PMC:3989221 / 17549-18397 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"8326","span":{"begin":77,"end":86},"obj":"SNP"}],"attributes":[{"id":"A8326","pred":"resolved_to","subj":"8326","obj":"tmVar:rs2245214;VariantGroup:2;CorrespondingGene:9474;RS#:2245214;CorrespondingSpecies:9606"}],"text":"The present genetic association study revealed that the G allele of the ATG5 rs2245214 SNP is associated with increased susceptibility for developing NMTC. In contrast, this ATG5 SNP was not associated with NMTC severity and outcome as reflected by TNM staging, cumulative RAI dose and disease persistence. The fact that the genetic variants in the other selected autophagy genes are not associated with NMTC susceptibility and severity in our cohort of NMTC patients could indicate that either these proteins have no prominent role in NMTC carcinogenesis or the consequences of the genetic variants for the function of the respective proteins is relatively limited. However, replication studies in other NMTC cohorts should be performed to firmly demonstrate the lack of association of these genetic variants with NMTC susceptibility and severity."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"8326","span":{"begin":77,"end":86},"obj":"SNP"},{"id":"T1","span":{"begin":77,"end":86},"obj":"SNP"}],"attributes":[{"id":"A8326","pred":"resolved_to","subj":"8326","obj":"tmVar:rs2245214;VariantGroup:2;CorrespondingGene:9474;RS#:2245214;CorrespondingSpecies:9606"}],"text":"The present genetic association study revealed that the G allele of the ATG5 rs2245214 SNP is associated with increased susceptibility for developing NMTC. In contrast, this ATG5 SNP was not associated with NMTC severity and outcome as reflected by TNM staging, cumulative RAI dose and disease persistence. The fact that the genetic variants in the other selected autophagy genes are not associated with NMTC susceptibility and severity in our cohort of NMTC patients could indicate that either these proteins have no prominent role in NMTC carcinogenesis or the consequences of the genetic variants for the function of the respective proteins is relatively limited. However, replication studies in other NMTC cohorts should be performed to firmly demonstrate the lack of association of these genetic variants with NMTC susceptibility and severity."}