PMC:3951193 / 55231-56309 JSONTXT

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It appears likely that CB2 activation in the skin stimulates the release of β-endorphin, which then acts on peripheral μ-opioid receptors to inhibit nociception [224].\nHowever, CB1 may play a role in the central effects of EA: rats treated with EA showed reduced GABA levels in the ventrolateral periaqueductal gray, an effect reversed by CB1 blockade with AM251 [225]. Enhanced activation of epsilon protein kinase C in rat brain by EA was reversed by CB1 blockade with AM251 and not by CB2 blockade with AM630 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