PMC:3989221 / 3192-4197 JSONTXT

{"project":"2_test","denotations":[{"id":"24739953-20225336-90447901","span":{"begin":162,"end":164},"obj":"20225336"},{"id":"24739953-19491929-90447902","span":{"begin":168,"end":170},"obj":"19491929"},{"id":"24739953-17435756-90447903","span":{"begin":356,"end":358},"obj":"17435756"},{"id":"24739953-21560199-90447904","span":{"begin":361,"end":363},"obj":"21560199"},{"id":"24739953-23435086-90447905","span":{"begin":387,"end":389},"obj":"23435086"},{"id":"24739953-22885761-90447906","span":{"begin":413,"end":415},"obj":"22885761"},{"id":"24739953-19750224-90447907","span":{"begin":419,"end":421},"obj":"19750224"},{"id":"24739953-22536318-90447908","span":{"begin":436,"end":438},"obj":"22536318"},{"id":"24739953-22302078-90447909","span":{"begin":784,"end":786},"obj":"22302078"}],"text":"Essential components of the autophagy process are the evolutionary highly conserved ATG proteins, of which more than 30 have currently been identified in yeasts [11], [12]. Common germline genetic variants within genes coding for autophagy components were recently demonstrated to be associated with human disease, ranging from inflammatory bowel disease [13]–[15] to neurodegeneration [16], infectious diseases [17], [18] and allergy [19]. However, despite its central role in cancer initiation and progression, the role of common germline genetic variation within the autophagy system for cancer susceptibility, in particular NMTC, is largely unexplored. Recently, we described that a genetic variant in the autophagy gene ATG16L1 has an important impact on susceptibility to NMTC [20]. In the present study we broadened the aim of our investigation to assess the potential association of a much broader range of genetic variants in autophagy genes with susceptibility for NMTC, progression and outcome."}