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PMC:394351 / 44147-46124 JSONTXT

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Id Subject Object Predicate Lexical cue
T13432 0-5 NN denotes Abcg8
T13433 6-14 NN denotes sterolin
T13434 5-6 HYPH denotes /
T13435 17-26 JJ denotes deficient
T13436 14-15 HYPH denotes -
T13437 15-16 CD denotes 2
T13438 27-31 NNS denotes mice
T13439 37-42 VBP denotes allow
T13440 32-36 RB denotes also
T13441 43-45 PRP denotes us
T13442 49-56 VB denotes examine
T13443 46-48 TO denotes to
T13444 57-60 DT denotes the
T13445 61-65 NN denotes role
T13446 66-68 IN denotes of
T13447 69-73 DT denotes this
T13448 74-81 NN denotes protein
T13449 82-84 IN denotes in
T13450 85-92 JJ denotes biliary
T13451 93-99 NN denotes sterol
T13452 100-109 NN denotes secretion
T13453 109-110 . denotes .
T13454 110-273 sentence denotes The bile is sterol poor and upon stimulation by increasing bile salt excretion, Abcg8/sterolin-2 deficient mice cannot respond, in contrast to the wild-type mice.
T13455 111-114 DT denotes The
T13456 115-119 NN denotes bile
T13457 120-122 VBZ denotes is
T13458 123-129 NN denotes sterol
T13459 130-134 JJ denotes poor
T13460 135-138 CC denotes and
T13461 139-143 IN denotes upon
T13462 230-237 VB denotes respond
T13463 144-155 NN denotes stimulation
T13464 156-158 IN denotes by
T13465 159-169 VBG denotes increasing
T13466 170-174 NN denotes bile
T13467 175-179 NN denotes salt
T13468 180-189 NN denotes excretion
T13469 189-191 , denotes ,
T13470 191-196 NN denotes Abcg8
T13471 197-205 NN denotes sterolin
T13472 196-197 HYPH denotes /
T13473 208-217 JJ denotes deficient
T13474 205-206 HYPH denotes -
T13475 206-207 CD denotes 2
T13476 218-222 NNS denotes mice
T13477 223-226 MD denotes can
T13478 226-229 RB denotes not
T13479 237-239 , denotes ,
T13480 239-241 IN denotes in
T13481 242-250 NN denotes contrast
T13482 251-253 IN denotes to
T13483 254-257 DT denotes the
T13484 268-272 NNS denotes mice
T13485 258-262 JJ denotes wild
T13486 263-267 NN denotes type
T13487 262-263 HYPH denotes -
T13488 272-273 . denotes .
T13489 273-381 sentence denotes Thus, Abcg8/sterolin-2 is necessary for cholesterol secretion but not necessary for plant sterol secretion.
T13490 274-278 RB denotes Thus
T13491 297-299 VBZ denotes is
T13492 278-280 , denotes ,
T13493 280-285 NN denotes Abcg8
T13494 286-294 NN denotes sterolin
T13495 285-286 HYPH denotes /
T13496 294-295 HYPH denotes -
T13497 295-296 CD denotes 2
T13498 300-309 JJ denotes necessary
T13499 310-313 IN denotes for
T13500 314-325 NN denotes cholesterol
T13501 326-335 NN denotes secretion
T13502 336-339 CC denotes but
T13503 340-343 RB denotes not
T13504 344-353 JJ denotes necessary
T13505 354-357 IN denotes for
T13506 358-363 NN denotes plant
T13507 364-370 NN denotes sterol
T13508 371-380 NN denotes secretion
T13509 380-381 . denotes .
T13510 381-605 sentence denotes It could be argued that although the biliary sterol output is comparable to that seen in wild-type mice that this is inappropriately low, since the tissue and plasma pools of sitosterol are so elevated in the knockout mice.
T13511 382-384 PRP denotes It
T13512 394-400 VBN denotes argued
T13513 385-390 MD denotes could
T13514 391-393 VB denotes be
T13515 401-405 IN denotes that
T13516 496-498 VBZ denotes is
T13517 406-414 IN denotes although
T13518 441-443 VBZ denotes is
T13519 415-418 DT denotes the
T13520 434-440 NN denotes output
T13521 419-426 JJ denotes biliary
T13522 427-433 NN denotes sterol
T13523 444-454 JJ denotes comparable
T13524 455-457 IN denotes to
T13525 458-462 DT denotes that
T13526 463-467 VBN denotes seen
T13527 468-470 IN denotes in
T13528 471-475 JJ denotes wild
T13529 476-480 NN denotes type
T13530 475-476 HYPH denotes -
T13531 481-485 NNS denotes mice
T13532 486-490 IN denotes that
T13533 491-495 DT denotes this
T13534 499-514 RB denotes inappropriately
T13535 515-518 JJ denotes low
T13536 518-520 , denotes ,
T13537 520-525 IN denotes since
T13538 568-571 VBP denotes are
T13539 526-529 DT denotes the
T13540 548-553 NNS denotes pools
T13541 530-536 NN denotes tissue
T13542 537-540 CC denotes and
T13543 541-547 NN denotes plasma
T13544 554-556 IN denotes of
T13545 557-567 NN denotes sitosterol
T13546 572-574 RB denotes so
T13547 575-583 JJ denotes elevated
T13548 584-586 IN denotes in
T13549 587-590 DT denotes the
T13550 600-604 NNS denotes mice
T13551 591-599 NN denotes knockout
T13552 604-605 . denotes .
T13553 605-781 sentence denotes Despite this caveat, the findings of sitosterol in significant quantities in the bile suggests that mechanisms other than via the sterolins can 'export' some of these sterols.
T13554 606-613 IN denotes Despite
T13555 692-700 VBZ denotes suggests
T13556 614-618 DT denotes this
T13557 619-625 NN denotes caveat
T13558 625-627 , denotes ,
T13559 627-630 DT denotes the
T13560 631-639 NNS denotes findings
T13561 640-642 IN denotes of
T13562 643-653 NN denotes sitosterol
T13563 654-656 IN denotes in
T13564 657-668 JJ denotes significant
T13565 669-679 NNS denotes quantities
T13566 680-682 IN denotes in
T13567 683-686 DT denotes the
T13568 687-691 NN denotes bile
T13569 701-705 IN denotes that
T13570 751-757 VB denotes export
T13571 706-716 NNS denotes mechanisms
T13572 717-722 JJ denotes other
T13573 723-727 IN denotes than
T13574 728-731 IN denotes via
T13575 732-735 DT denotes the
T13576 736-745 NNS denotes sterolins
T13577 746-749 MD denotes can
T13578 750-751 `` denotes '
T13579 757-758 '' denotes '
T13580 759-763 DT denotes some
T13581 764-766 IN denotes of
T13582 767-772 DT denotes these
T13583 773-780 NNS denotes sterols
T13584 780-781 . denotes .
T13585 781-1018 sentence denotes Interestingly, although humans who are heterozygous for genetic defects in either ABCG5 or ABCG8 seem to be phenotypically normal, mice heterozygous for Abcg8/sterolin-2 deficiency show that sterol secretion is impaired, but not absent.
T13586 782-795 RB denotes Interestingly
T13587 963-967 VBP denotes show
T13588 795-797 , denotes ,
T13589 797-805 IN denotes although
T13590 879-883 VBP denotes seem
T13591 806-812 NNS denotes humans
T13592 813-816 WP denotes who
T13593 817-820 VBP denotes are
T13594 821-833 JJ denotes heterozygous
T13595 834-837 IN denotes for
T13596 838-845 JJ denotes genetic
T13597 846-853 NNS denotes defects
T13598 854-856 IN denotes in
T13599 857-863 CC denotes either
T13600 864-869 NN denotes ABCG5
T13601 870-872 CC denotes or
T13602 873-878 NN denotes ABCG8
T13603 884-886 TO denotes to
T13604 887-889 VB denotes be
T13605 890-904 RB denotes phenotypically
T13606 905-911 JJ denotes normal
T13607 911-913 , denotes ,
T13608 913-917 NNS denotes mice
T13609 918-930 JJ denotes heterozygous
T13610 931-934 IN denotes for
T13611 935-940 NN denotes Abcg8
T13612 941-949 NN denotes sterolin
T13613 940-941 HYPH denotes /
T13614 952-962 NN denotes deficiency
T13615 949-950 HYPH denotes -
T13616 950-951 CD denotes 2
T13617 968-972 IN denotes that
T13618 990-992 VBZ denotes is
T13619 973-979 NN denotes sterol
T13620 980-989 NN denotes secretion
T13621 993-1001 JJ denotes impaired
T13622 1001-1003 , denotes ,
T13623 1003-1006 CC denotes but
T13624 1007-1010 RB denotes not
T13625 1011-1017 JJ denotes absent
T13626 1017-1018 . denotes .
T13627 1018-1245 sentence denotes Note that under steady-state conditions on a rodent chow diet, heterozygous animals show no significant elevations in plasma or tissue sitosterol levels, suggesting that the activity of these proteins may not be rate limiting.
T13628 1019-1023 VB denotes Note
T13629 1024-1028 IN denotes that
T13630 1103-1107 VBP denotes show
T13631 1029-1034 IN denotes under
T13632 1035-1041 JJ denotes steady
T13633 1042-1047 NN denotes state
T13634 1041-1042 HYPH denotes -
T13635 1048-1058 NNS denotes conditions
T13636 1059-1061 IN denotes on
T13637 1062-1063 DT denotes a
T13638 1076-1080 NN denotes diet
T13639 1064-1070 NN denotes rodent
T13640 1071-1075 NN denotes chow
T13641 1080-1082 , denotes ,
T13642 1082-1094 JJ denotes heterozygous
T13643 1095-1102 NNS denotes animals
T13644 1108-1110 DT denotes no
T13645 1123-1133 NNS denotes elevations
T13646 1111-1122 JJ denotes significant
T13647 1134-1136 IN denotes in
T13648 1137-1143 NN denotes plasma
T13649 1154-1164 NN denotes sitosterol
T13650 1144-1146 CC denotes or
T13651 1147-1153 NN denotes tissue
T13652 1165-1171 NNS denotes levels
T13653 1171-1173 , denotes ,
T13654 1173-1183 VBG denotes suggesting
T13655 1184-1188 IN denotes that
T13656 1228-1230 VB denotes be
T13657 1189-1192 DT denotes the
T13658 1193-1201 NN denotes activity
T13659 1202-1204 IN denotes of
T13660 1205-1210 DT denotes these
T13661 1211-1219 NN denotes proteins
T13662 1220-1223 MD denotes may
T13663 1224-1227 RB denotes not
T13664 1231-1235 NN denotes rate
T13665 1236-1244 VBG denotes limiting
T13666 1244-1245 . denotes .
T13667 1245-1364 sentence denotes Furthermore, the heterozygous Abcg8+/- mice showed higher levels of biliary sitosterol relative to the wild-type mice.
T13668 1246-1257 RB denotes Furthermore
T13669 1290-1296 VBD denotes showed
T13670 1257-1259 , denotes ,
T13671 1259-1262 DT denotes the
T13672 1285-1289 NNS denotes mice
T13673 1263-1275 JJ denotes heterozygous
T13674 1276-1281 NN denotes Abcg8
T13675 1281-1282 SYM denotes +
T13676 1282-1283 HYPH denotes /
T13677 1283-1284 SYM denotes -
T13678 1297-1303 JJR denotes higher
T13679 1304-1310 NNS denotes levels
T13680 1311-1313 IN denotes of
T13681 1314-1321 JJ denotes biliary
T13682 1322-1332 NN denotes sitosterol
T13683 1333-1341 JJ denotes relative
T13684 1342-1344 IN denotes to
T13685 1345-1348 DT denotes the
T13686 1359-1363 NNS denotes mice
T13687 1349-1353 JJ denotes wild
T13688 1354-1358 NN denotes type
T13689 1353-1354 HYPH denotes -
T13690 1363-1364 . denotes .
T13691 1364-1626 sentence denotes While the rate of total biliary sterol secretion is reduced compared to wild-type mice, since the heterozygous mice are not sitosterolemic, either the activity of these proteins is not rate limiting or other mechanisms can compensate for a 50% loss of activity.
T13692 1365-1370 IN denotes While
T13693 1417-1424 VBN denotes reduced
T13694 1371-1374 DT denotes the
T13695 1375-1379 NN denotes rate
T13696 1380-1382 IN denotes of
T13697 1383-1388 JJ denotes total
T13698 1404-1413 NN denotes secretion
T13699 1389-1396 JJ denotes biliary
T13700 1397-1403 NN denotes sterol
T13701 1414-1416 VBZ denotes is
T13702 1543-1545 VBZ denotes is
T13703 1425-1433 VBN denotes compared
T13704 1434-1436 IN denotes to
T13705 1437-1441 JJ denotes wild
T13706 1442-1446 NN denotes type
T13707 1441-1442 HYPH denotes -
T13708 1447-1451 NNS denotes mice
T13709 1451-1453 , denotes ,
T13710 1453-1458 IN denotes since
T13711 1481-1484 VBP denotes are
T13712 1459-1462 DT denotes the
T13713 1476-1480 NNS denotes mice
T13714 1463-1475 JJ denotes heterozygous
T13715 1485-1488 RB denotes not
T13716 1489-1503 JJ denotes sitosterolemic
T13717 1503-1505 , denotes ,
T13718 1505-1511 CC denotes either
T13719 1512-1515 DT denotes the
T13720 1516-1524 NN denotes activity
T13721 1525-1527 IN denotes of
T13722 1528-1533 DT denotes these
T13723 1534-1542 NN denotes proteins
T13724 1546-1549 RB denotes not
T13725 1550-1554 NN denotes rate
T13726 1555-1563 VBG denotes limiting
T13727 1564-1566 CC denotes or
T13728 1567-1572 JJ denotes other
T13729 1573-1583 NNS denotes mechanisms
T13730 1588-1598 VB denotes compensate
T13731 1584-1587 MD denotes can
T13732 1599-1602 IN denotes for
T13733 1603-1604 DT denotes a
T13734 1609-1613 NN denotes loss
T13735 1605-1607 CD denotes 50
T13736 1607-1608 NN denotes %
T13737 1614-1616 IN denotes of
T13738 1617-1625 NN denotes activity
T13739 1625-1626 . denotes .
T13740 1626-1852 sentence denotes On the other hand, since feeding is intermittent, a slow, but continuous secretion during post-prandial periods could easily negate any mild temporary increase in tissue and plasma plant sterol levels in heterozygous animals.
T13741 1627-1629 IN denotes On
T13742 1752-1758 VB denotes negate
T13743 1630-1633 DT denotes the
T13744 1640-1644 NN denotes hand
T13745 1634-1639 JJ denotes other
T13746 1644-1646 , denotes ,
T13747 1646-1651 IN denotes since
T13748 1660-1662 VBZ denotes is
T13749 1652-1659 NN denotes feeding
T13750 1663-1675 JJ denotes intermittent
T13751 1675-1677 , denotes ,
T13752 1677-1678 DT denotes a
T13753 1700-1709 NN denotes secretion
T13754 1679-1683 JJ denotes slow
T13755 1683-1685 , denotes ,
T13756 1685-1688 CC denotes but
T13757 1689-1699 JJ denotes continuous
T13758 1710-1716 IN denotes during
T13759 1717-1730 JJ denotes post-prandial
T13760 1731-1738 NNS denotes periods
T13761 1739-1744 MD denotes could
T13762 1745-1751 RB denotes easily
T13763 1759-1762 DT denotes any
T13764 1778-1786 NN denotes increase
T13765 1763-1767 JJ denotes mild
T13766 1768-1777 JJ denotes temporary
T13767 1787-1789 IN denotes in
T13768 1790-1796 NN denotes tissue
T13769 1821-1827 NNS denotes levels
T13770 1797-1800 CC denotes and
T13771 1801-1807 NN denotes plasma
T13772 1808-1813 NN denotes plant
T13773 1814-1820 NN denotes sterol
T13774 1828-1830 IN denotes in
T13775 1831-1843 JJ denotes heterozygous
T13776 1844-1851 NNS denotes animals
T13777 1851-1852 . denotes .
T13778 1852-1977 sentence denotes This may be amenable to testing by placing these animals on a high plant sterol diet and measuring the plasma sterol levels.
T13779 1853-1857 DT denotes This
T13780 1862-1864 VB denotes be
T13781 1858-1861 MD denotes may
T13782 1865-1873 JJ denotes amenable
T13783 1874-1876 IN denotes to
T13784 1877-1884 VBG denotes testing
T13785 1885-1887 IN denotes by
T13786 1888-1895 VBG denotes placing
T13787 1896-1901 DT denotes these
T13788 1902-1909 NNS denotes animals
T13789 1910-1912 IN denotes on
T13790 1913-1914 DT denotes a
T13791 1933-1937 NN denotes diet
T13792 1915-1919 JJ denotes high
T13793 1926-1932 NN denotes sterol
T13794 1920-1925 NN denotes plant
T13795 1938-1941 CC denotes and
T13796 1942-1951 VBG denotes measuring
T13797 1952-1955 DT denotes the
T13798 1970-1976 NNS denotes levels
T13799 1956-1962 NN denotes plasma
T13800 1963-1969 NN denotes sterol
T13801 1976-1977 . denotes .
R8351 T13432 T13433 compound Abcg8,sterolin
R8352 T13433 T13435 npadvmod sterolin,deficient
R8353 T13434 T13433 punct /,sterolin
R8354 T13435 T13438 amod deficient,mice
R8355 T13436 T13433 punct -,sterolin
R8356 T13437 T13433 nummod 2,sterolin
R8357 T13438 T13439 nsubj mice,allow
R8358 T13440 T13439 advmod also,allow
R8359 T13441 T13442 nsubj us,examine
R8360 T13442 T13439 ccomp examine,allow
R8361 T13443 T13442 aux to,examine
R8362 T13444 T13445 det the,role
R8363 T13445 T13442 dobj role,examine
R8364 T13446 T13445 prep of,role
R8365 T13447 T13448 det this,protein
R8366 T13448 T13446 pobj protein,of
R8367 T13449 T13445 prep in,role
R8368 T13450 T13451 amod biliary,sterol
R8369 T13451 T13452 compound sterol,secretion
R8370 T13452 T13449 pobj secretion,in
R8371 T13453 T13439 punct .,allow
R8372 T13455 T13456 det The,bile
R8373 T13456 T13457 nsubj bile,is
R8374 T13458 T13459 npadvmod sterol,poor
R8375 T13459 T13457 acomp poor,is
R8376 T13460 T13457 cc and,is
R8377 T13461 T13462 prep upon,respond
R8378 T13462 T13457 conj respond,is
R8379 T13463 T13461 pobj stimulation,upon
R8380 T13464 T13463 prep by,stimulation
R8381 T13465 T13464 pcomp increasing,by
R8382 T13466 T13467 compound bile,salt
R8383 T13467 T13468 compound salt,excretion
R8384 T13468 T13465 dobj excretion,increasing
R8385 T13469 T13462 punct ", ",respond
R8386 T13470 T13471 compound Abcg8,sterolin
R8387 T13471 T13473 npadvmod sterolin,deficient
R8388 T13472 T13471 punct /,sterolin
R8389 T13473 T13476 amod deficient,mice
R8390 T13474 T13471 punct -,sterolin
R8391 T13475 T13471 nummod 2,sterolin
R8392 T13476 T13462 nsubj mice,respond
R8393 T13477 T13462 aux can,respond
R8394 T13478 T13462 neg not,respond
R8395 T13479 T13462 punct ", ",respond
R8396 T13480 T13462 prep in,respond
R8397 T13481 T13480 pobj contrast,in
R8398 T13482 T13481 prep to,contrast
R8399 T13483 T13484 det the,mice
R8400 T13484 T13482 pobj mice,to
R8401 T13485 T13486 amod wild,type
R8402 T13486 T13484 compound type,mice
R8403 T13487 T13486 punct -,type
R8404 T13488 T13462 punct .,respond
R8405 T13490 T13491 advmod Thus,is
R8406 T13492 T13491 punct ", ",is
R8407 T13493 T13494 compound Abcg8,sterolin
R8408 T13494 T13491 nsubj sterolin,is
R8409 T13495 T13494 punct /,sterolin
R8410 T13496 T13494 punct -,sterolin
R8411 T13497 T13494 nummod 2,sterolin
R8412 T13498 T13491 acomp necessary,is
R8413 T13499 T13498 prep for,necessary
R8414 T13500 T13501 compound cholesterol,secretion
R8415 T13501 T13499 pobj secretion,for
R8416 T13502 T13498 cc but,necessary
R8417 T13503 T13502 neg not,but
R8418 T13504 T13498 conj necessary,necessary
R8419 T13505 T13504 prep for,necessary
R8420 T13506 T13507 compound plant,sterol
R8421 T13507 T13508 compound sterol,secretion
R8422 T13508 T13505 pobj secretion,for
R8423 T13509 T13491 punct .,is
R8424 T13511 T13512 nsubjpass It,argued
R8425 T13513 T13512 aux could,argued
R8426 T13514 T13512 auxpass be,argued
R8427 T13515 T13516 mark that,is
R8428 T13516 T13512 ccomp is,argued
R8429 T13517 T13518 mark although,is
R8430 T13518 T13516 advcl is,is
R8431 T13519 T13520 det the,output
R8432 T13520 T13518 nsubj output,is
R8433 T13521 T13522 amod biliary,sterol
R8434 T13522 T13520 compound sterol,output
R8435 T13523 T13518 acomp comparable,is
R8436 T13524 T13523 prep to,comparable
R8437 T13525 T13524 pobj that,to
R8438 T13526 T13525 acl seen,that
R8439 T13527 T13526 prep in,seen
R8440 T13528 T13529 amod wild,type
R8441 T13529 T13531 compound type,mice
R8442 T13530 T13529 punct -,type
R8443 T13531 T13527 pobj mice,in
R8444 T13532 T13516 mark that,is
R8445 T13533 T13516 nsubj this,is
R8446 T13534 T13535 advmod inappropriately,low
R8447 T13535 T13516 acomp low,is
R8448 T13536 T13512 punct ", ",argued
R8449 T13537 T13538 mark since,are
R8450 T13538 T13512 advcl are,argued
R8451 T13539 T13540 det the,pools
R8452 T13540 T13538 nsubj pools,are
R8453 T13541 T13540 nmod tissue,pools
R8454 T13542 T13541 cc and,tissue
R8455 T13543 T13541 conj plasma,tissue
R8456 T13544 T13540 prep of,pools
R8457 T13545 T13544 pobj sitosterol,of
R8458 T13546 T13547 advmod so,elevated
R8459 T13547 T13538 acomp elevated,are
R8460 T13548 T13538 prep in,are
R8461 T13549 T13550 det the,mice
R8462 T13550 T13548 pobj mice,in
R8463 T13551 T13550 compound knockout,mice
R8464 T13552 T13512 punct .,argued
R8465 T13554 T13555 prep Despite,suggests
R8466 T13556 T13557 det this,caveat
R8467 T13557 T13554 pobj caveat,Despite
R8468 T13558 T13555 punct ", ",suggests
R8469 T13559 T13560 det the,findings
R8470 T13560 T13555 nsubj findings,suggests
R8471 T13561 T13560 prep of,findings
R8472 T13562 T13561 pobj sitosterol,of
R8473 T13563 T13562 prep in,sitosterol
R8474 T13564 T13565 amod significant,quantities
R8475 T13565 T13563 pobj quantities,in
R8476 T13566 T13562 prep in,sitosterol
R8477 T13567 T13568 det the,bile
R8478 T13568 T13566 pobj bile,in
R8479 T13569 T13570 mark that,export
R8480 T13570 T13555 ccomp export,suggests
R8481 T13571 T13570 nsubj mechanisms,export
R8482 T13572 T13571 amod other,mechanisms
R8483 T13573 T13572 prep than,other
R8484 T13574 T13573 prep via,than
R8485 T13575 T13576 det the,sterolins
R8486 T13576 T13574 pobj sterolins,via
R8487 T13577 T13570 aux can,export
R8488 T13578 T13570 punct ',export
R8489 T13579 T13570 punct ',export
R8490 T13580 T13570 dobj some,export
R8491 T13581 T13580 prep of,some
R8492 T13582 T13583 det these,sterols
R8493 T13583 T13581 pobj sterols,of
R8494 T13584 T13555 punct .,suggests
R8495 T13586 T13587 advmod Interestingly,show
R8496 T13588 T13587 punct ", ",show
R8497 T13589 T13590 mark although,seem
R8498 T13590 T13587 advcl seem,show
R8499 T13591 T13590 nsubj humans,seem
R8500 T13592 T13593 dep who,are
R8501 T13593 T13591 relcl are,humans
R8502 T13594 T13593 acomp heterozygous,are
R8503 T13595 T13594 prep for,heterozygous
R8504 T13596 T13597 amod genetic,defects
R8505 T13597 T13595 pobj defects,for
R8506 T13598 T13597 prep in,defects
R8507 T13599 T13600 preconj either,ABCG5
R8508 T13600 T13598 pobj ABCG5,in
R8509 T13601 T13600 cc or,ABCG5
R8510 T13602 T13600 conj ABCG8,ABCG5
R8511 T13603 T13604 aux to,be
R8512 T13604 T13590 xcomp be,seem
R8513 T13605 T13606 advmod phenotypically,normal
R8514 T13606 T13604 acomp normal,be
R8515 T13607 T13587 punct ", ",show
R8516 T13608 T13587 nsubj mice,show
R8517 T13609 T13608 amod heterozygous,mice
R8518 T13610 T13609 prep for,heterozygous
R8519 T13611 T13612 nmod Abcg8,sterolin
R8520 T13612 T13614 nmod sterolin,deficiency
R8521 T13613 T13612 punct /,sterolin
R8522 T13614 T13610 pobj deficiency,for
R8523 T13615 T13612 punct -,sterolin
R8524 T13616 T13612 nummod 2,sterolin
R8525 T13617 T13618 mark that,is
R8526 T13618 T13587 ccomp is,show
R8527 T13619 T13620 compound sterol,secretion
R8528 T13620 T13618 nsubj secretion,is
R8529 T13621 T13618 acomp impaired,is
R8530 T13622 T13621 punct ", ",impaired
R8531 T13623 T13621 cc but,impaired
R8532 T13624 T13623 neg not,but
R8533 T13625 T13621 conj absent,impaired
R8534 T13626 T13587 punct .,show
R8535 T13629 T13630 mark that,show
R8536 T13630 T13628 ccomp show,Note
R8537 T13631 T13630 prep under,show
R8538 T13632 T13633 amod steady,state
R8539 T13633 T13635 compound state,conditions
R8540 T13634 T13633 punct -,state
R8541 T13635 T13631 pobj conditions,under
R8542 T13636 T13630 prep on,show
R8543 T13637 T13638 det a,diet
R8544 T13638 T13636 pobj diet,on
R8545 T13639 T13640 compound rodent,chow
R8546 T13640 T13638 compound chow,diet
R8547 T13641 T13630 punct ", ",show
R8548 T13642 T13643 amod heterozygous,animals
R8549 T13643 T13630 nsubj animals,show
R8550 T13644 T13645 det no,elevations
R8551 T13645 T13630 dobj elevations,show
R8552 T13646 T13645 amod significant,elevations
R8553 T13647 T13645 prep in,elevations
R8554 T13648 T13649 nmod plasma,sitosterol
R8555 T13649 T13652 compound sitosterol,levels
R8556 T13650 T13648 cc or,plasma
R8557 T13651 T13648 conj tissue,plasma
R8558 T13652 T13647 pobj levels,in
R8559 T13653 T13630 punct ", ",show
R8560 T13654 T13630 advcl suggesting,show
R8561 T13655 T13656 mark that,be
R8562 T13656 T13654 ccomp be,suggesting
R8563 T13657 T13658 det the,activity
R8564 T13658 T13656 nsubj activity,be
R8565 T13659 T13658 prep of,activity
R8566 T13660 T13661 det these,proteins
R8567 T13661 T13659 pobj proteins,of
R8568 T13662 T13656 aux may,be
R8569 T13663 T13656 neg not,be
R8570 T13664 T13665 npadvmod rate,limiting
R8571 T13665 T13656 acomp limiting,be
R8572 T13666 T13628 punct .,Note
R8573 T13668 T13669 advmod Furthermore,showed
R8574 T13670 T13669 punct ", ",showed
R8575 T13671 T13672 det the,mice
R8576 T13672 T13669 nsubj mice,showed
R8577 T13673 T13672 amod heterozygous,mice
R8578 T13674 T13672 nmod Abcg8,mice
R8579 T13675 T13674 punct +,Abcg8
R8580 T13676 T13674 punct /,Abcg8
R8581 T13677 T13674 punct -,Abcg8
R8582 T13678 T13679 amod higher,levels
R8583 T13679 T13669 dobj levels,showed
R8584 T13680 T13679 prep of,levels
R8585 T13681 T13682 amod biliary,sitosterol
R8586 T13682 T13680 pobj sitosterol,of
R8587 T13683 T13679 amod relative,levels
R8588 T13684 T13683 prep to,relative
R8589 T13685 T13686 det the,mice
R8590 T13686 T13684 pobj mice,to
R8591 T13687 T13688 amod wild,type
R8592 T13688 T13686 compound type,mice
R8593 T13689 T13688 punct -,type
R8594 T13690 T13669 punct .,showed
R8595 T13692 T13693 mark While,reduced
R8596 T13693 T13702 advcl reduced,is
R8597 T13694 T13695 det the,rate
R8598 T13695 T13693 nsubjpass rate,reduced
R8599 T13696 T13695 prep of,rate
R8600 T13697 T13698 amod total,secretion
R8601 T13698 T13696 pobj secretion,of
R8602 T13699 T13700 amod biliary,sterol
R8603 T13700 T13698 compound sterol,secretion
R8604 T13701 T13693 auxpass is,reduced
R8605 T13703 T13693 prep compared,reduced
R8606 T13704 T13703 prep to,compared
R8607 T13705 T13706 amod wild,type
R8608 T13706 T13708 compound type,mice
R8609 T13707 T13706 punct -,type
R8610 T13708 T13704 pobj mice,to
R8611 T13709 T13693 punct ", ",reduced
R8612 T13710 T13711 mark since,are
R8613 T13711 T13693 advcl are,reduced
R8614 T13712 T13713 det the,mice
R8615 T13713 T13711 nsubj mice,are
R8616 T13714 T13713 amod heterozygous,mice
R8617 T13715 T13711 neg not,are
R8618 T13716 T13711 acomp sitosterolemic,are
R8619 T13717 T13702 punct ", ",is
R8620 T13718 T13702 preconj either,is
R8621 T13719 T13720 det the,activity
R8622 T13720 T13702 nsubj activity,is
R8623 T13721 T13720 prep of,activity
R8624 T13722 T13723 det these,proteins
R8625 T13723 T13721 pobj proteins,of
R8626 T13724 T13702 neg not,is
R8627 T13725 T13726 npadvmod rate,limiting
R8628 T13726 T13702 acomp limiting,is
R8629 T13727 T13702 cc or,is
R8630 T13728 T13729 amod other,mechanisms
R8631 T13729 T13730 nsubj mechanisms,compensate
R8632 T13730 T13702 conj compensate,is
R8633 T13731 T13730 aux can,compensate
R8634 T13732 T13730 prep for,compensate
R8635 T13733 T13734 det a,loss
R8636 T13734 T13732 pobj loss,for
R8637 T13735 T13736 nummod 50,%
R8638 T13736 T13734 compound %,loss
R8639 T13737 T13734 prep of,loss
R8640 T13738 T13737 pobj activity,of
R8641 T13739 T13730 punct .,compensate
R8642 T13741 T13742 prep On,negate
R8643 T13743 T13744 det the,hand
R8644 T13744 T13741 pobj hand,On
R8645 T13745 T13744 amod other,hand
R8646 T13746 T13742 punct ", ",negate
R8647 T13747 T13748 mark since,is
R8648 T13748 T13742 advcl is,negate
R8649 T13749 T13748 nsubj feeding,is
R8650 T13750 T13748 acomp intermittent,is
R8651 T13751 T13742 punct ", ",negate
R8652 T13752 T13753 det a,secretion
R8653 T13753 T13742 nsubj secretion,negate
R8654 T13754 T13753 amod slow,secretion
R8655 T13755 T13754 punct ", ",slow
R8656 T13756 T13754 cc but,slow
R8657 T13757 T13754 conj continuous,slow
R8658 T13758 T13753 prep during,secretion
R8659 T13759 T13760 amod post-prandial,periods
R8660 T13760 T13758 pobj periods,during
R8661 T13761 T13742 aux could,negate
R8662 T13762 T13742 advmod easily,negate
R8663 T13763 T13764 det any,increase
R8664 T13764 T13742 dobj increase,negate
R8665 T13765 T13764 amod mild,increase
R8666 T13766 T13764 amod temporary,increase
R8667 T13767 T13764 prep in,increase
R8668 T13768 T13769 nmod tissue,levels
R8669 T13769 T13767 pobj levels,in
R8670 T13770 T13768 cc and,tissue
R8671 T13771 T13768 conj plasma,tissue
R8672 T13772 T13773 compound plant,sterol
R8673 T13773 T13769 compound sterol,levels
R8674 T13774 T13764 prep in,increase
R8675 T13775 T13776 amod heterozygous,animals
R8676 T13776 T13774 pobj animals,in
R8677 T13777 T13742 punct .,negate
R8678 T13779 T13780 nsubj This,be
R8679 T13781 T13780 aux may,be
R8680 T13782 T13780 acomp amenable,be
R8681 T13783 T13782 prep to,amenable
R8682 T13784 T13783 pcomp testing,to
R8683 T13785 T13784 prep by,testing
R8684 T13786 T13785 pcomp placing,by
R8685 T13787 T13788 det these,animals
R8686 T13788 T13786 dobj animals,placing
R8687 T13789 T13786 prep on,placing
R8688 T13790 T13791 det a,diet
R8689 T13791 T13789 pobj diet,on
R8690 T13792 T13793 amod high,sterol
R8691 T13793 T13791 compound sterol,diet
R8692 T13794 T13793 compound plant,sterol
R8693 T13795 T13786 cc and,placing
R8694 T13796 T13786 conj measuring,placing
R8695 T13797 T13798 det the,levels
R8696 T13798 T13796 dobj levels,measuring
R8697 T13799 T13800 compound plasma,sterol
R8698 T13800 T13798 compound sterol,levels
R8699 T13801 T13780 punct .,be

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T12303 0-5 PR_EXT:000003573 denotes Abcg8
T12304 6-16 PR_EXT:000003573 denotes sterolin-2
T12305 27-31 NCBITaxon:10088 denotes mice
T12306 74-81 CHEBI_PR_EXT:protein denotes protein
T12307 85-92 UBERON:0002294 denotes biliary
T12309 100-109 GO_EXT:secretion_entity_or_process denotes secretion
T12310 115-119 UBERON:0001970 denotes bile
T12311 123-129 CHEBI:15889 denotes sterol
T12312 170-174 UBERON:0001970 denotes bile
T12313 170-179 CHEBI:22868 denotes bile salt
T12314 180-189 GO:0007588 denotes excretion
T12315 191-196 PR_EXT:000003573 denotes Abcg8
T12316 197-207 PR_EXT:000003573 denotes sterolin-2
T12317 218-222 NCBITaxon:10088 denotes mice
T12318 230-237 GO_EXT:reaction_or_response denotes respond
T12319 258-267 SO_EXT:wild_type_entity_or_quality denotes wild-type
T12320 268-272 NCBITaxon:10088 denotes mice
T12321 280-285 PR_EXT:000003573 denotes Abcg8
T12322 286-296 PR_EXT:000003573 denotes sterolin-2
T12323 314-325 CHEBI:16113 denotes cholesterol
T12324 326-335 GO_EXT:secretion_entity_or_process denotes secretion
T12325 358-363 NCBITaxon:3193 denotes plant
T12326 364-370 CHEBI:15889 denotes sterol
T12327 371-380 GO_EXT:secretion_entity_or_process denotes secretion
T12328 419-426 UBERON:0002294 denotes biliary
T12329 427-433 CHEBI:15889 denotes sterol
T12330 471-480 SO_EXT:wild_type_entity_or_quality denotes wild-type
T12331 481-485 NCBITaxon:10088 denotes mice
T12332 530-536 UBERON:0000479 denotes tissue
T12333 541-547 UBERON:0001969 denotes plasma
T12334 557-567 CHEBI:27693 denotes sitosterol
T12335 600-604 NCBITaxon:10088 denotes mice
T12336 643-653 CHEBI:27693 denotes sitosterol
T12337 687-691 UBERON:0001970 denotes bile
T12338 736-745 PR_EXT:sterolin denotes sterolins
T12339 751-757 GO_RO_EXT:biological_export denotes export
T12340 773-780 CHEBI:15889 denotes sterols
T12341 806-812 NCBITaxon:9606 denotes humans
T12342 838-845 SO_EXT:0000704 denotes genetic
T12343 864-869 PR_EXT:000003572 denotes ABCG5
T12344 873-878 PR_EXT:000003573 denotes ABCG8
T12345 913-917 NCBITaxon:10088 denotes mice
T12346 935-940 PR_EXT:000003573 denotes Abcg8
T12347 941-951 PR_EXT:000003573 denotes sterolin-2
T12348 973-979 CHEBI:15889 denotes sterol
T12349 980-989 GO_EXT:secretion_entity_or_process denotes secretion
T12350 1064-1070 NCBITaxon:9989 denotes rodent
T12351 1071-1075 CHEBI_EXT:33290 denotes chow
T12352 1095-1102 NCBITaxon:33208 denotes animals
T12353 1137-1143 UBERON:0001969 denotes plasma
T12354 1147-1153 UBERON:0000479 denotes tissue
T12355 1154-1164 CHEBI:27693 denotes sitosterol
T12356 1211-1219 CHEBI_PR_EXT:protein denotes proteins
T12357 1276-1281 PR_EXT:000003573 denotes Abcg8
T12358 1281-1282 SO_EXT:normal_or_wild_type_or_present denotes +
T12359 1283-1284 SO_EXT:sequence_nullness_or_absence denotes -
T12360 1285-1289 NCBITaxon:10088 denotes mice
T12361 1314-1321 UBERON:0002294 denotes biliary
T12362 1322-1332 CHEBI:27693 denotes sitosterol
T12363 1349-1358 SO_EXT:wild_type_entity_or_quality denotes wild-type
T12364 1359-1363 NCBITaxon:10088 denotes mice
T12365 1389-1396 UBERON:0002294 denotes biliary
T12366 1397-1403 CHEBI:15889 denotes sterol
T12367 1404-1413 GO_EXT:secretion_entity_or_process denotes secretion
T12368 1437-1446 SO_EXT:wild_type_entity_or_quality denotes wild-type
T12369 1447-1451 NCBITaxon:10088 denotes mice
T12370 1476-1480 NCBITaxon:10088 denotes mice
T12371 1534-1542 CHEBI_PR_EXT:protein denotes proteins
T12372 1652-1659 GO:0007631 denotes feeding
T12373 1700-1709 GO_EXT:secretion_entity_or_process denotes secretion
T12374 1790-1796 UBERON:0000479 denotes tissue
T12375 1801-1807 UBERON:0001969 denotes plasma
T12376 1808-1813 NCBITaxon:3193 denotes plant
T12377 1814-1820 CHEBI:15889 denotes sterol
T12378 1844-1851 NCBITaxon:33208 denotes animals
T12379 1902-1909 NCBITaxon:33208 denotes animals
T12380 1920-1925 NCBITaxon:3193 denotes plant
T12381 1926-1932 CHEBI:15889 denotes sterol
T12382 1956-1962 UBERON:0001969 denotes plasma
T12383 1963-1969 CHEBI:15889 denotes sterol
T12308 93-99 CHEBI:15889 denotes sterol

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T11935 0-5 PR:000003573 denotes Abcg8
T11936 6-16 PR:000003573 denotes sterolin-2
T11937 27-31 NCBITaxon:10088 denotes mice
T11938 85-92 UBERON:0002294 denotes biliary
T11939 93-99 CHEBI:15889 denotes sterol
T11940 115-119 UBERON:0001970 denotes bile
T11941 123-129 CHEBI:15889 denotes sterol
T11942 170-174 UBERON:0001970 denotes bile
T11943 170-179 CHEBI:22868 denotes bile salt
T11944 180-189 GO:0007588 denotes excretion
T11945 191-196 PR:000003573 denotes Abcg8
T11946 197-207 PR:000003573 denotes sterolin-2
T11947 218-222 NCBITaxon:10088 denotes mice
T11948 268-272 NCBITaxon:10088 denotes mice
T11949 280-285 PR:000003573 denotes Abcg8
T11950 286-296 PR:000003573 denotes sterolin-2
T11951 314-325 CHEBI:16113 denotes cholesterol
T11952 358-363 NCBITaxon:3193 denotes plant
T11953 364-370 CHEBI:15889 denotes sterol
T11954 419-426 UBERON:0002294 denotes biliary
T11955 427-433 CHEBI:15889 denotes sterol
T11956 481-485 NCBITaxon:10088 denotes mice
T11957 530-536 UBERON:0000479 denotes tissue
T11958 541-547 UBERON:0001969 denotes plasma
T11959 557-567 CHEBI:27693 denotes sitosterol
T11960 600-604 NCBITaxon:10088 denotes mice
T11961 643-653 CHEBI:27693 denotes sitosterol
T11962 687-691 UBERON:0001970 denotes bile
T11963 773-780 CHEBI:15889 denotes sterols
T11964 806-812 NCBITaxon:9606 denotes humans
T11965 838-845 SO:0000704 denotes genetic
T11966 864-869 PR:000003572 denotes ABCG5
T11967 873-878 PR:000003573 denotes ABCG8
T11968 913-917 NCBITaxon:10088 denotes mice
T11969 935-940 PR:000003573 denotes Abcg8
T11970 941-951 PR:000003573 denotes sterolin-2
T11971 973-979 CHEBI:15889 denotes sterol
T11972 1064-1070 NCBITaxon:9989 denotes rodent
T11973 1071-1075 CHEBI:33290 denotes chow
T11974 1095-1102 NCBITaxon:33208 denotes animals
T11975 1137-1143 UBERON:0001969 denotes plasma
T11976 1147-1153 UBERON:0000479 denotes tissue
T11977 1154-1164 CHEBI:27693 denotes sitosterol
T11978 1276-1281 PR:000003573 denotes Abcg8
T11979 1285-1289 NCBITaxon:10088 denotes mice
T11980 1314-1321 UBERON:0002294 denotes biliary
T11981 1322-1332 CHEBI:27693 denotes sitosterol
T11982 1359-1363 NCBITaxon:10088 denotes mice
T11983 1389-1396 UBERON:0002294 denotes biliary
T11984 1397-1403 CHEBI:15889 denotes sterol
T11985 1447-1451 NCBITaxon:10088 denotes mice
T11986 1476-1480 NCBITaxon:10088 denotes mice
T11987 1652-1659 GO:0007631 denotes feeding
T11988 1790-1796 UBERON:0000479 denotes tissue
T11989 1801-1807 UBERON:0001969 denotes plasma
T11990 1808-1813 NCBITaxon:3193 denotes plant
T11991 1814-1820 CHEBI:15889 denotes sterol
T11992 1844-1851 NCBITaxon:33208 denotes animals
T11993 1902-1909 NCBITaxon:33208 denotes animals
T11994 1920-1925 NCBITaxon:3193 denotes plant
T11995 1926-1932 CHEBI:15889 denotes sterol
T11996 1956-1962 UBERON:0001969 denotes plasma
T11997 1963-1969 CHEBI:15889 denotes sterol