes not
T5473 7962-7966 VBN denotes been
T5474 7977-7978 . denotes .
T5475 7978-8165 sentence denotes The inability of the D2R-/- mice to desist responding to a previously reinforced stimulus suggests that the dopamine D2R might in fact be the focal point of this error-signaling cascade.
T5476 7979-7982 DT denotes The
T5477 7983-7992 NN denotes inability
T5478 8069-8077 VBZ denotes suggests
T5479 7993-7995 IN denotes of
T5480 7996-7999 DT denotes the
T5481 8007-8011 NNS denotes mice
T5482 8000-8003 NN denotes D2R
T5483 8003-8004 SYM denotes -
T5484 8004-8005 HYPH denotes /
T5485 8005-8006 SYM denotes -
T5486 8012-8014 TO denotes to
T5487 8015-8021 VB denotes desist
T5488 8022-8032 VBG denotes responding
T5489 8033-8035 IN denotes to
T5490 8036-8037 DT denotes a
T5491 8060-8068 NN denotes stimulus
T5492 8038-8048 RB denotes previously
T5493 8049-8059 VBN denotes reinforced
T5494 8078-8082 IN denotes that
T5495 8114-8116 VB denotes be
T5496 8083-8086 DT denotes the
T5497 8096-8099 NN denotes D2R
T5498 8087-8095 NN denotes dopamine
T5499 8100-8105 MD denotes might
T5500 8106-8108 IN denotes in
T5501 8109-8113 NN denotes fact
T5502 8117-8120 DT denotes the
T5503 8127-8132 NN denotes point
T5504 8121-8126 JJ denotes focal
T5505 8133-8135 IN denotes of
T5506 8136-8140 DT denotes this
T5507 8157-8164 NN denotes cascade
T5508 8141-8146 NN denotes error
T5509 8147-8156 VBG denotes signaling
T5510 8146-8147 HYPH denotes -
T5511 8164-8165 . denotes .
T5512 8165-8308 sentence denotes Electrophysiological data further support the hypothesis that signaling mediated by dopamine D2Rs tunes D1R-mediated mesocorticolimbic output.
T5513 8166-8186 JJ denotes Electrophysiological
T5514 8187-8191 NNS denotes data
T5515 8200-8207 VBP denotes support
T5516 8192-8199 RB denotes further
T5517 8208-8211 DT denotes the
T5518 8212-8222 NN denotes hypothesis
T5519 8223-8227 IN denotes that
T5520 8264-8269 VBZ denotes tunes
T5521 8228-8237 NN denotes signaling
T5522 8238-8246 VBN denotes mediated
T5523 8247-8249 IN denotes by
T5524 8250-8258 NN denotes dopamine
T5525 8259-8263 NNS denotes D2Rs
T5526 8270-8273 NN denotes D1R
T5527 8274-8282 VBN denotes mediated
T5528 8273-8274 HYPH denotes -
T5529 8301-8307 NN denotes output
T5530 8283-8300 JJ denotes mesocorticolimbic
T5531 8307-8308 . denotes .
T5532 8308-8507 sentence denotes Calabresi et al. [34] demonstrated that tetanic stimulation of dorsal striatum slices prepared from D2R-/- mice is associated with enhanced EPSP and as a result increased striatal synaptic efficacy.
T5533 8309-8318 NNP denotes Calabresi
T5534 8331-8343 VBD denotes demonstrated
T5535 8319-8321 FW denotes et
T5536 8322-8325 FW denotes al.
T5537 8326-8327 -LRB- denotes [
T5538 8327-8329 CD denotes 34
T5539 8329-8330 -RRB- denotes ]
T5540 8344-8348 IN denotes that
T5541 8424-8434 VBN denotes associated
T5542 8349-8356 JJ denotes tetanic
T5543 8357-8368 NN denotes stimulation
T5544 8369-8371 IN denotes of
T5545 8372-8378 JJ denotes dorsal
T5546 8388-8394 NNS denotes slices
T5547 8379-8387 NN denotes striatum
T5548 8395-8403 VBN denotes prepared
T5549 8404-8408 IN denotes from
T5550 8409-8412 NN denotes D2R
T5551 8416-8420 NNS denotes mice
T5552 8412-8413 SYM denotes -
T5553 8413-8414 HYPH denotes /
T5554 8414-8415 SYM denotes -
T5555 8421-8423 VBZ denotes is
T5556 8435-8439 IN denotes with
T5557 8440-8448 VBN denotes enhanced
T5558 8449-8453 NN denotes EPSP
T5559 8454-8457 CC denotes and
T5560 8458-8460 IN denotes as
T5561 8498-8506 NN denotes efficacy
T5562 8461-8462 DT denotes a
T5563 8463-8469 NN denotes result
T5564 8470-8479 VBN denotes increased
T5565 8480-8488 JJ denotes striatal
T5566 8489-8497 JJ denotes synaptic
T5567 8506-8507 . denotes .
T5568 8507-8687 sentence denotes In contrast, stimulation of dorsal striatum slices from wild-type mice resulted in IPSP activity, long-term depression, and decreased neuronal activity of striatal efferents [34].
T5569 8508-8510 IN denotes In
T5570 8579-8587 VBD denotes resulted
T5571 8511-8519 NN denotes contrast
T5572 8519-8521 , denotes ,
T5573 8521-8532 NN denotes stimulation
T5574 8533-8535 IN denotes of
T5575 8536-8542 JJ denotes dorsal
T5576 8552-8558 NNS denotes slices
T5577 8543-8551 NN denotes striatum
T5578 8559-8563 IN denotes from
T5579 8564-8568 JJ denotes wild
T5580 8569-8573 NN denotes type
T5581 8568-8569 HYPH denotes -
T5582 8574-8578 NNS denotes mice
T5583 8588-8590 IN denotes in
T5584 8591-8595 NN denotes IPSP
T5585 8596-8604 NN denotes activity
T5586 8604-8606 , denotes ,
T5587 8606-8610 JJ denotes long
T5588 8611-8615 NN denotes term
T5589 8610-8611 HYPH denotes -
T5590 8616-8626 NN denotes depression
T5591 8626-8628 , denotes ,
T5592 8628-8631 CC denotes and
T5593 8632-8641 VBN denotes decreased
T5594 8651-8659 NN denotes activity
T5595 8642-8650 JJ denotes neuronal
T5596 8660-8662 IN denotes of
T5597 8663-8671 JJ denotes striatal
T5598 8672-8681 NNS denotes efferents
T5599 8682-8683 -LRB- denotes [
T5600 8683-8685 CD denotes 34
T5601 8685-8686 -RRB- denotes ]
T5602 8686-8687 . denotes .
T5603 8687-8861 sentence denotes Carlsson and colleagues [35] have speculated that dopamine D2R stimulation in the striatum serves to "brake" or diminish excitatory corticostriatal signaling and plasticity.
T5604 8688-8696 NNP denotes Carlsson
T5605 8722-8732 VBN denotes speculated
T5606 8697-8700 CC denotes and
T5607 8701-8711 NNS denotes colleagues
T5608 8712-8713 -LRB- denotes [
T5609 8713-8715 CD denotes 35
T5610 8715-8716 -RRB- denotes ]
T5611 8717-8721 VBP denotes have
T5612 8733-8737 IN denotes that
T5613 8779-8785 VBZ denotes serves
T5614 8738-8746 NN denotes dopamine
T5615 8747-8750 NN denotes D2R
T5616 8751-8762 NN denotes stimulation
T5617 8763-8765 IN denotes in
T5618 8766-8769 DT denotes the
T5619 8770-8778 NN denotes striatum
T5620 8786-8788 TO denotes to
T5621 8790-8795 VB denotes brake
T5622 8789-8790 `` denotes "
T5623 8795-8796 '' denotes "
T5624 8797-8799 CC denotes or
T5625 8800-8808 VB denotes diminish
T5626 8809-8819 JJ denotes excitatory
T5627 8836-8845 NN denotes signaling
T5628 8820-8835 JJ denotes corticostriatal
T5629 8846-8849 CC denotes and
T5630 8850-8860 NN denotes plasticity
T5631 8860-8861 . denotes .
T5632 8861-9121 sentence denotes Indeed, perseverative behavior is associated with over activity of the dorsal striatum in rodents [36] and over activity of the caudate in patients with ADHD [37] and a strong inverse correlation of D2R binding with compulsive behavior has been reported [22].
T5633 8862-8868 RB denotes Indeed
T5634 8896-8906 VBN denotes associated
T5635 8868-8870 , denotes ,
T5636 8870-8883 JJ denotes perseverative
T5637 8884-8892 NN denotes behavior
T5638 8893-8895 VBZ denotes is
T5639 8907-8911 IN denotes with
T5640 8912-8916 JJ denotes over
T5641 8917-8925 NN denotes activity
T5642 8926-8928 IN denotes of
T5643 8929-8932 DT denotes the
T5644 8940-8948 NN denotes striatum
T5645 8933-8939 JJ denotes dorsal
T5646 8949-8951 IN denotes in
T5647 8952-8959 NNS denotes rodents
T5648 8960-8961 -LRB- denotes [
T5649 8961-8963 CD denotes 36
T5650 8963-8964 -RRB- denotes ]
T5651 8965-8968 CC denotes and
T5652 8969-8973 JJ denotes over
T5653 8974-8982 NN denotes activity
T5654 8983-8985 IN denotes of
T5655 8986-8989 DT denotes the
T5656 8990-8997 NN denotes caudate
T5657 8998-9000 IN denotes in
T5658 9001-9009 NNS denotes patients
T5659 9010-9014 IN denotes with
T5660 9015-9019 NN denotes ADHD
T5661 9020-9021 -LRB- denotes [
T5662 9021-9023 CD denotes 37
T5663 9023-9024 -RRB- denotes ]
T5664 9025-9028 CC denotes and
T5665 9029-9030 DT denotes a
T5666 9046-9057 NN denotes correlation
T5667 9031-9037 JJ denotes strong
T5668 9038-9045 JJ denotes inverse
T5669 9107-9115 VBN denotes reported
T5670 9058-9060 IN denotes of
T5671 9061-9064 NN denotes D2R
T5672 9065-9072 NN denotes binding
T5673 9073-9077 IN denotes with
T5674 9078-9088 JJ denotes compulsive
T5675 9089-9097 NN denotes behavior
T5676 9098-9101 VBZ denotes has
T5677 9102-9106 VBN denotes been
T5678 9116-9117 -LRB- denotes [
T5679 9117-9119 CD denotes 22
T5680 9119-9120 -RRB- denotes ]
T5681 9120-9121 . denotes .
T5682 9121-9308 sentence denotes Importantly, our data indicate that the poor performances displayed by the D2R-/- mice are manifestations of reversal learning deficits and not gross motivational or sensory impairments.
T5683 9122-9133 RB denotes Importantly
T5684 9144-9152 VBP denotes indicate
T5685 9133-9135 , denotes ,
T5686 9135-9138 PRP$ denotes our
T5687 9139-9143 NNS denotes data
T5688 9153-9157 IN denotes that
T5689 9209-9212 VBP denotes are
T5690 9158-9161 DT denotes the
T5691 9167-9179 NNS denotes performances
T5692 9162-9166 JJ denotes poor
T5693 9180-9189 VBN denotes displayed
T5694 9190-9192 IN denotes by
T5695 9193-9196 DT denotes the
T5696 9204-9208 NNS denotes mice
T5697 9197-9200 NN denotes D2R
T5698 9200-9201 SYM denotes -
T5699 9201-9202 HYPH denotes /
T5700 9202-9203 SYM denotes -
T5701 9213-9227 NNS denotes manifestations
T5702 9228-9230 IN denotes of
T5703 9231-9239 NN denotes reversal
T5704 9240-9248 NN denotes learning
T5705 9249-9257 NNS denotes deficits
T5706 9258-9261 CC denotes and
T5707 9262-9265 RB denotes not
T5708 9266-9271 JJ denotes gross
T5709 9296-9307 NNS denotes impairments
T4546 2865-2870 JJ denotes motor
T5710 9272-9284 JJ denotes motivational
T5711 9285-9287 CC denotes or
T5712 9288-9295 JJ denotes sensory
T5713 9307-9308 . denotes .
T5714 9308-9487 sentence denotes We therefore argue that D2Rs participate in signaling or alerting the organism of learning contingency changes during reversal learning and sculpt ongoing goal-directed behavior.
T5715 9309-9311 PRP denotes We
T5716 9322-9327 VBP denotes argue
T5717 9312-9321 RB denotes therefore
T5718 9328-9332 IN denotes that
T5719 9338-9349 VBP denotes participate
T5720 9333-9337 NNS denotes D2Rs
T5721 9350-9352 IN denotes in
T5722 9353-9362 VBG denotes signaling
T5723 9363-9365 CC denotes or
T5724 9366-9374 VBG denotes alerting
T5725 9375-9378 DT denotes the
T5726 9379-9387 NN denotes organism
T5727 9388-9390 IN denotes of
T5728 9391-9399 NN denotes learning
T5729 9400-9411 NN denotes contingency
T5730 9412-9419 NNS denotes changes
T5731 9420-9426 IN denotes during
T5732 9427-9435 NN denotes reversal
T5733 9436-9444 NN denotes learning
T5734 9445-9448 CC denotes and
T5735 9449-9455 VBP denotes sculpt
T5736 9456-9463 JJ denotes ongoing
T5737 9478-9486 NN denotes behavior
T5738 9464-9468 NN denotes goal
T5739 9469-9477 VBN denotes directed
T5740 9468-9469 HYPH denotes -
T5741 9486-9487 . denotes .
R2145 T4023 T4024 prep In,sought
R2146 T4025 T4026 det this,study
R2147 T4026 T4023 pobj study,In
R2148 T4027 T4024 punct ", ",sought
R2149 T4028 T4024 nsubj we,sought
R2150 T4029 T4030 aux to,determine
R2151 T4030 T4024 xcomp determine,sought
R2152 T4031 T4032 det the,contribution
R2153 T4032 T4030 dobj contribution,determine
R2154 T4033 T4032 prep of,contribution
R2155 T4034 T4035 compound dopamine,D2
R2156 T4035 T4036 compound D2,receptor
R2157 T4036 T4037 npadvmod receptor,mediated
R2158 T4037 T4039 amod mediated,signaling
R2159 T4038 T4037 punct -,mediated
R2160 T4039 T4033 pobj signaling,of
R2161 T4040 T4032 prep to,contribution
R2162 T4041 T4042 det the,stages
R2163 T4042 T4040 pobj stages,to
R2164 T4043 T4042 amod various,stages
R2165 T4044 T4042 prep of,stages
R2166 T4045 T4046 amod associative,learning
R2167 T4046 T4044 pobj learning,of
R2168 T4047 T4045 cc and,associative
R2169 T4048 T4045 conj reversal,associative
R2170 T4049 T4024 punct .,sought
R2171 T4051 T4052 nmod D2R,mice
R2172 T4052 T4056 nsubj mice,demonstrated
R2173 T4053 T4051 punct -,D2R
R2174 T4054 T4051 punct /,D2R
R2175 T4055 T4051 punct -,D2R
R2176 T4057 T4058 mark that,were
R2177 T4058 T4056 ccomp were,demonstrated
R2178 T4059 T4058 nsubj they,were
R2179 T4060 T4058 acomp capable,were
R2180 T4061 T4060 prep of,capable
R2181 T4062 T4061 pcomp learning,of
R2182 T4063 T4064 aux to,locate
R2183 T4064 T4062 xcomp locate,learning
R2184 T4065 T4064 cc and,locate
R2185 T4066 T4064 conj consume,locate
R2186 T4067 T4068 compound food,pellets
R2187 T4068 T4066 dobj pellets,consume
R2188 T4069 T4056 punct ", ",demonstrated
R2189 T4070 T4056 advcl indicating,demonstrated
R2190 T4071 T4072 mark that,disrupted
R2191 T4072 T4070 ccomp disrupted,indicating
R2192 T4073 T4074 poss their,behavior
R2193 T4074 T4072 nsubjpass behavior,disrupted
R2194 T4075 T4074 compound locomotor,behavior
R2195 T4076 T4072 auxpass was,disrupted
R2196 T4077 T4072 neg not,disrupted
R2197 T4078 T4072 advmod detectably,disrupted
R2198 T4079 T4072 cc and,disrupted
R2199 T4080 T4081 poss their,motivation
R2200 T4081 T4083 nsubj motivation,was
R2201 T4082 T4081 amod primary,motivation
R2202 T4083 T4072 conj was,disrupted
R2203 T4084 T4085 aux to,obtain
R2204 T4085 T4081 acl obtain,motivation
R2205 T4086 T4087 det a,reinforcer
R2206 T4087 T4085 dobj reinforcer,obtain
R2207 T4088 T4087 amod natural,reinforcer
R2208 T4089 T4087 punct (,reinforcer
R2209 T4090 T4091 compound food,pellet
R2210 T4091 T4087 appos pellet,reinforcer
R2211 T4092 T4087 punct ),reinforcer
R2212 T4093 T4083 acomp undisturbed,was
R2213 T4094 T4056 punct .,demonstrated
R2214 T4096 T4097 advmod Rather,argues
R2215 T4098 T4097 punct ", ",argues
R2216 T4099 T4100 det the,ability
R2217 T4100 T4097 nsubj ability,argues
R2218 T4101 T4100 amod impaired,ability
R2219 T4102 T4100 prep of,ability
R2220 T4103 T4104 nmod D2R,mice
R2221 T4104 T4102 pobj mice,of
R2222 T4105 T4103 punct -,D2R
R2223 T4106 T4103 punct /,D2R
R2224 T4107 T4103 punct -,D2R
R2225 T4108 T4109 aux to,assign
R2226 T4109 T4100 acl assign,ability
R2227 T4110 T4111 amod appropriate,relationships
R2228 T4111 T4109 dobj relationships,assign
R2229 T4112 T4113 amod discriminative,stimulus
R2230 T4113 T4111 compound stimulus,relationships
R2231 T4114 T4109 prep in,assign
R2232 T4115 T4116 det an,task
R2233 T4116 T4114 pobj task,in
R2234 T4117 T4116 compound operant,task
R2235 T4118 T4116 compound discrimination,task
R2236 T4119 T4120 mark that,contributes
R2237 T4120 T4097 ccomp contributes,argues
R2238 T4121 T4122 npadvmod D2R,mediated
R2239 T4122 T4124 amod mediated,signaling
R2240 T4123 T4122 punct -,mediated
R2241 T4124 T4120 nsubj signaling,contributes
R2242 T4125 T4120 prep to,contributes
R2243 T4126 T4127 det the,processes
R2244 T4127 T4125 pobj processes,to
R2245 T4128 T4127 amod neuronal,processes
R2246 T4129 T4127 acl involved,processes
R2247 T4130 T4129 prep in,involved
R2248 T4131 T4130 pcomp attaching,in
R2249 T4132 T4131 dobj salience,attaching
R2250 T4133 T4131 prep to,attaching
R2251 T4134 T4135 amod environmental,stimuli
R2252 T4135 T4133 pobj stimuli,to
R2253 T4136 T4097 punct .,argues
R2254 T4138 T4139 det The,capacity
R2255 T4139 T4141 nsubj capacity,argues
R2256 T4140 T4139 amod deficient,capacity
R2257 T4142 T4139 prep of,capacity
R2258 T4143 T4144 nmod D2R,mice
R2259 T4144 T4142 pobj mice,of
R2260 T4145 T4143 punct -,D2R
R2261 T4146 T4143 punct /,D2R
R2262 T4147 T4143 punct -,D2R
R2263 T4148 T4149 aux to,disengage
R2264 T4149 T4139 acl disengage,capacity
R2265 T4150 T4151 amod inappropriate,strategies
R2266 T4151 T4149 dobj strategies,disengage
R2267 T4152 T4151 compound decision,strategies
R2268 T4153 T4141 advmod strongly,argues
R2269 T4154 T4155 mark that,is
R2270 T4155 T4141 ccomp is,argues
R2271 T4156 T4157 amod mesolimbic,signaling
R2272 T4157 T4155 nsubj signaling,is
R2273 T4158 T4157 compound dopamine,signaling
R2274 T4159 T4157 punct ", ",signaling
R2275 T4160 T4157 acl mediated,signaling
R2276 T4161 T4160 agent by,mediated
R2277 T4162 T4163 compound dopamine,D2Rs
R2278 T4163 T4161 pobj D2Rs,by
R2279 T4164 T4155 acomp essential,is
R2280 T4165 T4166 mark for,occur
R2281 T4166 T4155 advcl occur,is
R2282 T4167 T4168 amod efficient,learning
R2283 T4168 T4166 nsubj learning,occur
R2284 T4169 T4168 compound reversal,learning
R2285 T4170 T4166 aux to,occur
R2286 T4171 T4141 punct .,argues
R2287 T4173 T4174 nsubj Mice,displayed
R2288 T4175 T4173 prep with,Mice
R2289 T4176 T4175 cc or,with
R2290 T4177 T4175 conj without,with
R2291 T4178 T4179 amod intact,signaling
R2292 T4179 T4177 pobj signaling,without
R2293 T4180 T4181 compound dopamine,D2R
R2294 T4181 T4182 npadvmod D2R,mediated
R2295 T4182 T4179 amod mediated,signaling
R2296 T4183 T4182 punct -,mediated
R2297 T4184 T4185 amod similar,decreases
R2298 T4185 T4174 dobj decreases,displayed
R2299 T4186 T4185 prep in,decreases
R2300 T4187 T4186 pobj latencies,in
R2301 T4188 T4189 aux to,retrieve
R2302 T4189 T4187 acl retrieve,latencies
R2303 T4190 T4191 amod unhidden,pellets
R2304 T4191 T4189 dobj pellets,retrieve
R2305 T4192 T4191 compound food,pellets
R2306 T4193 T4194 punct (,Fig.
R2307 T4194 T4174 parataxis Fig.,displayed
R2308 T4195 T4194 nummod 1,Fig.
R2309 T4196 T4194 punct ),Fig.
R2310 T4197 T4174 cc and,displayed
R2311 T4198 T4174 conj learned,displayed
R2312 T4199 T4200 aux to,dig
R2313 T4200 T4198 xcomp dig,learned
R2314 T4201 T4200 prep for,dig
R2315 T4202 T4201 pobj food,for
R2316 T4203 T4202 acl buried,food
R2317 T4204 T4203 prep in,buried
R2318 T4205 T4206 amod unscented,sand
R2319 T4206 T4204 pobj sand,in
R2320 T4207 T4208 punct (,Fig.
R2321 T4208 T4200 parataxis Fig.,dig
R2322 T4209 T4208 nummod 2,Fig.
R2323 T4210 T4208 punct ),Fig.
R2324 T4211 T4174 punct .,displayed
R2325 T4213 T4214 det These,findings
R2326 T4214 T4215 nsubj findings,are
R2327 T4216 T4215 prep in,are
R2328 T4217 T4218 amod complete,agreement
R2329 T4218 T4216 pobj agreement,in
R2330 T4219 T4218 prep with,agreement
R2331 T4220 T4221 amod earlier,studies
R2332 T4221 T4219 pobj studies,with
R2333 T4222 T4223 dep that,utilized
R2334 T4223 T4221 relcl utilized,studies
R2335 T4224 T4223 dobj rats,utilized
R2336 T4225 T4224 cc and,rats
R2337 T4226 T4227 advmod fairly,selective
R2338 T4227 T4228 amod selective,antagonists
R2339 T4228 T4224 conj antagonists,rats
R2340 T4229 T4228 compound D2R,antagonists
R2341 T4230 T4231 punct [,3
R2342 T4231 T4228 parataxis 3,antagonists
R2343 T4232 T4233 punct -,8
R2344 T4233 T4231 prep 8,3
R2345 T4234 T4231 punct ],3
R2346 T4235 T4224 punct ", ",rats
R2347 T4236 T4237 advmod as,as
R2348 T4237 T4224 cc as,rats
R2349 T4238 T4237 advmod well,as
R2350 T4239 T4240 advmod even,lesions
R2351 T4240 T4224 conj lesions,rats
R2352 T4241 T4242 advmod very,extensive
R2353 T4242 T4240 amod extensive,lesions
R2354 T4243 T4244 nummod 6,OHDA
R2355 T4244 T4240 compound OHDA,lesions
R2356 T4245 T4244 punct -,OHDA
R2357 T4246 T4247 punct [,11
R2358 T4247 T4240 parataxis 11,lesions
R2359 T4248 T4247 nummod 1,11
R2360 T4249 T4247 punct ",",11
R2361 T4250 T4247 nummod 10,11
R2362 T4251 T4247 punct ",",11
R2363 T4252 T4247 punct ],11
R2364 T4253 T4223 prep in,utilized
R2365 T4254 T4255 amod associative,paradigms
R2366 T4255 T4253 pobj paradigms,in
R2367 T4256 T4254 cc and,associative
R2368 T4257 T4254 conj operant,associative
R2369 T4258 T4255 compound learning,paradigms
R2370 T4259 T4215 punct .,are
R2371 T4261 T4262 poss Our,results
R2372 T4262 T4263 nsubj results,add
R2373 T4264 T4263 prep to,add
R2374 T4265 T4266 det a,literature
R2375 T4266 T4264 pobj literature,to
R2376 T4267 T4266 amod growing,literature
R2377 T4268 T4266 acl demonstrating,literature
R2378 T4269 T4270 det a,role
R2379 T4270 T4268 dobj role,demonstrating
R2380 T4271 T4270 amod negligible,role
R2381 T4272 T4270 prep of,role
R2382 T4273 T4272 pobj dopamine,of
R2383 T4274 T4273 punct ", ",dopamine
R2384 T4275 T4273 cc and,dopamine
R2385 T4276 T4277 advmod now,D2Rs
R2386 T4277 T4273 conj D2Rs,dopamine
R2387 T4278 T4277 punct ", ",D2Rs
R2388 T4279 T4277 advmod specifically,D2Rs
R2389 T4280 T4277 punct ", ",D2Rs
R2390 T4281 T4270 prep in,role
R2391 T4282 T4283 det the,value
R2392 T4283 T4281 pobj value,in
R2393 T4284 T4283 amod unconditioned,value
R2394 T4285 T4284 cc or,unconditioned
R2395 T4286 T4284 conj hedonic,unconditioned
R2396 T4287 T4283 prep of,value
R2397 T4288 T4289 amod natural,reinforcers
R2398 T4289 T4287 pobj reinforcers,of
R2399 T4290 T4289 punct (,reinforcers
R2400 T4291 T4289 nmod food,reinforcers
R2401 T4292 T4289 punct ),reinforcers
R2402 T4293 T4294 punct [,2
R2403 T4294 T4289 parataxis 2,reinforcers
R2404 T4295 T4294 nummod 1,2
R2405 T4296 T4294 punct ",",2
R2406 T4297 T4294 punct ],2
R2407 T4298 T4263 punct .,add
R2408 T4300 T4301 det The,skill
R2409 T4301 T4304 nsubj skill,suggests
R2410 T4302 T4303 advmod comparatively,poor
R2411 T4303 T4301 amod poor,skill
R2412 T4305 T4301 prep of,skill
R2413 T4306 T4307 nmod D2R,mice
R2414 T4307 T4305 pobj mice,of
R2415 T4308 T4306 punct -,D2R
R2416 T4309 T4306 punct /,D2R
R2417 T4310 T4306 punct -,D2R
R2418 T4311 T4301 prep during,skill
R2419 T4312 T4313 compound discrimination,trials
R2420 T4313 T4311 pobj trials,during
R2421 T4314 T4315 det a,role
R2422 T4315 T4304 dobj role,suggests
R2423 T4316 T4315 prep for,role
R2424 T4317 T4316 pobj D2Rs,for
R2425 T4318 T4304 prep in,suggests
R2426 T4319 T4318 pobj acquisition,in
R2427 T4320 T4319 prep of,acquisition
R2428 T4321 T4322 amod appropriate,relationships
R2429 T4322 T4320 pobj relationships,of
R2430 T4323 T4322 nmod S,relationships
R2431 T4324 T4323 punct +,S
R2432 T4325 T4323 punct /,S
R2433 T4326 T4323 appos S,S
R2434 T4327 T4326 punct -,S
R2435 T4328 T4319 prep in,acquisition
R2436 T4329 T4330 nmod operant,learning
R2437 T4330 T4328 pobj learning,in
R2438 T4331 T4330 amod associative,learning
R2439 T4332 T4304 punct .,suggests
R2440 T4334 T4335 amod Several,studies
R2441 T4335 T4336 nsubj studies,demonstrated
R2442 T4337 T4336 aux have,demonstrated
R2443 T4338 T4339 mark that,mediated
R2444 T4339 T4336 ccomp mediated,demonstrated
R2445 T4340 T4341 preconj both,acquisition
R2446 T4341 T4339 nsubjpass acquisition,mediated
R2447 T4342 T4341 det the,acquisition
R2448 T4343 T4344 punct [,7
R2449 T4344 T4341 parataxis 7,acquisition
R2450 T4345 T4344 nummod 6,7
R2451 T4346 T4344 punct ",",7
R2452 T4347 T4344 punct ],7
R2453 T4348 T4341 cc and,acquisition
R2454 T4349 T4341 conj expression,acquisition
R2455 T4350 T4351 punct [,9
R2456 T4351 T4349 parataxis 9,expression
R2457 T4352 T4351 punct ],9
R2458 T4353 T4341 prep of,acquisition
R2459 T4354 T4355 amod associative,learning
R2460 T4355 T4353 pobj learning,of
R2461 T4356 T4339 auxpass are,mediated
R2462 T4357 T4339 agent by,mediated
R2463 T4358 T4359 compound dopamine,D1Rs
R2464 T4359 T4357 pobj D1Rs,by
R2465 T4360 T4336 punct .,demonstrated
R2466 T4362 T4363 amod Most,reviews
R2467 T4363 T4365 nsubj reviews,identify
R2468 T4364 T4363 compound literature,reviews
R2469 T4366 T4367 compound dopamine,D1Rs
R2470 T4367 T4365 dobj D1Rs,identify
R2471 T4368 T4365 prep with,identify
R2472 T4369 T4370 npadvmod dopamine,mediated
R2473 T4370 T4372 amod mediated,learning
R2474 T4371 T4370 punct -,mediated
R2475 T4372 T4368 pobj learning,with
R2476 T4373 T4365 cc and,identify
R2477 T4374 T4365 conj D2Rs,identify
R2478 T4375 T4374 prep with,D2Rs
R2479 T4376 T4377 npadvmod motor,related
R2480 T4377 T4378 amod related,behaviors
R2481 T4378 T4375 pobj behaviors,with
R2482 T4379 T4380 punct [,24
R2483 T4380 T4378 parataxis 24,behaviors
R2484 T4381 T4380 advmod e.g.,24
R2485 T4382 T4380 punct [,24
R2486 T4383 T4380 punct ],24
R2487 T4384 T4380 punct ],24
R2488 T4385 T4365 punct .,identify
R2489 T4387 T4388 advmod Moreover,reported
R2490 T4389 T4388 punct ", ",reported
R2491 T4390 T4388 nsubjpass it,reported
R2492 T4391 T4388 aux has,reported
R2493 T4392 T4388 auxpass been,reported
R2494 T4393 T4394 mark that,improves
R2495 T4394 T4388 ccomp improves,reported
R2496 T4395 T4396 amod acute,administration
R2497 T4396 T4394 nsubj administration,improves
R2498 T4397 T4396 prep of,administration
R2499 T4398 T4399 det the,antagonist
R2500 T4399 T4397 pobj antagonist,of
R2501 T4400 T4401 nmod dopamine,D2
R2502 T4401 T4399 nmod D2,antagonist
R2503 T4402 T4401 punct /,D2
R2504 T4403 T4401 nummod 3,D2
R2505 T4404 T4399 punct ", ",antagonist
R2506 T4405 T4399 appos raclopride,antagonist
R2507 T4406 T4394 punct ", ",improves
R2508 T4407 T4394 advmod actually,improves
R2509 T4408 T4394 dobj acquisition,improves
R2510 T4409 T4408 prep of,acquisition
R2511 T4410 T4411 npadvmod food,motivated
R2512 T4411 T4413 amod motivated,learning
R2513 T4412 T4411 punct -,motivated
R2514 T4413 T4409 pobj learning,of
R2515 T4414 T4413 amod associative,learning
R2516 T4415 T4416 punct [,6
R2517 T4416 T4388 parataxis 6,reported
R2518 T4417 T4416 punct ],6
R2519 T4418 T4388 punct .,reported
R2520 T4420 T4421 advmod However,given
R2521 T4422 T4421 punct ", ",given
R2522 T4423 T4424 advmod only,administrations
R2523 T4424 T4421 nsubjpass administrations,given
R2524 T4425 T4424 amod acute,administrations
R2525 T4426 T4424 prep of,administrations
R2526 T4427 T4426 pobj antagonists,of
R2527 T4428 T4421 auxpass were,given
R2528 T4429 T4421 punct ", ",given
R2529 T4430 T4421 cc and,given
R2530 T4431 T4432 nsubjpass learning,measured
R2531 T4432 T4421 conj measured,given
R2532 T4433 T4432 auxpass was,measured
R2533 T4434 T4432 neg not,measured
R2534 T4435 T4432 prep during,measured
R2535 T4436 T4437 amod complete,blockade
R2536 T4437 T4435 pobj blockade,during
R2537 T4438 T4437 nmod D1R,blockade
R2538 T4439 T4438 cc or,D1R
R2539 T4440 T4438 conj D2R,D1R
R2540 T4441 T4442 punct [,6
R2541 T4442 T4432 parataxis 6,measured
R2542 T4443 T4442 punct ],6
R2543 T4444 T4421 punct .,given
R2544 T4446 T4447 advmod Significantly,failed
R2545 T4448 T4447 punct ", ",failed
R2546 T4449 T4450 det the,reports
R2547 T4450 T4447 nsubj reports,failed
R2548 T4451 T4450 acl cited,reports
R2549 T4452 T4451 advmod above,cited
R2550 T4453 T4454 aux to,address
R2551 T4454 T4447 xcomp address,failed
R2552 T4455 T4456 det the,limitations
R2553 T4456 T4454 dobj limitations,address
R2554 T4457 T4456 amod technical,limitations
R2555 T4458 T4456 prep of,limitations
R2556 T4459 T4460 det the,approach
R2557 T4460 T4458 pobj approach,of
R2558 T4461 T4456 punct : ,limitations
R2559 T4462 T4463 advmod i.e.,lack
R2560 T4463 T4456 acl lack,limitations
R2561 T4464 T4463 mark that,lack
R2562 T4465 T4466 det the,antagonists
R2563 T4466 T4463 nsubj antagonists,lack
R2564 T4467 T4466 acl used,antagonists
R2565 T4468 T4469 amod adequate,specificity
R2566 T4469 T4463 dobj specificity,lack
R2567 T4470 T4469 compound subtype,specificity
R2568 T4471 T4463 cc and,lack
R2569 T4472 T4473 advmod only,partially
R2570 T4473 T4474 advmod partially,blocked
R2571 T4474 T4463 conj blocked,lack
R2572 T4475 T4476 npadvmod D2R,mediated
R2573 T4476 T4478 amod mediated,signaling
R2574 T4477 T4476 punct -,mediated
R2575 T4478 T4474 dobj signaling,blocked
R2576 T4479 T4480 advmod thus,making
R2577 T4480 T4463 advcl making,lack
R2578 T4481 T4482 nsubj it,impossible
R2579 T4482 T4480 ccomp impossible,making
R2580 T4483 T4484 aux to,assess
R2581 T4484 T4482 advcl assess,impossible
R2582 T4485 T4484 advmod rigorously,assess
R2583 T4486 T4487 det the,role
R2584 T4487 T4484 dobj role,assess
R2585 T4488 T4487 prep of,role
R2586 T4489 T4490 npadvmod D2R,mediated
R2587 T4490 T4492 amod mediated,signaling
R2588 T4491 T4490 punct -,mediated
R2589 T4492 T4488 pobj signaling,of
R2590 T4493 T4487 prep in,role
R2591 T4494 T4495 amod associative,learning
R2592 T4495 T4493 pobj learning,in
R2593 T4496 T4494 cc and,associative
R2594 T4497 T4494 conj reversal,associative
R2595 T4498 T4447 punct .,failed
R2596 T4500 T4501 advmod Additionally,addressed
R2597 T4502 T4501 punct ", ",addressed
R2598 T4503 T4501 nsubj none,addressed
R2599 T4504 T4503 prep of,none
R2600 T4505 T4506 det these,studies
R2601 T4506 T4504 pobj studies,of
R2602 T4507 T4508 det the,observation
R2603 T4508 T4501 dobj observation,addressed
R2604 T4509 T4510 mark that,depend
R2605 T4510 T4508 acl depend,observation
R2606 T4511 T4512 det the,effects
R2607 T4512 T4510 nsubj effects,depend
R2608 T4513 T4512 prep of,effects
R2609 T4514 T4515 compound D2R,antagonists
R2610 T4515 T4513 pobj antagonists,of
R2611 T4516 T4512 prep on,effects
R2612 T4517 T4516 pobj locomotion,on
R2613 T4518 T4517 cc and,locomotion
R2614 T4519 T4517 conj learning,locomotion
R2615 T4520 T4510 prep on,depend
R2616 T4521 T4522 mark whether,is
R2617 T4522 T4520 pcomp is,on
R2618 T4523 T4522 nsubj exposure,is
R2619 T4524 T4522 acomp chronic,is
R2620 T4525 T4524 cc or,chronic
R2621 T4526 T4524 conj acute,chronic
R2622 T4527 T4528 punct [,16
R2623 T4528 T4501 parataxis 16,addressed
R2624 T4529 T4528 advmod e.g.,16
R2625 T4530 T4528 punct [,16
R2626 T4531 T4528 nummod 15,16
R2627 T4532 T4528 punct ",",16
R2628 T4533 T4528 punct ],16
R2629 T4534 T4528 punct ],16
R2630 T4535 T4501 punct .,addressed
R2631 T4537 T4538 mark That,orchestrates
R2632 T4538 T4543 csubj orchestrates,is
R2633 T4539 T4540 npadvmod D2R,mediated
R2634 T4540 T4542 amod mediated,signaling
R2635 T4541 T4540 punct -,mediated
R2636 T4542 T4538 nsubj signaling,orchestrates
R2637 T4544 T4545 advmod just,components
R2638 T4545 T4538 dobj components,orchestrates
R2639 T4546 T4545 amod motor,components
R2640 T4547 T4545 prep of,components
R2641 T4548 T4547 pobj learning,of
R2642 T4549 T4550 det a,conclusion
R2643 T4550 T4543 attr conclusion,is
R2644 T4551 T4552 dep that,is
R2645 T4552 T4550 relcl is,conclusion
R2646 T4553 T4552 advmod potentially,is
R2647 T4554 T4552 acomp biased,is
R2648 T4555 T4552 prep due,is
R2649 T4556 T4555 pcomp to,due
R2650 T4557 T4558 det the,practice
R2651 T4558 T4555 pobj practice,due
R2652 T4559 T4558 prep of,practice
R2653 T4560 T4559 pobj avoiding,of
R2654 T4561 T4560 dobj doses,avoiding
R2655 T4562 T4561 prep of,doses
R2656 T4563 T4562 pobj drugs,of
R2657 T4564 T4565 dep that,induce
R2658 T4565 T4561 relcl induce,doses
R2659 T4566 T4565 dobj catalepsy,induce
R2660 T4567 T4560 punct (,avoiding
R2661 T4568 T4560 cc and,avoiding
R2662 T4569 T4570 advmod therefore,measuring
R2663 T4570 T4560 conj measuring,avoiding
R2664 T4571 T4572 advmod only,blockade
R2665 T4572 T4570 dobj blockade,measuring
R2666 T4573 T4572 amod partial,blockade
R2667 T4574 T4572 prep of,blockade
R2668 T4575 T4576 compound dopamine,D2Rs
R2669 T4576 T4574 pobj D2Rs,of
R2670 T4577 T4560 punct ),avoiding
R2671 T4578 T4560 cc and,avoiding
R2672 T4579 T4580 amod single,administrations
R2673 T4580 T4560 conj administrations,avoiding
R2674 T4581 T4582 punct [,3
R2675 T4582 T4543 parataxis 3,is
R2676 T4583 T4582 advmod e.g.,3
R2677 T4584 T4582 punct [,3
R2678 T4585 T4582 punct ],3
R2679 T4586 T4582 punct ],3
R2680 T4587 T4543 punct .,is
R2681 T4589 T4590 advmod Quite,possibly
R2682 T4590 T4591 advmod possibly,masked
R2683 T4592 T4591 punct ", ",masked
R2684 T4593 T4594 det the,role
R2685 T4594 T4591 nsubjpass role,masked
R2686 T4595 T4594 amod functional,role
R2687 T4596 T4594 prep of,role
R2688 T4597 T4596 pobj D2Rs,of
R2689 T4598 T4594 prep in,role
R2690 T4599 T4600 amod associative,learning
R2691 T4600 T4598 pobj learning,in
R2692 T4601 T4591 aux might,masked
R2693 T4602 T4591 auxpass be,masked
R2694 T4603 T4604 advmod because,of
R2695 T4604 T4591 prep of,masked
R2696 T4605 T4606 det this,concern
R2697 T4606 T4604 pobj concern,of
R2698 T4607 T4606 prep about,concern
R2699 T4608 T4609 compound locomotor,disruption
R2700 T4609 T4607 pobj disruption,about
R2701 T4610 T4611 punct [,8
R2702 T4611 T4591 parataxis 8,masked
R2703 T4612 T4611 nummod 2,8
R2704 T4613 T4611 punct ",",8
R2705 T4614 T4611 nummod 6,8
R2706 T4615 T4611 punct ",",8
R2707 T4616 T4611 punct ],8
R2708 T4617 T4591 punct .,masked
R2709 T4619 T4620 nsubj Doses,disrupt
R2710 T4621 T4619 prep of,Doses
R2711 T4622 T4621 pobj raclopride,of
R2712 T4623 T4624 advmod as,0.5
R2713 T4624 T4627 nummod 0.5,mg
R2714 T4625 T4624 amod low,0.5
R2715 T4626 T4624 quantmod as,0.5
R2716 T4627 T4619 appos mg,Doses
R2717 T4628 T4629 punct /,kg
R2718 T4629 T4627 prep kg,mg
R2719 T4630 T4620 advmod significantly,disrupt
R2720 T4631 T4632 amod motor,behavior
R2721 T4632 T4620 dobj behavior,disrupt
R2722 T4633 T4634 punct [,25
R2723 T4634 T4620 parataxis 25,disrupt
R2724 T4635 T4634 punct ],25
R2725 T4636 T4620 punct ", ",disrupt
R2726 T4637 T4638 mark although,used
R2727 T4638 T4620 advcl used,disrupt
R2728 T4639 T4640 det this,dose
R2729 T4640 T4638 nsubjpass dose,used
R2730 T4641 T4640 amod peripheral,dose
R2731 T4642 T4638 auxpass is,used
R2732 T4643 T4638 advmod consistently,used
R2733 T4644 T4638 prep in,used
R2734 T4645 T4646 amod learning,paradigms
R2735 T4646 T4644 pobj paradigms,in
R2736 T4647 T4648 punct [,6
R2737 T4648 T4638 parataxis 6,used
R2738 T4649 T4648 advmod e.g.,6
R2739 T4650 T4648 punct [,6
R2740 T4651 T4648 punct ],6
R2741 T4652 T4648 punct ],6
R2742 T4653 T4620 punct .,disrupt
R2743 T4655 T4656 nsubj One,ask
R2744 T4657 T4656 aux might,ask
R2745 T4658 T4656 advmod then,ask
R2746 T4659 T4656 punct : ,ask
R2747 T4660 T4656 punct """",ask
R2748 T4661 T4662 advmod How,dissociated
R2749 T4662 T4656 ccomp dissociated,ask
R2750 T4663 T4662 advmod then,dissociated
R2751 T4664 T4662 aux could,dissociated
R2752 T4665 T4666 det the,role
R2753 T4666 T4662 nsubjpass role,dissociated
R2754 T4667 T4666 prep of,role
R2755 T4668 T4667 pobj D2Rs,of
R2756 T4669 T4666 prep in,role
R2757 T4670 T4671 amod associative,learning
R2758 T4671 T4669 pobj learning,in
R2759 T4672 T4662 auxpass be,dissociated
R2760 T4673 T4662 prep from,dissociated
R2761 T4674 T4675 amod motor,behavior
R2762 T4675 T4673 pobj behavior,from
R2763 T4676 T4656 punct ?,ask
R2764 T4677 T4656 punct """",ask
R2765 T4679 T4680 amod Seminal,experiments
R2766 T4680 T4681 nsubj experiments,demonstrated
R2767 T4682 T4683 punct [,26
R2768 T4683 T4680 parataxis 26,experiments
R2769 T4684 T4685 punct -,28
R2770 T4685 T4683 prep 28,26
R2771 T4686 T4683 punct ],26
R2772 T4687 T4681 aux have,demonstrated
R2773 T4688 T4681 advmod clearly,demonstrated
R2774 T4689 T4690 mark that,leads
R2775 T4690 T4681 ccomp leads,demonstrated
R2776 T4691 T4692 amod repeated,administration
R2777 T4692 T4690 nsubj administration,leads
R2778 T4693 T4692 prep of,administration
R2779 T4694 T4695 npadvmod catalepsy,inducing
R2780 T4695 T4697 amod inducing,doses
R2781 T4696 T4695 punct -,inducing
R2782 T4697 T4693 pobj doses,of
R2783 T4698 T4697 prep of,doses
R2784 T4699 T4700 compound D2R,antagonists
R2785 T4700 T4698 pobj antagonists,of
R2786 T4701 T4692 prep in,administration
R2787 T4702 T4701 pobj rodents,in
R2788 T4703 T4690 advmod actually,leads
R2789 T4704 T4690 prep to,leads
R2790 T4705 T4706 det a,tolerance
R2791 T4706 T4704 pobj tolerance,to
R2792 T4707 T4706 amod striking,tolerance
R2793 T4708 T4706 amod behavioral,tolerance
R2794 T4709 T4706 prep to,tolerance
R2795 T4710 T4709 pobj catalepsy,to
R2796 T4711 T4681 punct .,demonstrated
R2797 T4713 T4714 det These,doses
R2798 T4714 T4715 nsubjpass doses,shown
R2799 T4716 T4715 aux have,shown
R2800 T4717 T4715 auxpass been,shown
R2801 T4718 T4719 aux to,occupy
R2802 T4719 T4715 xcomp occupy,shown
R2803 T4720 T4721 advmod well,80
R2804 T4721 T4723 nummod 80,%
R2805 T4722 T4721 quantmod over,80
R2806 T4723 T4719 dobj %,occupy
R2807 T4724 T4723 prep of,%
R2808 T4725 T4726 amod available,D2Rs
R2809 T4726 T4724 pobj D2Rs,of
R2810 T4727 T4728 punct [,29
R2811 T4728 T4715 parataxis 29,shown
R2812 T4729 T4728 punct ],29
R2813 T4730 T4715 punct .,shown
R2814 T4732 T4733 amod Future,experiments
R2815 T4733 T4734 nsubj experiments,be
R2816 T4735 T4733 acl measuring,experiments
R2817 T4736 T4735 dobj acquisition,measuring
R2818 T4737 T4736 prep of,acquisition
R2819 T4738 T4739 amod associative,learning
R2820 T4739 T4737 pobj learning,of
R2821 T4740 T4735 prep in,measuring
R2822 T4741 T4740 pobj rodents,in
R2823 T4742 T4743 dep that,received
R2824 T4743 T4741 relcl received,rodents
R2825 T4744 T4745 amod chronic,administration
R2826 T4745 T4743 dobj administration,received
R2827 T4746 T4745 prep of,administration
R2828 T4747 T4748 compound D2R,antagonists
R2829 T4748 T4746 pobj antagonists,of
R2830 T4749 T4743 cc and,received
R2831 T4750 T4743 conj demonstrated,received
R2832 T4751 T4752 amod behavioral,tolerance
R2833 T4752 T4750 dobj tolerance,demonstrated
R2834 T4753 T4752 prep to,tolerance
R2835 T4754 T4755 poss their,effects
R2836 T4755 T4753 pobj effects,to
R2837 T4756 T4755 nmod motor,effects
R2838 T4757 T4755 amod disrupting,effects
R2839 T4758 T4734 aux would,be
R2840 T4759 T4760 det a,test
R2841 T4760 T4734 attr test,be
R2842 T4761 T4760 amod logical,test
R2843 T4762 T4760 prep of,test
R2844 T4763 T4764 det this,hypothesis
R2845 T4764 T4762 pobj hypothesis,of
R2846 T4765 T4734 punct .,be
R2847 T4767 T4768 advmod However,have
R2848 T4769 T4768 punct ", ",have
R2849 T4770 T4771 det the,realization
R2850 T4771 T4768 nsubj realization,have
R2851 T4772 T4773 mark that,targeted
R2852 T4773 T4771 acl targeted,realization
R2853 T4774 T4775 amod multiple,subtypes
R2854 T4775 T4773 nsubjpass subtypes,targeted
R2855 T4776 T4777 compound dopamine,receptor
R2856 T4777 T4775 compound receptor,subtypes
R2857 T4778 T4773 aux would,targeted
R2858 T4863 T4862 amod parental,strain
R2859 T4779 T4773 auxpass be,targeted
R2860 T4864 T4858 prep for,backcrossed
R2861 T4780 T4773 advmod concurrently,targeted
R2862 T4865 T4866 det a,minimum
R2863 T4866 T4864 pobj minimum,for
R2864 T4867 T4866 prep of,minimum
R2865 T4781 T4773 prep with,targeted
R2866 T4868 T4869 nummod 10,generations
R2867 T4869 T4867 pobj generations,of
R2868 T4782 T4783 det the,antagonists
R2869 T4870 T4848 punct ),compensation
R2870 T4871 T4844 punct ", ",revealed
R2871 T4872 T4844 nsubj use,revealed
R2872 T4783 T4781 pobj antagonists,with
R2873 T4873 T4872 prep of,use
R2874 T4874 T4875 poss our,animals
R2875 T4875 T4873 pobj animals,of
R2876 T4784 T4785 advmod presently,available
R2877 T4876 T4875 amod inbred,animals
R2878 T4877 T4878 punct (,generation
R2879 T4785 T4783 amod available,antagonists
R2880 T4878 T4875 parataxis generation,animals
R2881 T4879 T4878 compound N20,generation
R2882 T4880 T4878 punct ),generation
R2883 T4786 T4785 advmod commercially,available
R2884 T4881 T4872 prep in,use
R2885 T4882 T4883 det the,study
R2886 T4883 T4881 pobj study,in
R2887 T4787 T4783 punct ", ",antagonists
R2888 T4884 T4883 amod present,study
R2889 T4885 T4883 punct (,study
R2890 T4886 T4887 advmod where,detected
R2891 T4788 T4789 amod such,as
R2892 T4887 T4883 relcl detected,study
R2893 T4888 T4889 det no,differences
R2894 T4789 T4783 prep as,antagonists
R2895 T4889 T4887 nsubjpass differences,detected
R2896 T4890 T4889 prep in,differences
R2897 T4891 T4892 compound locomotor,behavior
R2898 T4790 T4789 pobj D2Rs,as
R2899 T4892 T4890 pobj behavior,in
R2900 T4791 T4790 punct ", ",D2Rs
R2901 T4893 T4887 auxpass were,detected
R2902 T4894 T4887 prep between,detected
R2903 T4895 T4896 nmod D2R,mice
R2904 T4792 T4790 conj D3Rs,D2Rs
R2905 T4896 T4894 pobj mice,between
R2906 T4793 T4792 punct ", ",D3Rs
R2907 T4897 T4895 punct -,D2R
R2908 T4898 T4895 punct /,D2R
R2909 T4794 T4792 cc and,D3Rs
R2910 T4899 T4895 punct -,D2R
R2911 T4900 T4895 cc and,D2R
R2912 T4901 T4895 conj D2R,D2R
R2913 T4902 T4901 punct +,D2R
R2914 T4903 T4901 punct /,D2R
R2915 T4795 T4792 conj D4Rs,D3Rs
R2916 T4904 T4901 punct +,D2R
R2917 T4905 T4906 punct ;,Figs.
R2918 T4906 T4872 parataxis Figs.,use
R2919 T4796 T4768 aux would,have
R2920 T4907 T4906 nummod 1,Figs.
R2921 T4908 T4906 cc &,Figs.
R2922 T4797 T4798 aux to,rectified
R2923 T4909 T4906 conj 2,Figs.
R2924 T4910 T4906 punct ),Figs.
R2925 T4911 T4912 det a,role
R2926 T4798 T4768 xcomp rectified,have
R2927 T4912 T4844 dobj role,revealed
R2928 T4913 T4914 advmod previously,unappreciated
R2929 T4914 T4912 amod unappreciated,role
R2930 T4799 T4798 auxpass be,rectified
R2931 T4915 T4912 prep of,role
R2932 T4916 T4917 npadvmod D2R,mediated
R2933 T4800 T4768 punct .,have
R2934 T4917 T4919 amod mediated,signaling
R2935 T4918 T4917 punct -,mediated
R2936 T4919 T4915 pobj signaling,of
R2937 T4802 T4803 nsubj We,argue
R2938 T4920 T4912 prep in,role
R2939 T4921 T4922 amod associative,learning
R2940 T4922 T4920 pobj learning,in
R2941 T4923 T4922 cc and,learning
R2942 T4804 T4803 aux would,argue
R2943 T4924 T4922 conj attention,learning
R2944 T4925 T4926 dep that,measured
R2945 T4926 T4912 relcl measured,role
R2946 T4805 T4806 mark that,is
R2947 T4927 T4926 aux could,measured
R2948 T4928 T4926 neg not,measured
R2949 T4929 T4926 auxpass be,measured
R2950 T4806 T4803 ccomp is,argue
R2951 T4930 T4926 prep with,measured
R2952 T4931 T4932 det the,antagonists
R2953 T4807 T4808 det the,approach
R2954 T4932 T4930 pobj antagonists,with
R2955 T4933 T4934 advmod currently,available
R2956 T4934 T4932 amod available,antagonists
R2957 T4808 T4806 nsubj approach,is
R2958 T4935 T4932 punct ", ",antagonists
R2959 T4936 T4937 advmod acutely,administered
R2960 T4809 T4810 advmod most,parsimonious
R2961 T4937 T4932 amod administered,antagonists
R2962 T4938 T4932 compound D2R,antagonists
R2963 T4939 T4844 punct .,revealed
R2964 T4941 T4942 det A,analysis
R2965 T4942 T4944 nsubj analysis,suggest
R2966 T4810 T4808 amod parsimonious,approach
R2967 T4943 T4942 amod cursory,analysis
R2968 T4945 T4942 prep of,analysis
R2969 T4811 T4808 prep at,approach
R2970 T4946 T4947 poss our,data
R2971 T4947 T4945 pobj data,of
R2972 T4812 T4813 det this,time
R2973 T4948 T4944 aux might,suggest
R2974 T4949 T4944 prep to,suggest
R2975 T4950 T4949 pobj some,to
R2976 T4813 T4811 pobj time,at
R2977 T4951 T4952 mark that,conferred
R2978 T4952 T4944 ccomp conferred,suggest
R2979 T4814 T4815 aux to,utilize
R2980 T4953 T4954 det the,manipulation
R2981 T4954 T4952 nsubj manipulation,conferred
R2982 T4955 T4954 amod genetic,manipulation
R2983 T4815 T4806 xcomp utilize,is
R2984 T4956 T4954 prep of,manipulation
R2985 T4957 T4958 det the,locus
R2986 T4958 T4956 pobj locus,of
R2987 T4816 T4815 dobj mice,utilize
R2988 T4959 T4958 compound drd2,locus
R2989 T4960 T4961 det a,impairment
R2990 T4817 T4818 dep that,altered
R2991 T4961 T4952 dobj impairment,conferred
R2992 T4962 T4961 amod gross,impairment
R2993 T4963 T4961 amod olfactory,impairment
R2994 T4818 T4816 relcl altered,mice
R2995 T4964 T4952 prep to,conferred
R2996 T4965 T4966 det the,mice
R2997 T4819 T4818 aux have,altered
R2998 T4966 T4964 pobj mice,to
R2999 T4967 T4966 nmod D2R,mice
R3000 T4968 T4967 punct -,D2R
R3001 T4820 T4818 auxpass been,altered
R3002 T4821 T4818 advmod genetically,altered
R3003 T4822 T4823 amod such,lacking
R3004 T4823 T4818 advcl lacking,altered
R3005 T4969 T4967 punct /,D2R
R3006 T4824 T4823 mark that,lacking
R3007 T4970 T4967 punct -,D2R
R3008 T4971 T4944 punct .,suggest
R3009 T4825 T4823 nsubj they,lacking
R3010 T4973 T4974 advmod Rather,argue
R3011 T4826 T4823 aux are,lacking
R3012 T4975 T4974 punct ", ",argue
R3013 T4827 T4828 nummod one,alleles
R3014 T4976 T4974 nsubj we,argue
R3015 T4977 T4978 mark that,is
R3016 T4978 T4974 ccomp is,argue
R3017 T4979 T4978 nsubj this,is
R3018 T4980 T4978 neg not,is
R3019 T4981 T4978 acomp likely,is
R3020 T4982 T4983 mark because,learn
R3021 T4828 T4823 dobj alleles,lacking
R3022 T4983 T4978 advcl learn,is
R3023 T4829 T4827 cc or,one
R3025 T4985 T4983 nsubj mice,learn
R3026 T4830 T4827 conj both,one
R3027 T4986 T4985 nmod D2R,mice
R3028 T4987 T4986 punct -,D2R
R3029 T4988 T4986 punct /,D2R
R3030 T4831 T4828 amod functional,alleles
R3031 T4989 T4986 punct -,D2R
R3032 T4990 T4983 aux did,learn
R3033 T4991 T4992 aux to,retrieve
R3034 T4832 T4828 prep of,alleles
R3035 T4992 T4983 xcomp retrieve,learn
R3036 T4833 T4834 det the,receptor
R3037 T4834 T4832 pobj receptor,of
R3038 T4993 T4994 det the,pellets
R3039 T4835 T4834 amod specific,receptor
R3040 T4994 T4992 dobj pellets,retrieve
R3041 T4836 T4834 prep of,receptor
R3042 T4995 T4994 compound food,pellets
R3043 T4996 T4992 prep from,retrieve
R3044 T4837 T4836 pobj interest,of
R3045 T4997 T4998 det the,dishes
R3046 T4998 T4996 pobj dishes,from
R3047 T4999 T4983 cc and,learn
R3048 T4838 T4803 punct .,argue
R3049 T5000 T5001 advmod eventually,learned
R3050 T5001 T4983 conj learned,learn
R3051 T4840 T4841 mark While,have
R3052 T5002 T5003 aux to,discriminate
R3053 T5003 T5001 xcomp discriminate,learned
R3054 T5004 T5003 advmod accurately,discriminate
R3055 T5005 T5003 dobj odors,discriminate
R3056 T4841 T4844 advcl have,revealed
R3057 T5006 T4974 punct .,argue
R3058 T4842 T4841 nsubj they,have
R3059 T5008 T5009 amod Recent,data
R3060 T5009 T5011 nsubj data,demonstrate
R3061 T5010 T5009 amod electrophysiological,data
R3062 T4843 T4841 aux do,have
R3063 T5012 T5013 mark that,located
R3064 T4845 T4846 poss their,limitations
R3065 T5013 T5011 ccomp located,demonstrate
R3066 T5014 T5015 compound dopamine,D2R's
R3067 T5015 T5013 nsubjpass D2R's,located
R3068 T5016 T5013 auxpass are,located
R3069 T5017 T5013 prep on,located
R3070 T5018 T5019 amod glutamatergic,axons
R3071 T4846 T4841 dobj limitations,have
R3072 T5019 T5017 pobj axons,on
R3073 T5020 T5019 amod terminal,axons
R3074 T5021 T5019 prep of,axons
R3075 T4847 T4848 punct (,compensation
R3076 T5022 T5023 amod olfactory,nerves
R3077 T5023 T5021 pobj nerves,of
R3078 T5024 T5013 cc and,located
R3079 T4848 T4846 appos compensation,limitations
R3080 T5025 T5013 conj depress,located
R3081 T5026 T5027 amod excitatory,input
R3082 T5027 T5025 dobj input,depress
R3083 T4849 T4848 advmod e.g.,compensation
R3084 T5028 T5027 prep of,input
R3085 T5029 T5030 det the,nerve
R3086 T4850 T4848 amod developmental,compensation
R3087 T4851 T4848 cc and,compensation
R3088 T5030 T5028 pobj nerve,of
R3089 T4852 T4853 compound strain,effects
R3090 T5031 T5030 amod olfactory,nerve
R3091 T5032 T5027 prep to,input
R3092 T5033 T5034 det the,cells
R3093 T4853 T4848 conj effects,compensation
R3094 T5034 T5032 pobj cells,to
R3095 T5035 T5034 amod mitral,cells
R3096 T5036 T5034 prep of,cells
R3097 T4854 T4848 prep in,compensation
R3098 T5037 T5038 det the,bulb
R3099 T5038 T5036 pobj bulb,of
R3100 T5039 T5038 amod olfactory,bulb
R3101 T4855 T4856 compound mouse,lines
R3102 T5040 T5041 punct [,31
R3103 T5041 T5025 parataxis 31,depress
R3104 T5042 T5041 nummod 30,31
R3105 T4856 T4854 pobj lines,in
R3106 T5043 T5041 punct ",",31
R3107 T5044 T5041 punct ],31
R3108 T5045 T5011 punct .,demonstrate
R3109 T4857 T4858 neg not,backcrossed
R3110 T5047 T5048 advmod Consequently,suggest
R3111 T4858 T4856 acl backcrossed,lines
R3112 T5048 T5059 ccomp suggest,affects
R3113 T5049 T5048 punct ", ",suggest
R3114 T5050 T5051 poss our,data
R3115 T4859 T4858 advmod adequately,backcrossed
R3116 T5051 T5048 nsubj data,suggest
R3117 T5052 T5051 punct ", ",data
R3118 T5053 T5051 cc and,data
R3119 T5054 T5051 conj data,data
R3120 T5055 T5054 prep from,data
R3121 T5056 T5057 amod other,studies
R3122 T4860 T4858 prep to,backcrossed
R3123 T5057 T5055 pobj studies,from
R3124 T5058 T5048 punct ", ",suggest
R3125 T4861 T4862 det a,strain
R3126 T5060 T5061 mark that,prevent
R3127 T4862 T4860 pobj strain,to
R3128 T5061 T5048 ccomp prevent,suggest
R3129 T5075 T5076 amod olfactory,stimuli
R3130 T5062 T5063 det the,lack
R3131 T5063 T5061 nsubj lack,prevent
R3132 T5064 T5063 amod complete,lack
R3133 T5065 T5063 prep of,lack
R3134 T5066 T5065 pobj D2Rs,of
R3135 T5076 T5074 pobj stimuli,of
R3136 T5067 T5063 prep in,lack
R3137 T5068 T5069 det the,bulb
R3138 T5069 T5067 pobj bulb,in
R3139 T5077 T5059 punct ;,affects
R3140 T5070 T5069 amod olfactory,bulb
R3141 T5071 T5061 aux does,prevent
R3142 T5078 T5059 advmod rather,affects
R3143 T5072 T5061 neg not,prevent
R3144 T5073 T5061 dobj transduction,prevent
R3145 T5074 T5073 prep of,transduction
R3146 T5079 T5059 nsubj it,affects
R3147 T5080 T5081 det the,ability
R3148 T5081 T5059 dobj ability,affects
R3149 T5082 T5083 aux to,habituate
R3150 T5083 T5081 acl habituate,ability
R3151 T5181 T5180 acomp significant,are
R3152 T5182 T5183 mark because,respond
R3153 T5084 T5083 punct ", ",habituate
R3154 T5183 T5180 advcl respond,are
R3155 T5184 T5185 nmod D2R,mice
R3156 T5185 T5183 nsubj mice,respond
R3157 T5085 T5083 cc or,habituate
R3158 T5186 T5184 punct -,D2R
R3159 T5187 T5184 punct /,D2R
R3160 T5188 T5184 punct -,D2R
R3161 T5086 T5083 conj tune,habituate
R3162 T5189 T5183 prep to,respond
R3163 T5190 T5191 compound food,reinforcers
R3164 T5087 T5086 punct ", ",tune
R3165 T5191 T5189 pobj reinforcers,to
R3166 T5192 T5183 cc and,respond
R3167 T5193 T5194 advmod ultimately,form
R3168 T5088 T5089 amod olfactory,nerve
R3169 T5194 T5183 conj form,respond
R3170 T5195 T5194 cc and,form
R3171 T5196 T5194 conj maintain,form
R3172 T5197 T5198 npadvmod odor,driven
R3173 T5198 T5200 amod driven,relationships
R3174 T5199 T5198 punct -,driven
R3175 T5089 T5090 compound nerve,activity
R3176 T5200 T5196 dobj relationships,maintain
R3177 T5201 T5200 nmod S,relationships
R3178 T5202 T5201 punct +,S
R3179 T5090 T5086 conj activity,tune
R3180 T5203 T5201 punct /,S
R3181 T5091 T5090 acl associated,activity
R3182 T5204 T5201 appos S,S
R3183 T5205 T5204 punct -,S
R3184 T5206 T5207 punct (,behavior
R3185 T5207 T5200 appos behavior,relationships
R3186 T5092 T5091 prep with,associated
R3187 T5208 T5207 det a,behavior
R3188 T5209 T5207 amod putative,behavior
R3189 T5093 T5094 advmod repeatedly,encountered
R3190 T5210 T5211 npadvmod D1R,mediated
R3191 T5211 T5207 amod mediated,behavior
R3192 T5212 T5211 punct -,mediated
R3193 T5094 T5095 amod encountered,concentrations
R3194 T5213 T5214 punct [,6
R3195 T5214 T5196 parataxis 6,maintain
R3196 T5215 T5214 punct ],6
R3197 T5095 T5092 pobj concentrations,with
R3198 T5216 T5196 punct ),maintain
R3199 T5217 T5218 advmod just,as
R3200 T5218 T5183 prep as,respond
R3201 T5096 T5095 prep of,concentrations
R3202 T5219 T5220 nmod D2R,mice
R3203 T5220 T5218 pobj mice,as
R3204 T5221 T5219 punct +,D2R
R3205 T5097 T5098 amod chemical,stimuli
R3206 T5222 T5219 punct /,D2R
R3207 T5223 T5219 punct +,D2R
R3208 T5224 T5225 punct (,targeted
R3209 T5098 T5096 pobj stimuli,of
R3210 T5099 T5100 punct [,32
R3211 T5225 T5220 parataxis targeted,mice
R3212 T5226 T5227 det both,groups
R3213 T5100 T5059 parataxis 32,affects
R3214 T5227 T5228 nsubj groups,achieved
R3215 T5228 T5225 ccomp achieved,targeted
R3216 T5229 T5230 punct ≥,80
R3217 T5101 T5100 punct ],32
R3218 T5230 T5231 nummod 80,%
R3219 T5231 T5232 compound %,accuracy
R3220 T5232 T5228 dobj accuracy,achieved
R3221 T5102 T5059 punct .,affects
R3222 T5233 T5232 compound discrimination,accuracy
R3223 T5234 T5225 punct ", ",targeted
R3224 T5235 T5236 det the,D1Rs
R3225 T5236 T5225 nsubjpass D1Rs,targeted
R3226 T5237 T5236 compound dopamine,D1Rs
R3227 T5238 T5236 prep in,D1Rs
R3228 T5104 T5105 det The,performance
R3229 T5239 T5240 poss our,mice
R3230 T5240 T5238 pobj mice,in
R3231 T5241 T5225 auxpass were,targeted
R3232 T5242 T5225 neg not,targeted
R3233 T5105 T5106 nsubj performance,is
R3234 T5243 T5225 punct ),targeted
R3235 T5244 T5180 punct .,are
R3236 T5107 T5105 prep of,performance
R3237 T5246 T5247 det A,extension
R3238 T5247 T5249 nsubj extension,be
R3239 T5108 T5109 nmod D2R,mice
R3240 T5248 T5247 amod future,extension
R3241 T5250 T5247 prep of,extension
R3242 T5109 T5107 pobj mice,of
R3243 T5251 T5252 det this,study
R3244 T5252 T5250 pobj study,of
R3245 T5110 T5108 punct -,D2R
R3246 T5253 T5249 aux would,be
R3247 T5254 T5255 aux to,test
R3248 T5255 T5249 xcomp test,be
R3249 T5111 T5108 punct /,D2R
R3250 T5256 T5255 dobj performance,test
R3251 T5257 T5256 prep over,performance
R3252 T5258 T5259 det a,number
R3253 T5112 T5108 punct -,D2R
R3254 T5259 T5257 pobj number,over
R3255 T5260 T5259 amod fixed,number
R3256 T5261 T5259 prep of,number
R3257 T5113 T5105 prep during,performance
R3258 T5262 T5261 pobj trials,of
R3259 T5263 T5255 cc and,test
R3260 T5264 T5255 conj determine,test
R3261 T5114 T5115 compound reversal,learning
R3262 T5265 T5264 dobj patterns,determine
R3263 T5266 T5265 prep of,patterns
R3264 T5267 T5268 compound error,rates
R3265 T5115 T5113 pobj learning,during
R3266 T5268 T5266 pobj rates,of
R3267 T5269 T5264 prep during,determine
R3268 T5270 T5269 pobj acquisition,during
R3269 T5116 T5106 acomp deficient,is
R3270 T5271 T5270 prep of,acquisition
R3271 T5272 T5273 det the,tasks
R3272 T5117 T5106 advcl revealing,is
R3273 T5273 T5271 pobj tasks,of
R3274 T5274 T5273 nmod discrimination,tasks
R3275 T5275 T5274 cc and,discrimination
R3276 T5276 T5274 conj reversal,discrimination
R3277 T5277 T5273 compound learning,tasks
R3278 T5278 T5249 punct .,be
R3279 T5280 T5281 det This,manipulation
R3280 T5281 T5282 nsubj manipulation,control
R3281 T5283 T5282 aux would,control
R3282 T5284 T5285 det the,number
R3283 T5118 T5119 det a,role
R3284 T5285 T5282 dobj number,control
R3285 T5119 T5117 dobj role,revealing
R3286 T5120 T5119 prep for,role
R3287 T5121 T5122 compound dopamine,D2R
R3288 T5286 T5285 prep of,number
R3289 T5287 T5286 pobj errors,of
R3290 T5122 T5123 npadvmod D2R,mediated
R3291 T5288 T5282 prep based,control
R3292 T5289 T5288 prep on,based
R3293 T5290 T5289 pobj trials,on
R3294 T5123 T5125 amod mediated,signaling
R3295 T5291 T5290 acl performed,trials
R3296 T5292 T5293 aux to,determine
R3297 T5293 T5282 advcl determine,control
R3298 T5124 T5123 punct -,mediated
R3299 T5294 T5295 mark if,is
R3300 T5295 T5293 ccomp is,determine
R3301 T5296 T5297 det the,difference
R3302 T5125 T5120 pobj signaling,for
R3303 T5297 T5295 nsubj difference,is
R3304 T5298 T5297 amod apparent,difference
R3305 T5299 T5297 prep in,difference
R3306 T5126 T5119 prep in,role
R3307 T5300 T5301 amod absolute,number
R3308 T5301 T5299 pobj number,in
R3309 T5302 T5301 prep of,number
R3310 T5127 T5126 pobj tasks,in
R3311 T5303 T5302 pobj errors,of
R3312 T5304 T5297 acl demonstrated,difference
R3313 T5305 T5304 agent by,demonstrated
R3314 T5128 T5127 acl requiring,tasks
R3315 T5306 T5307 det the,mice
R3316 T5307 T5305 pobj mice,by
R3317 T5308 T5307 amod mutant,mice
R3318 T5129 T5130 amod behavioral,flexibility
R3319 T5309 T5310 punct (,deficit
R3320 T5310 T5297 appos deficit,difference
R3321 T5311 T5310 det the,deficit
R3322 T5130 T5128 dobj flexibility,requiring
R3323 T5312 T5310 amod putative,deficit
R3324 T5313 T5310 compound performance,deficit
R3325 T5314 T5310 punct ),deficit
R3326 T5315 T5316 advmod simply,reflection
R3327 T5316 T5295 attr reflection,is
R3328 T5317 T5316 det a,reflection
R3329 T5132 T5133 amod Perseverative,patterns
R3330 T5318 T5316 prep of,reflection
R3331 T5319 T5320 amod extra,trials
R3332 T5320 T5318 pobj trials,of
R3333 T5321 T5282 punct .,control
R3334 T5133 T5135 nsubj patterns,characterized
R3335 T5323 T5324 advmod Nonetheless,argues
R3336 T5134 T5133 amod behavioral,patterns
R3337 T5136 T5137 det the,mice
R3338 T5325 T5324 punct ", ",argues
R3339 T5326 T5327 det the,inability
R3340 T5137 T5135 dobj mice,characterized
R3341 T5327 T5324 nsubj inability,argues
R3342 T5138 T5137 nmod D2R,mice
R3343 T5328 T5327 prep of,inability
R3344 T5329 T5330 nmod D2R,mice
R3345 T5330 T5328 pobj mice,of
R3346 T5331 T5329 punct -,D2R
R3347 T5139 T5138 punct -,D2R
R3348 T5332 T5329 punct /,D2R
R3349 T5333 T5329 punct -,D2R
R3350 T5140 T5138 punct /,D2R
R3351 T5334 T5335 aux to,disengage
R3352 T5335 T5327 acl disengage,inability
R3353 T5336 T5335 prep from,disengage
R3354 T5141 T5138 punct -,D2R
R3355 T5337 T5338 advmod previously,established
R3356 T5338 T5339 amod established,contingencies
R3357 T5142 T5137 amod relative,mice
R3358 T5339 T5336 pobj contingencies,from
R3359 T5340 T5339 nmod S,contingencies
R3360 T5341 T5340 punct +,S
R3361 T5342 T5340 punct /,S
R3362 T5143 T5142 prep to,relative
R3363 T5343 T5340 appos S,S
R3364 T5344 T5343 punct -,S
R3365 T5144 T5145 nmod D2R,mice
R3366 T5345 T5346 punct (,Fig.
R3367 T5346 T5327 parataxis Fig.,inability
R3368 T5347 T5346 advcl responding,Fig.
R3369 T5145 T5143 pobj mice,to
R3370 T5348 T5347 prep to,responding
R3371 T5349 T5350 det a,stimulus
R3372 T5350 T5348 pobj stimulus,to
R3373 T5146 T5144 punct +,D2R
R3375 T5352 T5346 punct ;,Fig.
R3376 T5353 T5346 nummod 4,Fig.
R3377 T5147 T5144 punct /,D2R
R3378 T5354 T5346 punct ),Fig.
R3379 T5355 T5324 advmod strongly,argues
R3380 T5356 T5357 mark that,modulates
R3381 T5357 T5324 ccomp modulates,argues
R3384 T5148 T5144 punct +,D2R
R3385 T5360 T5359 punct ", ",dopamine
R3386 T5361 T5359 cc and,dopamine
R3387 T5362 T5363 prep in,signaling
R3388 T5149 T5135 prep during,characterized
R3389 T5363 T5359 conj signaling,dopamine
R3390 T5364 T5362 amod particular,in
R3391 T5365 T5366 compound dopamine,D2R
R3392 T5150 T5151 compound reversal,sessions
R3393 T5366 T5367 npadvmod D2R,mediated
R3394 T5151 T5149 pobj sessions,during
R3395 T5367 T5363 amod mediated,signaling
R3396 T5368 T5367 punct -,mediated
R3397 T5369 T5357 punct ", ",modulates
R3398 T5152 T5151 compound learning,sessions
R3399 T5370 T5371 det the,process
R3400 T5371 T5357 dobj process,modulates
R3401 T5372 T5371 prep of,process
R3402 T5153 T5154 punct (,Figure
R3403 T5373 T5372 pcomp alerting,of
R3404 T5374 T5375 det the,subject
R3405 T5154 T5135 parataxis Figure,characterized
R3406 T5155 T5154 nummod 4,Figure
R3407 T5375 T5373 dobj subject,alerting
R3408 T5156 T5154 punct ),Figure
R3409 T5376 T5377 mark that,associated
R3410 T5377 T5373 ccomp associated,alerting
R3411 T5157 T5135 punct ", ",characterized
R3412 T5378 T5379 amod familiar,contingencies
R3413 T5379 T5377 nsubjpass contingencies,associated
R3414 T5380 T5377 auxpass are,associated
R3415 T5158 T5135 conj manifested,characterized
R3416 T5381 T5377 advmod now,associated
R3417 T5382 T5383 amod unexpected,consequences
R3418 T5383 T5377 dep consequences,associated
R3419 T5159 T5158 prep during,manifested
R3420 T5384 T5324 punct .,argues
R3421 T5386 T5387 nsubj Schultz,demonstrated
R3422 T5160 T5161 amod early,trials
R3423 T5388 T5386 cc and,Schultz
R3424 T5161 T5159 pobj trials,during
R3425 T5389 T5386 conj colleagues,Schultz
R3426 T5390 T5387 aux have,demonstrated
R3427 T5391 T5392 mark that,display
R3428 T5162 T5161 compound reversal,trials
R3429 T5163 T5164 punct (,Figure
R3430 T5164 T5159 parataxis Figure,during
R3431 T5392 T5387 ccomp display,demonstrated
R3432 T5393 T5394 compound dopamine,cells
R3433 T5394 T5392 nsubj cells,display
R3434 T5165 T5164 nummod 6,Figure
R3435 T5395 T5396 amod consistent,patterns
R3436 T5396 T5392 dobj patterns,display
R3437 T5397 T5398 amod tonic,firing
R3438 T5166 T5164 punct ),Figure
R3439 T5398 T5396 compound firing,patterns
R3440 T5399 T5392 prep during,display
R3441 T5400 T5399 pobj maintenance,during
R3442 T5167 T5158 cc and,manifested
R3443 T5401 T5400 prep of,maintenance
R3444 T5402 T5403 amod associative,learning
R3445 T5403 T5404 compound learning,tasks
R3446 T5168 T5158 conj persisted,manifested
R3447 T5404 T5401 pobj tasks,of
R3448 T5405 T5406 punct [,33
R3449 T5406 T5387 parataxis 33,demonstrated
R3450 T5169 T5168 prep across,persisted
R3451 T5407 T5406 punct ],33
R3452 T5170 T5171 amod several,sessions
R3453 T5171 T5169 pobj sessions,across
R3454 T5408 T5387 punct .,demonstrated
R3455 T5172 T5173 punct (,Figure
R3456 T5410 T5411 advmod However,occurs
R3457 T5173 T5168 parataxis Figure,persisted
R3458 T5412 T5411 punct ", ",occurs
R3459 T5413 T5414 amod phasic,activity
R3460 T5414 T5411 nsubj activity,occurs
R3461 T5174 T5173 nummod 7,Figure
R3462 T5415 T5414 compound burst,activity
R3463 T5416 T5414 prep of,activity
R3464 T5417 T5418 amod dopaminergic,cells
R3465 T5175 T5173 punct ),Figure
R3466 T5418 T5416 pobj cells,of
R3467 T5176 T5135 punct .,characterized
R3468 T5419 T5420 advmod when,transpire
R3469 T5420 T5411 advcl transpire,occurs
R3470 T5421 T5420 nsubj discrepancies,transpire
R3471 T5178 T5179 det These,findings
R3472 T5422 T5421 prep between,discrepancies
R3473 T5423 T5424 amod predicted,contingencies
R3474 T5424 T5422 pobj contingencies,between
R3475 T5425 T5423 cc and,predicted
R3476 T5179 T5180 nsubj findings,are
R3477 T5426 T5423 conj actual,predicted
R3478 T5427 T5424 compound reinforcement,contingencies
R3479 T5498 T5497 compound dopamine,D2R
R3480 T5428 T5429 punct [,14
R3481 T5429 T5411 parataxis 14,occurs
R3482 T5430 T5429 punct ],14
R3483 T5431 T5411 punct .,occurs
R3484 T5433 T5434 det This,increase
R3485 T5499 T5495 aux might,be
R3486 T5434 T5436 nsubjpass increase,referred
R3487 T5435 T5434 amod robust,increase
R3488 T5500 T5495 prep in,be
R3489 T5437 T5434 prep of,increase
R3490 T5438 T5439 amod dopaminergic,activation
R3491 T5439 T5437 pobj activation,of
R3492 T5501 T5500 pobj fact,in
R3493 T5440 T5439 compound cell,activation
R3494 T5441 T5434 prep in,increase
R3495 T5442 T5441 pobj response,in
R3496 T5502 T5503 det the,point
R3497 T5443 T5442 prep to,response
R3498 T5444 T5445 amod unpredicted,outcomes
R3499 T5445 T5443 pobj outcomes,to
R3500 T5503 T5495 attr point,be
R3501 T5446 T5436 aux has,referred
R3502 T5447 T5436 auxpass been,referred
R3503 T5448 T5436 prep to,referred
R3504 T5504 T5503 amod focal,point
R3505 T5449 T5436 prep as,referred
R3506 T5450 T5451 det an,signal
R3507 T5505 T5503 prep of,point
R3508 T5451 T5449 pobj signal,as
R3509 T5452 T5451 punct """",signal
R3510 T5453 T5451 nmod error,signal
R3511 T5506 T5507 det this,cascade
R3512 T5454 T5451 punct """",signal
R3513 T5455 T5456 punct [,14
R3514 T5456 T5436 parataxis 14,referred
R3515 T5507 T5505 pobj cascade,of
R3516 T5457 T5456 punct ],14
R3517 T5458 T5436 punct .,referred
R3518 T5508 T5509 npadvmod error,signaling
R3519 T5460 T5461 prep To,identified
R3520 T5509 T5507 amod signaling,cascade
R3521 T5462 T5460 pobj date,To
R3522 T5463 T5461 punct ", ",identified
R3523 T5464 T5465 det the,basis
R3524 T5510 T5509 punct -,signaling
R3525 T5465 T5461 nsubjpass basis,identified
R3526 T5466 T5465 amod molecular,basis
R3527 T5467 T5465 prep of,basis
R3528 T5511 T5478 punct .,suggests
R3529 T5468 T5469 det this,signal
R3530 T5469 T5467 pobj signal,of
R3531 T5513 T5514 amod Electrophysiological,data
R3532 T5470 T5469 compound error,signal
R3533 T5471 T5461 aux has,identified
R3534 T5472 T5461 neg not,identified
R3535 T5473 T5461 auxpass been,identified
R3536 T5474 T5461 punct .,identified
R3537 T5476 T5477 det The,inability
R3538 T5514 T5515 nsubj data,support
R3539 T5477 T5478 nsubj inability,suggests
R3540 T5479 T5477 prep of,inability
R3541 T5516 T5515 advmod further,support
R3542 T5480 T5481 det the,mice
R3543 T5481 T5479 pobj mice,of
R3544 T5482 T5481 nmod D2R,mice
R3545 T5483 T5482 punct -,D2R
R3546 T5517 T5518 det the,hypothesis
R3547 T5484 T5482 punct /,D2R
R3548 T5485 T5482 punct -,D2R
R3549 T5518 T5515 dobj hypothesis,support
R3550 T5486 T5487 aux to,desist
R3551 T5487 T5477 acl desist,inability
R3552 T5488 T5487 xcomp responding,desist
R3553 T5519 T5520 mark that,tunes
R3554 T5489 T5488 prep to,responding
R3555 T5490 T5491 det a,stimulus
R3556 T5491 T5489 pobj stimulus,to
R3557 T5520 T5518 acl tunes,hypothesis
R3558 T5492 T5493 advmod previously,reinforced
R3559 T5493 T5491 amod reinforced,stimulus
R3560 T5494 T5495 mark that,be
R3561 T5521 T5520 nsubj signaling,tunes
R3562 T5522 T5521 acl mediated,signaling
R3563 T5495 T5478 ccomp be,suggests
R3564 T5523 T5522 agent by,mediated
R3565 T5496 T5497 det the,D2R
R3566 T5497 T5495 nsubj D2R,be
R3567 T5524 T5525 compound dopamine,D2Rs
R3568 T5525 T5523 pobj D2Rs,by
R3569 T5526 T5527 npadvmod D1R,mediated
R3570 T5527 T5529 amod mediated,output
R3571 T5604 T5605 nsubj Carlsson,speculated
R3572 T5528 T5527 punct -,mediated
R3573 T5606 T5604 cc and,Carlsson
R3574 T5607 T5604 conj colleagues,Carlsson
R3575 T5529 T5520 dobj output,tunes
R3576 T5608 T5609 punct [,35
R3577 T5609 T5607 parataxis 35,colleagues
R3578 T5610 T5609 punct ],35
R3579 T5530 T5529 amod mesocorticolimbic,output
R3580 T5611 T5605 aux have,speculated
R3581 T5612 T5613 mark that,serves
R3582 T5613 T5605 ccomp serves,speculated
R3583 T5531 T5515 punct .,support
R3584 T5614 T5615 compound dopamine,D2R
R3585 T5615 T5616 compound D2R,stimulation
R3586 T5616 T5613 nsubj stimulation,serves
R3587 T5617 T5616 prep in,stimulation
R3588 T5618 T5619 det the,striatum
R3589 T5619 T5617 pobj striatum,in
R3590 T5533 T5534 nsubj Calabresi,demonstrated
R3591 T5620 T5621 aux to,brake
R3592 T5621 T5613 xcomp brake,serves
R3593 T5622 T5621 punct """",brake
R3594 T5623 T5621 punct """",brake
R3595 T5535 T5536 advmod et,al.
R3596 T5624 T5621 cc or,brake
R3597 T5625 T5621 conj diminish,brake
R3598 T5626 T5627 amod excitatory,signaling
R3599 T5627 T5625 dobj signaling,diminish
R3600 T5536 T5533 advmod al.,Calabresi
R3601 T5628 T5627 amod corticostriatal,signaling
R3602 T5629 T5627 cc and,signaling
R3603 T5630 T5627 conj plasticity,signaling
R3604 T5537 T5538 punct [,34
R3605 T5631 T5605 punct .,speculated
R3606 T5538 T5533 parataxis 34,Calabresi
R3607 T5633 T5634 advmod Indeed,associated
R3608 T5635 T5634 punct ", ",associated
R3609 T5539 T5538 punct ],34
R3610 T5636 T5637 amod perseverative,behavior
R3611 T5637 T5634 nsubjpass behavior,associated
R3612 T5638 T5634 auxpass is,associated
R3613 T5540 T5541 mark that,associated
R3614 T5639 T5634 prep with,associated
R3615 T5640 T5641 amod over,activity
R3616 T5541 T5534 ccomp associated,demonstrated
R3617 T5641 T5639 pobj activity,with
R3618 T5642 T5641 prep of,activity
R3619 T5542 T5543 amod tetanic,stimulation
R3620 T5643 T5644 det the,striatum
R3621 T5644 T5642 pobj striatum,of
R3622 T5645 T5644 amod dorsal,striatum
R3623 T5543 T5541 nsubjpass stimulation,associated
R3624 T5646 T5641 prep in,activity
R3625 T5647 T5646 pobj rodents,in
R3626 T5544 T5543 prep of,stimulation
R3627 T5648 T5649 punct [,36
R3628 T5649 T5641 parataxis 36,activity
R3629 T5650 T5649 punct ],36
R3630 T5545 T5546 amod dorsal,slices
R3631 T5651 T5641 cc and,activity
R3632 T5652 T5653 amod over,activity
R3633 T5653 T5641 conj activity,activity
R3634 T5546 T5544 pobj slices,of
R3635 T5654 T5653 prep of,activity
R3636 T5655 T5656 det the,caudate
R3637 T5547 T5546 compound striatum,slices
R3638 T5656 T5654 pobj caudate,of
R3639 T5657 T5653 prep in,activity
R3640 T5658 T5657 pobj patients,in
R3641 T5659 T5658 prep with,patients
R3642 T5660 T5659 pobj ADHD,with
R3643 T5661 T5662 punct [,37
R3644 T5548 T5546 acl prepared,slices
R3645 T5662 T5653 parataxis 37,activity
R3646 T5663 T5662 punct ],37
R3647 T5664 T5634 cc and,associated
R3648 T5549 T5548 prep from,prepared
R3649 T5665 T5666 det a,correlation
R3650 T5666 T5669 nsubjpass correlation,reported
R3651 T5667 T5666 amod strong,correlation
R3652 T5550 T5551 nmod D2R,mice
R3653 T5668 T5666 amod inverse,correlation
R3654 T5551 T5549 pobj mice,from
R3655 T5552 T5550 punct -,D2R
R3658 T5553 T5550 punct /,D2R
R3662 T5554 T5550 punct -,D2R
R3665 T5555 T5541 auxpass is,associated
R3668 T5556 T5541 prep with,associated
R3669 T5678 T5679 punct [,22
R3670 T5679 T5669 parataxis 22,reported
R3671 T5557 T5558 amod enhanced,EPSP
R3672 T5680 T5679 punct ],22
R3673 T5681 T5669 punct .,reported
R3674 T5558 T5556 pobj EPSP,with
R3675 T5683 T5684 advmod Importantly,indicate
R3676 T5559 T5558 cc and,EPSP
R3677 T5685 T5684 punct ", ",indicate
R3678 T5686 T5687 poss our,data
R3679 T5560 T5561 prep as,efficacy
R3680 T5687 T5684 nsubj data,indicate
R3681 T5688 T5689 mark that,are
R3682 T5561 T5558 conj efficacy,EPSP
R3683 T5689 T5684 ccomp are,indicate
R3684 T5690 T5691 det the,performances
R3685 T5691 T5689 nsubj performances,are
R3686 T5562 T5563 det a,result
R3687 T5692 T5691 amod poor,performances
R3688 T5693 T5691 acl displayed,performances
R3689 T5694 T5693 agent by,displayed
R3690 T5695 T5696 det the,mice
R3691 T5696 T5694 pobj mice,by
R3692 T5563 T5560 pobj result,as
R3693 T5697 T5696 nmod D2R,mice
R3694 T5698 T5697 punct -,D2R
R3695 T5564 T5561 amod increased,efficacy
R3696 T5699 T5697 punct /,D2R
R3697 T5700 T5697 punct -,D2R
R3698 T5701 T5689 attr manifestations,are
R3699 T5565 T5561 amod striatal,efficacy
R3700 T5702 T5701 prep of,manifestations
R3701 T5703 T5704 compound reversal,learning
R3702 T5704 T5705 compound learning,deficits
R3703 T5566 T5561 amod synaptic,efficacy
R3704 T5705 T5702 pobj deficits,of
R3705 T5706 T5701 cc and,manifestations
R3706 T5707 T5706 neg not,and
R3707 T5567 T5534 punct .,demonstrated
R3708 T5708 T5709 amod gross,impairments
R3709 T5709 T5701 conj impairments,manifestations
R3710 T5569 T5570 prep In,resulted
R3711 T5571 T5569 pobj contrast,In
R3714 T5572 T5570 punct ", ",resulted
R3715 T5712 T5710 conj sensory,motivational
R3717 T5573 T5570 nsubj stimulation,resulted
R3718 T5715 T5716 nsubj We,argue
R3719 T5574 T5573 prep of,stimulation
R3720 T5717 T5716 advmod therefore,argue
R3721 T5718 T5719 mark that,participate
R3722 T5719 T5716 ccomp participate,argue
R3723 T5575 T5576 amod dorsal,slices
R3724 T5720 T5719 nsubj D2Rs,participate
R3725 T5721 T5719 prep in,participate
R3726 T5576 T5574 pobj slices,of
R3727 T5722 T5721 pcomp signaling,in
R3728 T5723 T5722 cc or,signaling
R3729 T5724 T5722 conj alerting,signaling
R3730 T5577 T5576 compound striatum,slices
R3731 T5725 T5726 det the,organism
R3732 T5726 T5724 dobj organism,alerting
R3733 T5727 T5726 prep of,organism
R3734 T5578 T5573 prep from,stimulation
R3735 T5728 T5729 compound learning,contingency
R3736 T5729 T5730 compound contingency,changes
R3737 T5730 T5727 pobj changes,of
R3738 T5579 T5580 amod wild,type
R3739 T5731 T5724 prep during,alerting
R3740 T5732 T5733 compound reversal,learning
R3741 T5580 T5582 compound type,mice
R3742 T5733 T5731 pobj learning,during
R3743 T5734 T5719 cc and,participate
R3744 T5735 T5719 conj sculpt,participate
R3745 T5736 T5737 amod ongoing,behavior
R3746 T5737 T5735 dobj behavior,sculpt
R3747 T5738 T5739 npadvmod goal,directed
R3748 T5581 T5580 punct -,type
R3749 T5739 T5737 amod directed,behavior
R3750 T5740 T5739 punct -,directed
R3751 T5741 T5716 punct .,argue
R3752 T5582 T5578 pobj mice,from
R3753 T5583 T5570 prep in,resulted
R3754 T5584 T5585 compound IPSP,activity
R3755 T5585 T5583 pobj activity,in
R3756 T5586 T5585 punct ", ",activity
R3757 T5587 T5588 amod long,term
R3758 T5588 T5590 compound term,depression
R3759 T5589 T5588 punct -,term
R3760 T5590 T5585 conj depression,activity
R3761 T5591 T5590 punct ", ",depression
R3762 T5592 T5590 cc and,depression
R3763 T5593 T5594 amod decreased,activity
R3764 T5594 T5590 conj activity,depression
R3765 T5595 T5594 amod neuronal,activity
R3766 T5596 T5594 prep of,activity
R3767 T5597 T5598 amod striatal,efferents
R3768 T5598 T5596 pobj efferents,of
R3769 T5599 T5600 punct [,34
R3770 T5600 T5570 parataxis 34,resulted
R3771 T5601 T5600 punct ],34
R3772 T5602 T5570 punct .,resulted
R3383 T5359 T5357 nsubj dopamine,modulates
R3712 T5710 T5709 amod motivational,impairments
R3713 T5711 T5710 cc or,motivational
R3716 T5713 T5684 punct .,indicate
R3024 T4984 T4985 det the,mice
R3374 T5351 T5350 amod discriminative,stimulus
R3382 T5358 T5359 amod mesolimbic,dopamine
R3656 T5669 T5634 conj reported,associated
R3657 T5670 T5666 prep of,correlation
R3659 T5671 T5672 compound D2R,binding
R3660 T5672 T5670 pobj binding,of
R3661 T5673 T5666 prep with,correlation
R3663 T5674 T5675 amod compulsive,behavior
R3664 T5675 T5673 pobj behavior,with
R3666 T5676 T5669 aux has,reported
R3667 T5677 T5669 auxpass been,reported

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3736 69-77 CHEBI:18243 denotes dopamine
T3737 69-89 PR_EXT:000001177 denotes dopamine D2 receptor
T3738 81-89 GO_EXT:0004872 denotes receptor
T3739 99-108 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3740 134-145 _FRAGMENT denotes associative
T3741 159-167 GO:0008306 denotes learning
T3742 169-172 PR_EXT:000001177 denotes D2R
T3743 172-173 SO_EXT:sequence_nullness_or_absence denotes -
T3744 174-175 SO_EXT:sequence_nullness_or_absence denotes -
T3745 176-180 NCBITaxon:10088 denotes mice
T3746 220-228 GO:0007612 denotes learning
T3747 243-250 GO:0007631 denotes consume
T3748 251-255 CHEBI_EXT:33290 denotes food
T3749 287-305 GO:0007626 denotes locomotor behavior
T3750 396-400 CHEBI_EXT:33290 denotes food
T3751 458-461 PR_EXT:000001177 denotes D2R
T3752 461-462 SO_EXT:sequence_nullness_or_absence denotes -
T3753 463-464 SO_EXT:sequence_nullness_or_absence denotes -
T3754 465-469 NCBITaxon:10088 denotes mice
T3755 576-579 PR_EXT:000001177 denotes D2R
T3756 589-598 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3757 618-626 CL:0000540 denotes neuronal
T3758 720-723 PR_EXT:000001177 denotes D2R
T3759 723-724 SO_EXT:sequence_nullness_or_absence denotes -
T3760 725-726 SO_EXT:sequence_nullness_or_absence denotes -
T3761 727-731 NCBITaxon:10088 denotes mice
T3762 811-819 CHEBI:18243 denotes dopamine
T3763 811-829 GO:0007212 denotes dopamine signaling
T3764 843-851 CHEBI:18243 denotes dopamine
T3765 843-856 PR_EXT:000001177 denotes dopamine D2Rs
T3766 893-901 GO:0007612 denotes learning
T3767 912-916 NCBITaxon:10088 denotes Mice
T3768 940-948 CHEBI:18243 denotes dopamine
T3769 940-952 PR_EXT:000001177 denotes dopamine D2R
T3770 962-971 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3771 1034-1038 CHEBI_EXT:33290 denotes food
T3772 1060-1067 GO:0007612 denotes learned
T3773 1079-1083 CHEBI_EXT:33290 denotes food
T3774 1195-1199 NCBITaxon:10114 denotes rats
T3775 1221-1224 PR_EXT:000001177 denotes D2R
T3776 1225-1236 CHEBI_GO_EXT:antagonist denotes antagonists
T3777 1275-1281 CHEBI:78741 denotes 6-OHDA
T3778 1303-1314 _FRAGMENT denotes associative
T3779 1327-1335 GO:0008306 denotes learning
T3780 1422-1430 CHEBI:18243 denotes dopamine
T3781 1455-1459 PR_EXT:000001177 denotes D2Rs
T3782 1469-1480 GO_EXT:behavioral_conditioning denotes conditioned
T3783 1510-1514 CHEBI_EXT:33290 denotes food
T3784 1567-1570 PR_EXT:000001177 denotes D2R
T3785 1570-1571 SO_EXT:sequence_nullness_or_absence denotes -
T3786 1572-1573 SO_EXT:sequence_nullness_or_absence denotes -
T3787 1574-1578 NCBITaxon:10088 denotes mice
T3788 1628-1632 PR_EXT:000001177 denotes D2Rs
T3789 1694-1714 GO:0008306 denotes associative learning
T3790 1804-1824 GO:0008306 denotes associative learning
T3791 1841-1849 CHEBI:18243 denotes dopamine
T3792 1841-1854 PR_EXT:000001175 denotes dopamine D1Rs
T3793 1889-1897 CHEBI:18243 denotes dopamine
T3794 1889-1902 PR_EXT:000001175 denotes dopamine D1Rs
T3795 1908-1916 CHEBI:18243 denotes dopamine
T3796 1926-1934 GO:0007612 denotes learning
T3797 1939-1943 PR_EXT:000001177 denotes D2Rs
T3798 1949-1954 GO_EXT:biological_movement_or_translocation_process denotes motor
T3799 1963-1972 GO_PATO_EXT:biological_behavior denotes behaviors
T3800 2050-2061 PR_EXT:000001177 denotes dopamine D2
T3801 2050-2060 _FRAGMENT denotes dopamine D
T3802 2062-2063 PR_EXT:000001178 denotes 3
T3803 2050-2058 _FRAGMENT denotes dopamine
T3804 2064-2074 CHEBI_EXT:48561 denotes antagonist
T3805 2064-2074 CHEBI_GO_EXT:antagonist denotes antagonist
T3806 2121-2125 CHEBI_EXT:33290 denotes food
T3807 2136-2156 GO:0008306 denotes associative learning
T3808 2201-2212 CHEBI_GO_EXT:antagonist denotes antagonists
T3809 2229-2237 GO:0007612 denotes learning
T3810 2271-2274 PR_EXT:000001175 denotes D1R
T3811 2278-2281 PR_EXT:000001177 denotes D2R
T3812 2410-2421 CHEBI_GO_EXT:antagonist denotes antagonists
T3813 2488-2491 PR_EXT:000001177 denotes D2R
T3814 2501-2510 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3815 2570-2573 PR_EXT:000001177 denotes D2R
T3816 2583-2592 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3817 2596-2607 _FRAGMENT denotes associative
T3818 2621-2629 GO:0008306 denotes learning
T3819 2713-2716 PR_EXT:000001177 denotes D2R
T3820 2717-2728 CHEBI_GO_EXT:antagonist denotes antagonists
T3821 2732-2742 GO:0040011 denotes locomotion
T3822 2747-2755 GO:0007612 denotes learning
T3823 2824-2827 PR_EXT:000001177 denotes D2R
T3824 2837-2846 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3825 2865-2870 GO_EXT:biological_movement_or_translocation_process denotes motor
T3826 2885-2893 GO:0007612 denotes learning
T3827 2978-2983 CHEBI_EXT:23888 denotes drugs
T3828 3056-3064 CHEBI:18243 denotes dopamine
T3829 3056-3069 PR_EXT:000001177 denotes dopamine D2Rs
T3830 3149-3153 PR_EXT:000001177 denotes D2Rs
T3831 3157-3177 GO:0008306 denotes associative learning
T3832 3224-3233 GO:0040011 denotes locomotor
T3833 3316-3321 GO_EXT:biological_movement_or_translocation_process denotes motor
T3834 3322-3330 GO_PATO_EXT:biological_behavior denotes behavior
T3835 3391-3399 GO:0007612 denotes learning
T3836 3470-3474 PR_EXT:000001177 denotes D2Rs
T3837 3478-3498 GO:0008306 denotes associative learning
T3838 3519-3524 GO_EXT:biological_movement_or_translocation_process denotes motor
T3839 3525-3533 GO_PATO_EXT:biological_behavior denotes behavior
T3840 3650-3653 PR_EXT:000001177 denotes D2R
T3841 3654-3665 CHEBI_GO_EXT:antagonist denotes antagonists
T3842 3669-3676 NCBITaxon:9989 denotes rodents
T3843 3706-3716 GO_PATO_EXT:biological_behavior denotes behavioral
T3844 3806-3810 PR_EXT:000001177 denotes D2Rs
T3845 3861-3881 GO:0008306 denotes associative learning
T3846 3885-3892 NCBITaxon:9989 denotes rodents
T3847 3933-3936 PR_EXT:000001177 denotes D2R
T3848 3937-3948 CHEBI_GO_EXT:antagonist denotes antagonists
T3849 3966-3976 GO_PATO_EXT:biological_behavior denotes behavioral
T3850 3996-4001 GO_EXT:biological_movement_or_translocation_process denotes motor
T3851 4104-4112 CHEBI:18243 denotes dopamine
T3852 4104-4121 GO_EXT:0004952 denotes dopamine receptor
T3853 4204-4215 CHEBI_GO_EXT:antagonist denotes antagonists
T3854 4225-4229 PR_EXT:000001177 denotes D2Rs
T3855 4231-4235 PR_EXT:000001178 denotes D3Rs
T3856 4241-4245 PR_EXT:000001179 denotes D4Rs
T3857 4352-4356 NCBITaxon:10088 denotes mice
T3858 4372-4383 SO_EXT:0000704 denotes genetically
T3859 4384-4391 SO_EXT:sequence_alteration_process denotes altered
T3860 4442-4449 SO_EXT:0001023 denotes alleles
T3861 4466-4474 GO_EXT:0004872 denotes receptor
T3862 4580-4585 NCBITaxon:10088 denotes mouse
T3863 4709-4716 NCBITaxon:33208 denotes animals
T3864 4763-4781 GO:0007626 denotes locomotor behavior
T3865 4804-4807 PR_EXT:000001177 denotes D2R
T3866 4807-4808 SO_EXT:sequence_nullness_or_absence denotes -
T3867 4809-4810 SO_EXT:sequence_nullness_or_absence denotes -
T3868 4815-4818 PR_EXT:000001177 denotes D2R
T3869 4818-4819 SO_EXT:normal_or_wild_type_or_present denotes +
T3870 4820-4821 SO_EXT:normal_or_wild_type_or_present denotes +
T3871 4822-4826 NCBITaxon:10088 denotes mice
T3872 4884-4887 PR_EXT:000001177 denotes D2R
T3873 4897-4906 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3874 4910-4930 GO:0008306 denotes associative learning
T3875 5023-5026 PR_EXT:000001177 denotes D2R
T3876 5027-5038 CHEBI_GO_EXT:antagonist denotes antagonists
T3877 5102-5109 SO_EXT:0000704 denotes genetic
T3878 5110-5122 SO_EXT:sequence_alteration_process denotes manipulation
T3879 5130-5134 PR_EXT:000001177 denotes drd2
T3880 5159-5168 GO:0007608 denotes olfactory
T3881 5187-5190 PR_EXT:000001177 denotes D2R
T3882 5190-5191 SO_EXT:sequence_nullness_or_absence denotes -
T3883 5192-5193 SO_EXT:sequence_nullness_or_absence denotes -
T3884 5194-5198 NCBITaxon:10088 denotes mice
T3885 5253-5256 PR_EXT:000001177 denotes D2R
T3886 5256-5257 SO_EXT:sequence_nullness_or_absence denotes -
T3887 5258-5259 SO_EXT:sequence_nullness_or_absence denotes -
T3888 5260-5264 NCBITaxon:10088 denotes mice
T3889 5269-5274 GO:0007612 denotes learn
T3890 5291-5295 CHEBI_EXT:33290 denotes food
T3891 5335-5342 GO:0007612 denotes learned
T3892 5427-5435 CHEBI:18243 denotes dopamine
T3893 5427-5441 PR_EXT:000001177 denotes dopamine D2R's
T3894 5457-5470 CHEBI_EXT:glutamate denotes glutamatergic
T3895 5471-5479 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T3896 5480-5485 GO:0030424 denotes axons
T3897 5489-5498 GO:0007608 denotes olfactory
T3898 5489-5505 UBERON:0001579 denotes olfactory nerves
T3899 5542-5551 GO:0007608 denotes olfactory
T3900 5542-5557 UBERON:0001579 denotes olfactory nerve
T3901 5565-5580 _FRAGMENT denotes mitral cells of
T3902 5585-5599 CL:1001502 denotes olfactory bulb
T3903 5572-5577 CL_GO_EXT:cell denotes cells
T3904 5585-5594 GO:0007608 denotes olfactory
T3905 5585-5599 UBERON:0002264 denotes olfactory bulb
T3906 5696-5700 PR_EXT:000001177 denotes D2Rs
T3907 5708-5717 GO:0007608 denotes olfactory
T3908 5708-5722 UBERON:0002264 denotes olfactory bulb
T3909 5756-5765 GO:0007608 denotes olfactory
T3910 5808-5817 GO:0046959 denotes habituate
T3911 5828-5837 GO:0007608 denotes olfactory
T3912 5828-5843 UBERON:0001579 denotes olfactory nerve
T3913 5910-5918 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes chemical
T3914 5953-5956 PR_EXT:000001177 denotes D2R
T3915 5956-5957 SO_EXT:sequence_nullness_or_absence denotes -
T3916 5958-5959 SO_EXT:sequence_nullness_or_absence denotes -
T3917 5960-5964 NCBITaxon:10088 denotes mice
T3918 5981-5989 GO:0007612 denotes learning
T3919 6024-6032 CHEBI:18243 denotes dopamine
T3920 6024-6036 PR_EXT:000001177 denotes dopamine D2R
T3921 6046-6055 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3922 6075-6085 GO_PATO_EXT:biological_behavior denotes behavioral
T3923 6112-6122 GO_PATO_EXT:biological_behavior denotes behavioral
T3924 6150-6153 PR_EXT:000001177 denotes D2R
T3925 6153-6154 SO_EXT:sequence_nullness_or_absence denotes -
T3926 6155-6156 SO_EXT:sequence_nullness_or_absence denotes -
T3927 6157-6161 NCBITaxon:10088 denotes mice
T3928 6174-6177 PR_EXT:000001177 denotes D2R
T3929 6177-6178 SO_EXT:normal_or_wild_type_or_present denotes +
T3930 6179-6180 SO_EXT:normal_or_wild_type_or_present denotes +
T3931 6181-6185 NCBITaxon:10088 denotes mice
T3932 6202-6210 GO:0007612 denotes learning
T3933 6372-6375 PR_EXT:000001177 denotes D2R
T3934 6375-6376 SO_EXT:sequence_nullness_or_absence denotes -
T3935 6377-6378 SO_EXT:sequence_nullness_or_absence denotes -
T3936 6379-6383 NCBITaxon:10088 denotes mice
T3937 6384-6391 GO_EXT:reaction_or_response denotes respond
T3938 6395-6399 CHEBI_EXT:33290 denotes food
T3939 6489-6492 PR_EXT:000001175 denotes D1R
T3940 6502-6510 GO_PATO_EXT:biological_behavior denotes behavior
T3941 6524-6527 PR_EXT:000001177 denotes D2R
T3942 6527-6528 SO_EXT:normal_or_wild_type_or_present denotes +
T3943 6529-6530 SO_EXT:normal_or_wild_type_or_present denotes +
T3944 6531-6535 NCBITaxon:10088 denotes mice
T3945 6593-6601 CHEBI:18243 denotes dopamine
T3946 6593-6606 PR_EXT:000001175 denotes dopamine D1Rs
T3954 7131-7135 NCBITaxon:10088 denotes mice
T3955 7198-7208 GO_EXT:reaction_or_response denotes responding
T3956 7279-7287 CHEBI:18243 denotes dopamine
T3957 7307-7315 CHEBI:18243 denotes dopamine
T3958 7307-7319 PR_EXT:000001177 denotes dopamine D2R
T3959 7329-7338 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3960 7340-7349 GO:0065007 denotes modulates
T3961 7504-7512 CHEBI:18243 denotes dopamine
T3962 7504-7518 CL:0000700 denotes dopamine cells
T3963 7513-7518 CL_GO_EXT:cell denotes cells
T3964 7582-7602 GO:0008306 denotes associative learning
T3965 7649-7661 CHEBI:18243 denotes dopaminergic
T3966 7649-7667 CL:0000700 denotes dopaminergic cells
T3967 7662-7667 CL_GO_EXT:cell denotes cells
T3968 7791-7803 CHEBI:18243 denotes dopaminergic
T3969 7791-7808 CL:0000700 denotes dopaminergic cell
T3970 7804-7808 CL_GO_EXT:cell denotes cell
T3971 7804-7819 GO:0001775 denotes cell activation
T3972 7823-7831 GO_EXT:reaction_or_response denotes response
T3973 7917-7926 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T3974 8000-8003 PR_EXT:000001177 denotes D2R
T3975 8003-8004 SO_EXT:sequence_nullness_or_absence denotes -
T3976 8005-8006 SO_EXT:sequence_nullness_or_absence denotes -
T3977 8007-8011 NCBITaxon:10088 denotes mice
T3978 8022-8032 GO_EXT:reaction_or_response denotes responding
T3979 8087-8095 CHEBI:18243 denotes dopamine
T3980 8087-8099 PR_EXT:000001177 denotes dopamine D2R
T3981 8147-8164 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling cascade
T3982 8228-8237 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3983 8250-8258 CHEBI:18243 denotes dopamine
T3984 8250-8263 PR_EXT:000001177 denotes dopamine D2Rs
T3985 8270-8273 PR_EXT:000001175 denotes D1R
T3986 8372-8387 UBERON:0005382 denotes dorsal striatum
T3987 8409-8412 PR_EXT:000001177 denotes D2R
T3988 8412-8413 SO_EXT:sequence_nullness_or_absence denotes -
T3989 8414-8415 SO_EXT:sequence_nullness_or_absence denotes -
T3990 8416-8420 NCBITaxon:10088 denotes mice
T3991 8480-8488 UBERON:0002435 denotes striatal
T3992 8489-8497 GO:0045202 denotes synaptic
T3993 8536-8551 UBERON:0005382 denotes dorsal striatum
T3994 8564-8573 SO_EXT:wild_type_entity_or_quality denotes wild-type
T3995 8574-8578 NCBITaxon:10088 denotes mice
T3996 8642-8650 CL:0000540 denotes neuronal
T3997 8663-8671 UBERON:0002435 denotes striatal
T3998 8672-8681 UBERON:0006798 denotes efferents
T3999 8738-8746 CHEBI:18243 denotes dopamine
T4000 8738-8750 PR_EXT:000001177 denotes dopamine D2R
T4001 8770-8778 UBERON:0002435 denotes striatum
T4002 8836-8845 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T4003 8884-8892 GO_PATO_EXT:biological_behavior denotes behavior
T4004 8933-8948 UBERON:0005382 denotes dorsal striatum
T4005 8952-8959 NCBITaxon:9989 denotes rodents
T4006 8990-8997 UBERON:0001873 denotes caudate
T4007 9061-9064 PR_EXT:000001177 denotes D2R
T4008 9065-9072 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T4009 9089-9097 GO_PATO_EXT:biological_behavior denotes behavior
T4010 9197-9200 PR_EXT:000001177 denotes D2R
T4011 9200-9201 SO_EXT:sequence_nullness_or_absence denotes -
T4012 9202-9203 SO_EXT:sequence_nullness_or_absence denotes -
T4013 9204-9208 NCBITaxon:10088 denotes mice
T4014 9240-9248 GO:0007612 denotes learning
T4015 9288-9295 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T4016 9333-9337 PR_EXT:000001177 denotes D2Rs
T4017 9353-9362 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T4018 9379-9387 NCBITaxon:1 denotes organism
T4019 9391-9399 GO:0007612 denotes learning
T4020 9436-9444 GO:0007612 denotes learning
T4021 9469-9477 GO_EXT:biological_direction_or_guidance denotes directed
T4022 9478-9486 GO_PATO_EXT:biological_behavior denotes behavior
T3947 6614-6618 NCBITaxon:10088 denotes mice
T3948 6823-6831 GO:0007612 denotes learning
T3949 7007-7013 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3950 7014-7018 NCBITaxon:10088 denotes mice
T3951 7124-7127 PR_EXT:000001177 denotes D2R
T3952 7127-7128 SO_EXT:sequence_nullness_or_absence denotes -
T3953 7129-7130 SO_EXT:sequence_nullness_or_absence denotes -
R2139 T3741 T3740 _lexicallyChainedTo learning,associative
R2140 T3779 T3778 _lexicallyChainedTo learning,associative
R2141 T3802 T3801 _lexicallyChainedTo 3,dopamine D
R2142 T3804 T3803 _lexicallyChainedTo antagonist,dopamine
R2143 T3818 T3817 _lexicallyChainedTo learning,associative
R2144 T3902 T3901 _lexicallyChainedTo olfactory bulb,mitral cells of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3544 69-77 CHEBI:18243 denotes dopamine
T3545 69-89 PR:000001177 denotes dopamine D2 receptor
T3546 134-145 _FRAGMENT denotes associative
T3547 159-167 GO:0008306 denotes learning
T3548 169-172 PR:000001177 denotes D2R
T3549 176-180 NCBITaxon:10088 denotes mice
T3550 220-228 GO:0007612 denotes learning
T3551 243-250 GO:0007631 denotes consume
T3552 251-255 CHEBI:33290 denotes food
T3553 287-305 GO:0007626 denotes locomotor behavior
T3554 396-400 CHEBI:33290 denotes food
T3555 458-461 PR:000001177 denotes D2R
T3556 465-469 NCBITaxon:10088 denotes mice
T3557 576-579 PR:000001177 denotes D2R
T3558 618-626 CL:0000540 denotes neuronal
T3559 720-723 PR:000001177 denotes D2R
T3560 727-731 NCBITaxon:10088 denotes mice
T3561 811-819 CHEBI:18243 denotes dopamine
T3562 811-829 GO:0007212 denotes dopamine signaling
T3563 843-851 CHEBI:18243 denotes dopamine
T3564 843-856 PR:000001177 denotes dopamine D2Rs
T3565 893-901 GO:0007612 denotes learning
T3566 912-916 NCBITaxon:10088 denotes Mice
T3567 940-948 CHEBI:18243 denotes dopamine
T3568 940-952 PR:000001177 denotes dopamine D2R
T3569 1034-1038 CHEBI:33290 denotes food
T3570 1060-1067 GO:0007612 denotes learned
T3571 1079-1083 CHEBI:33290 denotes food
T3572 1195-1199 NCBITaxon:10114 denotes rats
T3573 1221-1224 PR:000001177 denotes D2R
T3574 1275-1281 CHEBI:78741 denotes 6-OHDA
T3575 1303-1314 _FRAGMENT denotes associative
T3576 1327-1335 GO:0008306 denotes learning
T3577 1422-1430 CHEBI:18243 denotes dopamine
T3578 1455-1459 PR:000001177 denotes D2Rs
T3579 1510-1514 CHEBI:33290 denotes food
T3580 1567-1570 PR:000001177 denotes D2R
T3581 1574-1578 NCBITaxon:10088 denotes mice
T3582 1628-1632 PR:000001177 denotes D2Rs
T3583 1694-1714 GO:0008306 denotes associative learning
T3584 1804-1824 GO:0008306 denotes associative learning
T3585 1841-1849 CHEBI:18243 denotes dopamine
T3586 1841-1854 PR:000001175 denotes dopamine D1Rs
T3587 1889-1897 CHEBI:18243 denotes dopamine
T3588 1889-1902 PR:000001175 denotes dopamine D1Rs
T3589 1908-1916 CHEBI:18243 denotes dopamine
T3590 1926-1934 GO:0007612 denotes learning
T3591 1939-1943 PR:000001177 denotes D2Rs
T3592 2050-2061 PR:000001177 denotes dopamine D2
T3593 2050-2060 _FRAGMENT denotes dopamine D
T3594 2062-2063 PR:000001178 denotes 3
T3595 2050-2058 _FRAGMENT denotes dopamine
T3596 2064-2074 CHEBI:48561 denotes antagonist
T3597 2121-2125 CHEBI:33290 denotes food
T3598 2136-2156 GO:0008306 denotes associative learning
T3599 2229-2237 GO:0007612 denotes learning
T3600 2271-2274 PR:000001175 denotes D1R
T3601 2278-2281 PR:000001177 denotes D2R
T3602 2488-2491 PR:000001177 denotes D2R
T3603 2570-2573 PR:000001177 denotes D2R
T3604 2596-2607 _FRAGMENT denotes associative
T3605 2621-2629 GO:0008306 denotes learning
T3606 2713-2716 PR:000001177 denotes D2R
T3607 2732-2742 GO:0040011 denotes locomotion
T3608 2747-2755 GO:0007612 denotes learning
T3609 2824-2827 PR:000001177 denotes D2R
T3610 2885-2893 GO:0007612 denotes learning
T3611 2978-2983 CHEBI:23888 denotes drugs
T3612 3056-3064 CHEBI:18243 denotes dopamine
T3613 3056-3069 PR:000001177 denotes dopamine D2Rs
T3614 3149-3153 PR:000001177 denotes D2Rs
T3615 3157-3177 GO:0008306 denotes associative learning
T3616 3224-3233 GO:0040011 denotes locomotor
T3617 3391-3399 GO:0007612 denotes learning
T3618 3470-3474 PR:000001177 denotes D2Rs
T3619 3478-3498 GO:0008306 denotes associative learning
T3620 3650-3653 PR:000001177 denotes D2R
T3621 3669-3676 NCBITaxon:9989 denotes rodents
T3622 3806-3810 PR:000001177 denotes D2Rs
T3623 3861-3881 GO:0008306 denotes associative learning
T3624 3885-3892 NCBITaxon:9989 denotes rodents
T3625 3933-3936 PR:000001177 denotes D2R
T3626 4104-4112 CHEBI:18243 denotes dopamine
T3627 4225-4229 PR:000001177 denotes D2Rs
T3628 4231-4235 PR:000001178 denotes D3Rs
T3629 4241-4245 PR:000001179 denotes D4Rs
T3630 4352-4356 NCBITaxon:10088 denotes mice
T3631 4372-4383 SO:0000704 denotes genetically
T3632 4442-4449 SO:0001023 denotes alleles
T3633 4580-4585 NCBITaxon:10088 denotes mouse
T3634 4709-4716 NCBITaxon:33208 denotes animals
T3635 4763-4781 GO:0007626 denotes locomotor behavior
T3636 4804-4807 PR:000001177 denotes D2R
T3637 4815-4818 PR:000001177 denotes D2R
T3638 4822-4826 NCBITaxon:10088 denotes mice
T3639 4884-4887 PR:000001177 denotes D2R
T3640 4910-4930 GO:0008306 denotes associative learning
T3641 5023-5026 PR:000001177 denotes D2R
T3642 5102-5109 SO:0000704 denotes genetic
T3643 5130-5134 PR:000001177 denotes drd2
T3644 5159-5168 GO:0007608 denotes olfactory
T3645 5187-5190 PR:000001177 denotes D2R
T3646 5194-5198 NCBITaxon:10088 denotes mice
T3647 5253-5256 PR:000001177 denotes D2R
T3648 5260-5264 NCBITaxon:10088 denotes mice
T3649 5269-5274 GO:0007612 denotes learn
T3650 5291-5295 CHEBI:33290 denotes food
T3651 5335-5342 GO:0007612 denotes learned
T3652 5427-5435 CHEBI:18243 denotes dopamine
T3653 5427-5441 PR:000001177 denotes dopamine D2R's
T3654 5480-5485 GO:0030424 denotes axons
T3655 5489-5498 GO:0007608 denotes olfactory
T3656 5489-5505 UBERON:0001579 denotes olfactory nerves
T3657 5542-5551 GO:0007608 denotes olfactory
T3658 5542-5557 UBERON:0001579 denotes olfactory nerve
T3659 5565-5580 _FRAGMENT denotes mitral cells of
T3660 5585-5599 CL:1001502 denotes olfactory bulb
T3661 5585-5594 GO:0007608 denotes olfactory
T3662 5585-5599 UBERON:0002264 denotes olfactory bulb
T3663 5696-5700 PR:000001177 denotes D2Rs
T3664 5708-5717 GO:0007608 denotes olfactory
T3665 5708-5722 UBERON:0002264 denotes olfactory bulb
T3666 5756-5765 GO:0007608 denotes olfactory
T3667 5808-5817 GO:0046959 denotes habituate
T3668 5828-5837 GO:0007608 denotes olfactory
T3669 5828-5843 UBERON:0001579 denotes olfactory nerve
T3670 5953-5956 PR:000001177 denotes D2R
T3671 5960-5964 NCBITaxon:10088 denotes mice
T3672 5981-5989 GO:0007612 denotes learning
T3673 6024-6032 CHEBI:18243 denotes dopamine
T3674 6024-6036 PR:000001177 denotes dopamine D2R
T3675 6150-6153 PR:000001177 denotes D2R
T3676 6157-6161 NCBITaxon:10088 denotes mice
T3677 6174-6177 PR:000001177 denotes D2R
T3678 6181-6185 NCBITaxon:10088 denotes mice
T3679 6202-6210 GO:0007612 denotes learning
T3680 6372-6375 PR:000001177 denotes D2R
T3681 6379-6383 NCBITaxon:10088 denotes mice
T3682 6395-6399 CHEBI:33290 denotes food
T3683 6489-6492 PR:000001175 denotes D1R
T3684 6524-6527 PR:000001177 denotes D2R
T3685 6531-6535 NCBITaxon:10088 denotes mice
T3686 6593-6601 CHEBI:18243 denotes dopamine
T3687 6593-6606 PR:000001175 denotes dopamine D1Rs
T3688 6614-6618 NCBITaxon:10088 denotes mice
T3689 6823-6831 GO:0007612 denotes learning
T3690 7014-7018 NCBITaxon:10088 denotes mice
T3691 7124-7127 PR:000001177 denotes D2R
T3692 7131-7135 NCBITaxon:10088 denotes mice
T3693 7279-7287 CHEBI:18243 denotes dopamine
T3694 7307-7315 CHEBI:18243 denotes dopamine
T3695 7307-7319 PR:000001177 denotes dopamine D2R
T3696 7340-7349 GO:0065007 denotes modulates
T3697 7504-7512 CHEBI:18243 denotes dopamine
T3698 7504-7518 CL:0000700 denotes dopamine cells
T3699 7582-7602 GO:0008306 denotes associative learning
T3700 7649-7661 CHEBI:18243 denotes dopaminergic
T3701 7649-7667 CL:0000700 denotes dopaminergic cells
T3702 7791-7803 CHEBI:18243 denotes dopaminergic
T3703 7791-7808 CL:0000700 denotes dopaminergic cell
T3704 7804-7819 GO:0001775 denotes cell activation
T3705 8000-8003 PR:000001177 denotes D2R
T3706 8007-8011 NCBITaxon:10088 denotes mice
T3707 8087-8095 CHEBI:18243 denotes dopamine
T3708 8087-8099 PR:000001177 denotes dopamine D2R
T3709 8250-8258 CHEBI:18243 denotes dopamine
T3710 8250-8263 PR:000001177 denotes dopamine D2Rs
T3711 8270-8273 PR:000001175 denotes D1R
T3712 8372-8387 UBERON:0005382 denotes dorsal striatum
T3713 8409-8412 PR:000001177 denotes D2R
T3714 8416-8420 NCBITaxon:10088 denotes mice
T3715 8480-8488 UBERON:0002435 denotes striatal
T3728 9061-9064 PR:000001177 denotes D2R
T3729 9197-9200 PR:000001177 denotes D2R
T3730 9204-9208 NCBITaxon:10088 denotes mice
T3731 9240-9248 GO:0007612 denotes learning
T3732 9333-9337 PR:000001177 denotes D2Rs
T3733 9379-9387 NCBITaxon:1 denotes organism
T3716 8489-8497 GO:0045202 denotes synaptic
T3717 8536-8551 UBERON:0005382 denotes dorsal striatum
T3718 8574-8578 NCBITaxon:10088 denotes mice
T3719 8642-8650 CL:0000540 denotes neuronal
T3720 8663-8671 UBERON:0002435 denotes striatal
T3721 8672-8681 UBERON:0006798 denotes efferents
T3722 8738-8746 CHEBI:18243 denotes dopamine
T3723 8738-8750 PR:000001177 denotes dopamine D2R
T3724 8770-8778 UBERON:0002435 denotes striatum
T3725 8933-8948 UBERON:0005382 denotes dorsal striatum
T3726 8952-8959 NCBITaxon:9989 denotes rodents
T3727 8990-8997 UBERON:0001873 denotes caudate
T3734 9391-9399 GO:0007612 denotes learning
T3735 9436-9444 GO:0007612 denotes learning
R2133 T3547 T3546 _lexicallyChainedTo learning,associative
R2134 T3576 T3575 _lexicallyChainedTo learning,associative
R2135 T3594 T3593 _lexicallyChainedTo 3,dopamine D
R2136 T3596 T3595 _lexicallyChainedTo antagonist,dopamine
R2137 T3605 T3604 _lexicallyChainedTo learning,associative
R2138 T3660 T3659 _lexicallyChainedTo olfactory bulb,mitral cells of

2_test

Id Subject Object Predicate Lexical cue
15061865-9329075-12857727 1238-1239 9329075 denotes 3
15061865-11509194-12857727 1238-1239 11509194 denotes 3
15061865-11919664-12857727 1238-1239 11919664 denotes 3
15061865-12629161-12857727 1238-1239 12629161 denotes 3
15061865-11027236-12857727 1238-1239 11027236 denotes 3
15061865-12445722-12857727 1238-1239 12445722 denotes 3
15061865-9858756-12857728 1291-1292 9858756 denotes 1
15061865-12073171-12857729 1293-1295 12073171 denotes 10
15061865-11530224-12857730 1296-1298 11530224 denotes 11
15061865-9858756-12857731 1529-1530 9858756 denotes 1
15061865-12445713-12857732 1531-1532 12445713 denotes 2
15061865-12629161-12857733 1777-1778 12629161 denotes 6
15061865-11027236-12857734 1779-1780 11027236 denotes 7
15061865-11351937-12857735 1798-1799 11351937 denotes 9
15061865-9579323-12857736 1980-1982 9579323 denotes 24
15061865-12629161-12857737 2158-2159 12629161 denotes 6
15061865-12629161-12857738 2292-2293 12629161 denotes 6
15061865-12457265-12857739 2810-2812 12457265 denotes 15
15061865-12589383-12857740 2813-2815 12589383 denotes 16
15061865-9329075-12857741 3105-3106 9329075 denotes 3
15061865-12445713-12857742 3246-3247 12445713 denotes 2
15061865-12629161-12857743 3248-3249 12629161 denotes 6
15061865-12445722-12857744 3250-3251 12445722 denotes 8
15061865-3615345-12857745 3332-3334 3615345 denotes 25
15061865-12629161-12857746 3417-3418 12629161 denotes 6
15061865-7197320-12857747 3557-3559 7197320 denotes 26
15061865-556989-12857747 3557-3559 556989 denotes 26
15061865-4277740-12857747 3557-3559 4277740 denotes 26
15061865-11229973-12857748 3812-3814 11229973 denotes 29
15061865-11731555-12857749 5601-5603 11731555 denotes 30
15061865-1357586-12857750 5604-5606 1357586 denotes 31
15061865-10444702-12857751 5928-5930 10444702 denotes 32
15061865-12629161-12857752 6512-6513 12629161 denotes 6
15061865-12649484-12857753 7610-7612 12649484 denotes 33
15061865-11257908-12857754 7762-7764 11257908 denotes 14
15061865-11257908-12857755 7899-7901 11257908 denotes 14
15061865-9169514-12857756 8327-8329 9169514 denotes 34
15061865-9169514-12857757 8683-8685 9169514 denotes 34
15061865-11264457-12857758 8713-8715 11264457 denotes 35
15061865-11144344-12857759 8961-8963 11144344 denotes 36
15061865-10742158-12857760 9021-9023 10742158 denotes 37
15061865-10484959-12857761 9117-9119 10484959 denotes 22