PMC:3951193 / 42220-43506 JSONTXT

{"project":"2_test","denotations":[{"id":"24622769-21843633-95790293","span":{"begin":306,"end":309},"obj":"21843633"},{"id":"24622769-9872309-95790294","span":{"begin":439,"end":442},"obj":"9872309"},{"id":"24622769-11426843-95790295","span":{"begin":706,"end":709},"obj":"11426843"},{"id":"24622769-21507991-95790296","span":{"begin":791,"end":794},"obj":"21507991"},{"id":"24622769-11350214-95790297","span":{"begin":798,"end":801},"obj":"11350214"},{"id":"24622769-21172340-95790298","span":{"begin":1036,"end":1039},"obj":"21172340"},{"id":"24622769-21763743-95790299","span":{"begin":1281,"end":1284},"obj":"21763743"}],"text":"Other dietary considerations\nA natural phosphate derivative of vitamin E, α-tocopheryl phosphate (α-TP), is a common constituent in plant and animal tissues. Although α-TP does not bind to CB1, it modulates synaptic transmission in rodent hippocampus slices, an effect blocked by the CB1 antagonist AM251 [148].\nHuman breast milk contains small amounts of AEA and high levels of 2-AG, but the biological significance of this is not known [149]. The oral administration of AEA (300 mg/kg), OEA (200 mg/kg) and especially 2-AG (400 mg/kg) in rats produces calming properties [150]. Mouse breast milk also contains eCBs, and when newborn mice are fed the CB1 antagonist SR141716A, they stop suckling and die [151].\nPesticides such as chlorpyrifos and diazinon alter normal eCB system function [152], [153]. We hypothesize that eating organic foods lacking pesticide residues may promote eCB homeostasis. Piperonyl butoxide, which is a synergist added to insecticides such as pyrethrum, is an efficacious but low-potency antagonist of CB1 [154]. Phthalates are plasticizers added to water bottles, tin cans, food packaging, and even the enteric coating of pharmaceutical pills. Phthalates may act as endocrine disruptors and carcinogens. They also block CB1 as allosteric antagonists [155]."}

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Phthalates are plasticizers added to water bottles, tin cans, food packaging, and even the enteric coating of pharmaceutical pills. Phthalates may act as endocrine disruptors and carcinogens. They also block CB1 as allosteric antagonists [155]."}