PMC:394351 / 32227-33014 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T9274","span":{"begin":0,"end":2},"obj":"TO"},{"id":"T9275","span":{"begin":3,"end":9},"obj":"VB"},{"id":"T9276","span":{"begin":109,"end":117},"obj":"VBN"},{"id":"T9277","span":{"begin":10,"end":17},"obj":"IN"},{"id":"T9278","span":{"begin":35,"end":43},"obj":"VBD"},{"id":"T9279","span":{"begin":18,"end":21},"obj":"DT"},{"id":"T9280","span":{"begin":27,"end":34},"obj":"NNS"},{"id":"T9281","span":{"begin":22,"end":26},"obj":"NN"},{"id":"T9282","span":{"begin":44,"end":46},"obj":"IN"},{"id":"T9283","span":{"begin":47,"end":57},"obj":"NN"},{"id":"T9284","span":{"begin":58,"end":60},"obj":"IN"},{"id":"T9285","span":{"begin":61,"end":64},"obj":"DT"},{"id":"T9286","span":{"begin":81,"end":88},"obj":"NNS"},{"id":"T9287","span":{"begin":65,"end":71},"obj":"NN"},{"id":"T9288","span":{"begin":72,"end":80},"obj":"NN"},{"id":"T9289","span":{"begin":88,"end":90},"obj":","},{"id":"T9290","span":{"begin":90,"end":95},"obj":"NN"},{"id":"T9291","span":{"begin":96,"end":103},"obj":"NNS"},{"id":"T9292","span":{"begin":104,"end":108},"obj":"VBD"},{"id":"T9293","span":{"begin":118,"end":121},"obj":"IN"},{"id":"T9294","span":{"begin":122,"end":125},"obj":"NN"},{"id":"T9295","span":{"begin":126,"end":129},"obj":"NN"},{"id":"T9296","span":{"begin":125,"end":126},"obj":"HYPH"},{"id":"T9297","span":{"begin":130,"end":139},"obj":"NN"},{"id":"T9298","span":{"begin":140,"end":148},"obj":"NN"},{"id":"T9299","span":{"begin":149,"end":152},"obj":"CC"},{"id":"T9300","span":{"begin":153,"end":159},"obj":"NN"},{"id":"T9301","span":{"begin":160,"end":168},"obj":"NN"},{"id":"T9302","span":{"begin":169,"end":170},"obj":"-LRB-"},{"id":"T9303","span":{"begin":177,"end":179},"obj":"NN"},{"id":"T9304","span":{"begin":170,"end":176},"obj":"NN"},{"id":"T9305","span":{"begin":179,"end":180},"obj":"-RRB-"},{"id":"T9306","span":{"begin":180,"end":181},"obj":"."},{"id":"T9307","span":{"begin":181,"end":347},"obj":"sentence"},{"id":"T9308","span":{"begin":182,"end":185},"obj":"NN"},{"id":"T9309","span":{"begin":186,"end":189},"obj":"NN"},{"id":"T9310","span":{"begin":185,"end":186},"obj":"HYPH"},{"id":"T9311","span":{"begin":190,"end":199},"obj":"NN"},{"id":"T9312","span":{"begin":200,"end":208},"obj":"NN"},{"id":"T9313","span":{"begin":213,"end":220},"obj":"VBN"},{"id":"T9314","span":{"begin":209,"end":212},"obj":"VBD"},{"id":"T9315","span":{"begin":221,"end":223},"obj":"IN"},{"id":"T9316","span":{"begin":224,"end":226},"obj":"CD"},{"id":"T9317","span":{"begin":226,"end":227},"obj":"NN"},{"id":"T9318","span":{"begin":228,"end":231},"obj":"CC"},{"id":"T9319","span":{"begin":232,"end":234},"obj":"CD"},{"id":"T9320","span":{"begin":234,"end":235},"obj":"NN"},{"id":"T9321","span":{"begin":236,"end":238},"obj":"IN"},{"id":"T9322","span":{"begin":239,"end":242},"obj":"DT"},{"id":"T9323","span":{"begin":265,"end":269},"obj":"NNS"},{"id":"T9324","span":{"begin":243,"end":248},"obj":"NN"},{"id":"T9325","span":{"begin":248,"end":249},"obj":"SYM"},{"id":"T9326","span":{"begin":249,"end":250},"obj":"HYPH"},{"id":"T9327","span":{"begin":250,"end":251},"obj":"SYM"},{"id":"T9328","span":{"begin":252,"end":255},"obj":"CC"},{"id":"T9329","span":{"begin":256,"end":261},"obj":"NN"},{"id":"T9330","span":{"begin":261,"end":262},"obj":"SYM"},{"id":"T9331","span":{"begin":262,"end":263},"obj":"HYPH"},{"id":"T9332","span":{"begin":263,"end":264},"obj":"SYM"},{"id":"T9333","span":{"begin":269,"end":271},"obj":","},{"id":"T9334","span":{"begin":271,"end":283},"obj":"RB"},{"id":"T9335","span":{"begin":284,"end":285},"obj":"-LRB-"},{"id":"T9336","span":{"begin":292,"end":294},"obj":"NN"},{"id":"T9337","span":{"begin":285,"end":291},"obj":"NN"},{"id":"T9338","span":{"begin":294,"end":295},"obj":"-RRB-"},{"id":"T9339","span":{"begin":295,"end":297},"obj":","},{"id":"T9340","span":{"begin":297,"end":300},"obj":"CC"},{"id":"T9341","span":{"begin":301,"end":305},"obj":"RB"},{"id":"T9342","span":{"begin":306,"end":315},"obj":"VBD"},{"id":"T9343","span":{"begin":316,"end":319},"obj":"DT"},{"id":"T9344","span":{"begin":320,"end":327},"obj":"NNS"},{"id":"T9345","span":{"begin":328,"end":330},"obj":"IN"},{"id":"T9346","span":{"begin":331,"end":335},"obj":"NN"},{"id":"T9347","span":{"begin":336,"end":346},"obj":"NN"},{"id":"T9348","span":{"begin":346,"end":347},"obj":"."},{"id":"T9349","span":{"begin":347,"end":516},"obj":"sentence"},{"id":"T9350","span":{"begin":348,"end":350},"obj":"IN"},{"id":"T9351","span":{"begin":488,"end":497},"obj":"VBN"},{"id":"T9352","span":{"begin":351,"end":359},"obj":"NN"},{"id":"T9353","span":{"begin":359,"end":361},"obj":","},{"id":"T9354","span":{"begin":361,"end":369},"obj":"IN"},{"id":"T9355","span":{"begin":404,"end":408},"obj":"VBD"},{"id":"T9356","span":{"begin":370,"end":373},"obj":"DT"},{"id":"T9357","span":{"begin":397,"end":403},"obj":"NNS"},{"id":"T9358","span":{"begin":374,"end":380},"obj":"NN"},{"id":"T9359","span":{"begin":381,"end":385},"obj":"NN"},{"id":"T9360","span":{"begin":386,"end":396},"obj":"NN"},{"id":"T9361","span":{"begin":409,"end":420},"obj":"RB"},{"id":"T9362","span":{"begin":421,"end":430},"obj":"JJ"},{"id":"T9363","span":{"begin":431,"end":433},"obj":"IN"},{"id":"T9364","span":{"begin":434,"end":437},"obj":"DT"},{"id":"T9365","span":{"begin":447,"end":452},"obj":"NN"},{"id":"T9366","span":{"begin":438,"end":446},"obj":"NN"},{"id":"T9367","span":{"begin":452,"end":454},"obj":","},{"id":"T9368","span":{"begin":454,"end":460},"obj":"NN"},{"id":"T9369","span":{"begin":461,"end":469},"obj":"NN"},{"id":"T9370","span":{"begin":470,"end":473},"obj":"VBD"},{"id":"T9371","span":{"begin":474,"end":487},"obj":"RB"},{"id":"T9372","span":{"begin":498,"end":500},"obj":"IN"},{"id":"T9373","span":{"begin":501,"end":503},"obj":"CD"},{"id":"T9374","span":{"begin":503,"end":504},"obj":"NN"},{"id":"T9375","span":{"begin":505,"end":506},"obj":"-LRB-"},{"id":"T9376","span":{"begin":510,"end":514},"obj":"CD"},{"id":"T9377","span":{"begin":506,"end":507},"obj":"NN"},{"id":"T9378","span":{"begin":508,"end":509},"obj":"SYM"},{"id":"T9379","span":{"begin":514,"end":515},"obj":"-RRB-"},{"id":"T9380","span":{"begin":515,"end":516},"obj":"."},{"id":"T9381","span":{"begin":516,"end":595},"obj":"sentence"},{"id":"T9382","span":{"begin":517,"end":519},"obj":"IN"},{"id":"T9383","span":{"begin":585,"end":594},"obj":"VBN"},{"id":"T9384","span":{"begin":520,"end":523},"obj":"DT"},{"id":"T9385","span":{"begin":537,"end":541},"obj":"NNS"},{"id":"T9386","span":{"begin":524,"end":536},"obj":"JJ"},{"id":"T9387","span":{"begin":541,"end":543},"obj":","},{"id":"T9388","span":{"begin":543,"end":547},"obj":"CC"},{"id":"T9389","span":{"begin":552,"end":556},"obj":"NN"},{"id":"T9390","span":{"begin":548,"end":551},"obj":"DT"},{"id":"T9391","span":{"begin":557,"end":560},"obj":"CC"},{"id":"T9392","span":{"begin":561,"end":569},"obj":"NN"},{"id":"T9393","span":{"begin":570,"end":572},"obj":"IN"},{"id":"T9394","span":{"begin":573,"end":579},"obj":"NN"},{"id":"T9395","span":{"begin":580,"end":584},"obj":"VBD"},{"id":"T9396","span":{"begin":594,"end":595},"obj":"."},{"id":"T9397","span":{"begin":595,"end":787},"obj":"sentence"},{"id":"T9398","span":{"begin":596,"end":606},"obj":"NN"},{"id":"T9399","span":{"begin":610,"end":615},"obj":"VBN"},{"id":"T9400","span":{"begin":607,"end":609},"obj":"VBZ"},{"id":"T9401","span":{"begin":616,"end":618},"obj":"TO"},{"id":"T9402","span":{"begin":619,"end":621},"obj":"VB"},{"id":"T9403","span":{"begin":622,"end":623},"obj":"DT"},{"id":"T9404","span":{"begin":643,"end":652},"obj":"NN"},{"id":"T9405","span":{"begin":624,"end":630},"obj":"JJ"},{"id":"T9406","span":{"begin":631,"end":642},"obj":"JJ"},{"id":"T9407","span":{"begin":653,"end":655},"obj":"IN"},{"id":"T9408","span":{"begin":656,"end":662},"obj":"NN"},{"id":"T9409","span":{"begin":663,"end":666},"obj":"CC"},{"id":"T9410","span":{"begin":667,"end":669},"obj":"PRP"},{"id":"T9411","span":{"begin":670,"end":672},"obj":"VBZ"},{"id":"T9412","span":{"begin":673,"end":679},"obj":"JJ"},{"id":"T9413","span":{"begin":680,"end":684},"obj":"IN"},{"id":"T9414","span":{"begin":725,"end":728},"obj":"VBP"},{"id":"T9415","span":{"begin":685,"end":688},"obj":"DT"},{"id":"T9416","span":{"begin":704,"end":711},"obj":"NNS"},{"id":"T9417","span":{"begin":689,"end":697},"obj":"JJ"},{"id":"T9418","span":{"begin":698,"end":703},"obj":"NN"},{"id":"T9419","span":{"begin":712,"end":714},"obj":"IN"},{"id":"T9420","span":{"begin":715,"end":718},"obj":"DT"},{"id":"T9421","span":{"begin":719,"end":724},"obj":"NN"},{"id":"T9422","span":{"begin":729,"end":740},"obj":"JJ"},{"id":"T9423","span":{"begin":741,"end":744},"obj":"IN"},{"id":"T9424","span":{"begin":745,"end":748},"obj":"DT"},{"id":"T9425","span":{"begin":749,"end":759},"obj":"NN"},{"id":"T9426","span":{"begin":760,"end":762},"obj":"IN"},{"id":"T9427","span":{"begin":763,"end":766},"obj":"DT"},{"id":"T9428","span":{"begin":776,"end":781},"obj":"NN"},{"id":"T9429","span":{"begin":767,"end":775},"obj":"NN"},{"id":"T9430","span":{"begin":782,"end":783},"obj":"-LRB-"},{"id":"T9431","span":{"begin":783,"end":785},"obj":"CD"},{"id":"T9432","span":{"begin":785,"end":786},"obj":"-RRB-"},{"id":"T9433","span":{"begin":786,"end":787},"obj":"."}],"relations":[{"id":"R6136","pred":"aux","subj":"T9274","obj":"T9275"},{"id":"R6137","pred":"advcl","subj":"T9275","obj":"T9276"},{"id":"R6138","pred":"mark","subj":"T9277","obj":"T9278"},{"id":"R6139","pred":"ccomp","subj":"T9278","obj":"T9275"},{"id":"R6140","pred":"det","subj":"T9279","obj":"T9280"},{"id":"R6141","pred":"nsubj","subj":"T9280","obj":"T9278"},{"id":"R6142","pred":"compound","subj":"T9281","obj":"T9280"},{"id":"R6143","pred":"prep","subj":"T9282","obj":"T9278"},{"id":"R6144","pred":"pobj","subj":"T9283","obj":"T9282"},{"id":"R6145","pred":"prep","subj":"T9284","obj":"T9283"},{"id":"R6146","pred":"det","subj":"T9285","obj":"T9286"},{"id":"R6147","pred":"pobj","subj":"T9286","obj":"T9284"},{"id":"R6148","pred":"compound","subj":"T9287","obj":"T9288"},{"id":"R6149","pred":"compound","subj":"T9288","obj":"T9286"},{"id":"R6150","pred":"punct","subj":"T9289","obj":"T9276"},{"id":"R6151","pred":"compound","subj":"T9290","obj":"T9291"},{"id":"R6152","pred":"nsubjpass","subj":"T9291","obj":"T9276"},{"id":"R6153","pred":"auxpass","subj":"T9292","obj":"T9276"},{"id":"R6154","pred":"prep","subj":"T9293","obj":"T9276"},{"id":"R6155","pred":"compound","subj":"T9294","obj":"T9295"},{"id":"R6156","pred":"compound","subj":"T9295","obj":"T9297"},{"id":"R6157","pred":"punct","subj":"T9296","obj":"T9295"},{"id":"R6158","pred":"compound","subj":"T9297","obj":"T9298"},{"id":"R6159","pred":"pobj","subj":"T9298","obj":"T9293"},{"id":"R6160","pred":"cc","subj":"T9299","obj":"T9298"},{"id":"R6161","pred":"compound","subj":"T9300","obj":"T9301"},{"id":"R6162","pred":"conj","subj":"T9301","obj":"T9298"},{"id":"R6163","pred":"punct","subj":"T9302","obj":"T9303"},{"id":"R6164","pred":"parataxis","subj":"T9303","obj":"T9276"},{"id":"R6165","pred":"compound","subj":"T9304","obj":"T9303"},{"id":"R6166","pred":"punct","subj":"T9305","obj":"T9303"},{"id":"R6167","pred":"punct","subj":"T9306","obj":"T9276"},{"id":"R6168","pred":"compound","subj":"T9308","obj":"T9309"},{"id":"R6169","pred":"compound","subj":"T9309","obj":"T9311"},{"id":"R6170","pred":"punct","subj":"T9310","obj":"T9309"},{"id":"R6171","pred":"compound","subj":"T9311","obj":"T9312"},{"id":"R6172","pred":"nsubjpass","subj":"T9312","obj":"T9313"},{"id":"R6173","pred":"auxpass","subj":"T9314","obj":"T9313"},{"id":"R6174","pred":"prep","subj":"T9315","obj":"T9313"},{"id":"R6175","pred":"nummod","subj":"T9316","obj":"T9317"},{"id":"R6176","pred":"pobj","subj":"T9317","obj":"T9315"},{"id":"R6177","pred":"cc","subj":"T9318","obj":"T9317"},{"id":"R6178","pred":"nummod","subj":"T9319","obj":"T9320"},{"id":"R6179","pred":"conj","subj":"T9320","obj":"T9317"},{"id":"R6180","pred":"prep","subj":"T9321","obj":"T9313"},{"id":"R6181","pred":"det","subj":"T9322","obj":"T9323"},{"id":"R6182","pred":"pobj","subj":"T9323","obj":"T9321"},{"id":"R6183","pred":"nmod","subj":"T9324","obj":"T9323"},{"id":"R6184","pred":"punct","subj":"T9325","obj":"T9324"},{"id":"R6185","pred":"punct","subj":"T9326","obj":"T9324"},{"id":"R6186","pred":"punct","subj":"T9327","obj":"T9324"},{"id":"R6187","pred":"cc","subj":"T9328","obj":"T9324"},{"id":"R6188","pred":"conj","subj":"T9329","obj":"T9324"},{"id":"R6189","pred":"punct","subj":"T9330","obj":"T9329"},{"id":"R6190","pred":"punct","subj":"T9331","obj":"T9329"},{"id":"R6191","pred":"punct","subj":"T9332","obj":"T9329"},{"id":"R6192","pred":"punct","subj":"T9333","obj":"T9313"},{"id":"R6193","pred":"advmod","subj":"T9334","obj":"T9313"},{"id":"R6194","pred":"punct","subj":"T9335","obj":"T9336"},{"id":"R6195","pred":"parataxis","subj":"T9336","obj":"T9313"},{"id":"R6196","pred":"compound","subj":"T9337","obj":"T9336"},{"id":"R6197","pred":"punct","subj":"T9338","obj":"T9336"},{"id":"R6198","pred":"punct","subj":"T9339","obj":"T9313"},{"id":"R6199","pred":"cc","subj":"T9340","obj":"T9313"},{"id":"R6200","pred":"advmod","subj":"T9341","obj":"T9342"},{"id":"R6201","pred":"conj","subj":"T9342","obj":"T9313"},{"id":"R6202","pred":"det","subj":"T9343","obj":"T9344"},{"id":"R6203","pred":"dobj","subj":"T9344","obj":"T9342"},{"id":"R6204","pred":"prep","subj":"T9345","obj":"T9344"},{"id":"R6205","pred":"compound","subj":"T9346","obj":"T9347"},{"id":"R6206","pred":"pobj","subj":"T9347","obj":"T9345"},{"id":"R6207","pred":"punct","subj":"T9348","obj":"T9313"},{"id":"R6208","pred":"prep","subj":"T9350","obj":"T9351"},{"id":"R6209","pred":"pobj","subj":"T9352","obj":"T9350"},{"id":"R6210","pred":"punct","subj":"T9353","obj":"T9351"},{"id":"R6211","pred":"mark","subj":"T9354","obj":"T9355"},{"id":"R6212","pred":"advcl","subj":"T9355","obj":"T9351"},{"id":"R6213","pred":"det","subj":"T9356","obj":"T9357"},{"id":"R6214","pred":"nsubj","subj":"T9357","obj":"T9355"},{"id":"R6215","pred":"compound","subj":"T9358","obj":"T9359"},{"id":"R6216","pred":"compound","subj":"T9359","obj":"T9357"},{"id":"R6217","pred":"compound","subj":"T9360","obj":"T9357"},{"id":"R6218","pred":"advmod","subj":"T9361","obj":"T9362"},{"id":"R6219","pred":"acomp","subj":"T9362","obj":"T9355"},{"id":"R6220","pred":"prep","subj":"T9363","obj":"T9355"},{"id":"R6221","pred":"det","subj":"T9364","obj":"T9365"},{"id":"R6222","pred":"pobj","subj":"T9365","obj":"T9363"},{"id":"R6223","pred":"compound","subj":"T9366","obj":"T9365"},{"id":"R6224","pred":"punct","subj":"T9367","obj":"T9351"},{"id":"R6225","pred":"compound","subj":"T9368","obj":"T9369"},{"id":"R6226","pred":"nsubjpass","subj":"T9369","obj":"T9351"},{"id":"R6227","pred":"auxpass","subj":"T9370","obj":"T9351"},{"id":"R6228","pred":"advmod","subj":"T9371","obj":"T9351"},{"id":"R6229","pred":"prep","subj":"T9372","obj":"T9351"},{"id":"R6230","pred":"nummod","subj":"T9373","obj":"T9374"},{"id":"R6231","pred":"pobj","subj":"T9374","obj":"T9372"},{"id":"R6232","pred":"punct","subj":"T9375","obj":"T9376"},{"id":"R6233","pred":"parataxis","subj":"T9376","obj":"T9351"},{"id":"R6234","pred":"nsubj","subj":"T9377","obj":"T9376"},{"id":"R6235","pred":"punct","subj":"T9378","obj":"T9376"},{"id":"R6236","pred":"punct","subj":"T9379","obj":"T9376"},{"id":"R6237","pred":"punct","subj":"T9380","obj":"T9351"},{"id":"R6238","pred":"prep","subj":"T9382","obj":"T9383"},{"id":"R6239","pred":"det","subj":"T9384","obj":"T9385"},{"id":"R6240","pred":"pobj","subj":"T9385","obj":"T9382"},{"id":"R6241","pred":"amod","subj":"T9386","obj":"T9385"},{"id":"R6242","pred":"punct","subj":"T9387","obj":"T9383"},{"id":"R6243","pred":"preconj","subj":"T9388","obj":"T9389"},{"id":"R6244","pred":"nsubjpass","subj":"T9389","obj":"T9383"},{"id":"R6245","pred":"det","subj":"T9390","obj":"T9389"},{"id":"R6246","pred":"cc","subj":"T9391","obj":"T9389"},{"id":"R6247","pred":"conj","subj":"T9392","obj":"T9389"},{"id":"R6248","pred":"prep","subj":"T9393","obj":"T9392"},{"id":"R6249","pred":"pobj","subj":"T9394","obj":"T9393"},{"id":"R6250","pred":"auxpass","subj":"T9395","obj":"T9383"},{"id":"R6251","pred":"punct","subj":"T9396","obj":"T9383"},{"id":"R6252","pred":"nsubjpass","subj":"T9398","obj":"T9399"},{"id":"R6253","pred":"auxpass","subj":"T9400","obj":"T9399"},{"id":"R6254","pred":"aux","subj":"T9401","obj":"T9402"},{"id":"R6255","pred":"xcomp","subj":"T9402","obj":"T9399"},{"id":"R6256","pred":"det","subj":"T9403","obj":"T9404"},{"id":"R6257","pred":"attr","subj":"T9404","obj":"T9402"},{"id":"R6258","pred":"amod","subj":"T9405","obj":"T9404"},{"id":"R6259","pred":"amod","subj":"T9406","obj":"T9404"},{"id":"R6260","pred":"prep","subj":"T9407","obj":"T9404"},{"id":"R6261","pred":"pobj","subj":"T9408","obj":"T9407"},{"id":"R6262","pred":"cc","subj":"T9409","obj":"T9399"},{"id":"R6263","pred":"nsubj","subj":"T9410","obj":"T9411"},{"id":"R6264","pred":"conj","subj":"T9411","obj":"T9399"},{"id":"R6265","pred":"acomp","subj":"T9412","obj":"T9411"},{"id":"R6266","pred":"mark","subj":"T9413","obj":"T9414"},{"id":"R6267","pred":"ccomp","subj":"T9414","obj":"T9411"},{"id":"R6268","pred":"det","subj":"T9415","obj":"T9416"},{"id":"R6269","pred":"nsubj","subj":"T9416","obj":"T9414"},{"id":"R6270","pred":"amod","subj":"T9417","obj":"T9416"},{"id":"R6271","pred":"compound","subj":"T9418","obj":"T9416"},{"id":"R6272","pred":"prep","subj":"T9419","obj":"T9416"},{"id":"R6273","pred":"det","subj":"T9420","obj":"T9421"},{"id":"R6274","pred":"pobj","subj":"T9421","obj":"T9419"},{"id":"R6275","pred":"acomp","subj":"T9422","obj":"T9414"},{"id":"R6276","pred":"prep","subj":"T9423","obj":"T9422"},{"id":"R6277","pred":"det","subj":"T9424","obj":"T9425"},{"id":"R6278","pred":"pobj","subj":"T9425","obj":"T9423"},{"id":"R6279","pred":"prep","subj":"T9426","obj":"T9425"},{"id":"R6280","pred":"det","subj":"T9427","obj":"T9428"},{"id":"R6281","pred":"pobj","subj":"T9428","obj":"T9426"},{"id":"R6282","pred":"compound","subj":"T9429","obj":"T9428"},{"id":"R6283","pred":"punct","subj":"T9430","obj":"T9431"},{"id":"R6284","pred":"parataxis","subj":"T9431","obj":"T9411"},{"id":"R6285","pred":"punct","subj":"T9432","obj":"T9431"},{"id":"R6286","pred":"punct","subj":"T9433","obj":"T9411"}],"text":"To verify whether the mRNA changes resulted in alteration of the enzyme activity changes, liver samples were analyzed for HMG-CoA reductase activity and Cyp7a1 activity (Figure 4b). HMG-CoA reductase activity was reduced by 30% and 60% in the Abcg8+/- and Abcg8-/- mice, respectively (Figure 4b), and thus reflected the changes in mRNA expression. In contrast, although the Cyp7a1 mRNA expression levels were essentially unchanged in the knockout mouse, Cyp7a1 activity was significantly decreased by 37% (P \u003c 0.01). In the heterozygous mice, both the mRNA and activity of Cyp7a1 were decreased. Sitosterol is known to be a direct competitive inhibitor of Cyp7a1 and it is likely that the elevated plant sterols in the liver are responsible for the inhibition in the knockout mouse [39]."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T9031","span":{"begin":22,"end":26},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T9032","span":{"begin":65,"end":71},"obj":"CHEBI_GO_SO_EXT:enzyme"},{"id":"T9033","span":{"begin":90,"end":95},"obj":"UBERON:0002107"},{"id":"T9034","span":{"begin":122,"end":129},"obj":"CHEBI:11814"},{"id":"T9035","span":{"begin":122,"end":139},"obj":"GO_PR_EXT:hydroxymethylglutaryl_CoA_reductase"},{"id":"T9036","span":{"begin":153,"end":159},"obj":"PR_EXT:000006148"},{"id":"T9037","span":{"begin":182,"end":189},"obj":"CHEBI:11814"},{"id":"T9038","span":{"begin":182,"end":199},"obj":"GO_PR_EXT:hydroxymethylglutaryl_CoA_reductase"},{"id":"T9039","span":{"begin":243,"end":248},"obj":"PR_EXT:000003573"},{"id":"T9040","span":{"begin":248,"end":249},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T9041","span":{"begin":250,"end":251},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T9042","span":{"begin":256,"end":261},"obj":"PR_EXT:000003573"},{"id":"T9043","span":{"begin":261,"end":262},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T9044","span":{"begin":263,"end":264},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T9045","span":{"begin":265,"end":269},"obj":"NCBITaxon:10088"},{"id":"T9046","span":{"begin":331,"end":335},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T9047","span":{"begin":336,"end":346},"obj":"GO:0010467"},{"id":"T9048","span":{"begin":374,"end":380},"obj":"PR_EXT:000006148"},{"id":"T9049","span":{"begin":381,"end":385},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T9050","span":{"begin":386,"end":396},"obj":"GO:0010467"},{"id":"T9051","span":{"begin":447,"end":452},"obj":"NCBITaxon:10088"},{"id":"T9052","span":{"begin":454,"end":460},"obj":"PR_EXT:000006148"},{"id":"T9053","span":{"begin":537,"end":541},"obj":"NCBITaxon:10088"},{"id":"T9054","span":{"begin":552,"end":556},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T9055","span":{"begin":573,"end":579},"obj":"PR_EXT:000006148"},{"id":"T9056","span":{"begin":596,"end":606},"obj":"CHEBI:27693"},{"id":"T9057","span":{"begin":643,"end":652},"obj":"CHEBI_EXT:35222"},{"id":"T9058","span":{"begin":656,"end":662},"obj":"PR_EXT:000006148"},{"id":"T9059","span":{"begin":698,"end":703},"obj":"NCBITaxon:3193"},{"id":"T9060","span":{"begin":704,"end":711},"obj":"CHEBI:15889"},{"id":"T9061","span":{"begin":719,"end":724},"obj":"UBERON:0002107"},{"id":"T9062","span":{"begin":776,"end":781},"obj":"NCBITaxon:10088"}],"text":"To verify whether the mRNA changes resulted in alteration of the enzyme activity changes, liver samples were analyzed for HMG-CoA reductase activity and Cyp7a1 activity (Figure 4b). HMG-CoA reductase activity was reduced by 30% and 60% in the Abcg8+/- and Abcg8-/- mice, respectively (Figure 4b), and thus reflected the changes in mRNA expression. In contrast, although the Cyp7a1 mRNA expression levels were essentially unchanged in the knockout mouse, Cyp7a1 activity was significantly decreased by 37% (P \u003c 0.01). In the heterozygous mice, both the mRNA and activity of Cyp7a1 were decreased. Sitosterol is known to be a direct competitive inhibitor of Cyp7a1 and it is likely that the elevated plant sterols in the liver are responsible for the inhibition in the knockout mouse [39]."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T8957","span":{"begin":90,"end":95},"obj":"UBERON:0002107"},{"id":"T8958","span":{"begin":122,"end":129},"obj":"CHEBI:11814"},{"id":"T8959","span":{"begin":153,"end":159},"obj":"PR:000006148"},{"id":"T8960","span":{"begin":182,"end":189},"obj":"CHEBI:11814"},{"id":"T8961","span":{"begin":243,"end":248},"obj":"PR:000003573"},{"id":"T8962","span":{"begin":256,"end":261},"obj":"PR:000003573"},{"id":"T8963","span":{"begin":265,"end":269},"obj":"NCBITaxon:10088"},{"id":"T8964","span":{"begin":336,"end":346},"obj":"GO:0010467"},{"id":"T8965","span":{"begin":374,"end":380},"obj":"PR:000006148"},{"id":"T8966","span":{"begin":386,"end":396},"obj":"GO:0010467"},{"id":"T8967","span":{"begin":447,"end":452},"obj":"NCBITaxon:10088"},{"id":"T8968","span":{"begin":454,"end":460},"obj":"PR:000006148"},{"id":"T8969","span":{"begin":537,"end":541},"obj":"NCBITaxon:10088"},{"id":"T8970","span":{"begin":573,"end":579},"obj":"PR:000006148"},{"id":"T8971","span":{"begin":596,"end":606},"obj":"CHEBI:27693"},{"id":"T8972","span":{"begin":643,"end":652},"obj":"CHEBI:35222"},{"id":"T8973","span":{"begin":656,"end":662},"obj":"PR:000006148"},{"id":"T8974","span":{"begin":698,"end":703},"obj":"NCBITaxon:3193"},{"id":"T8975","span":{"begin":704,"end":711},"obj":"CHEBI:15889"},{"id":"T8976","span":{"begin":719,"end":724},"obj":"UBERON:0002107"},{"id":"T8977","span":{"begin":776,"end":781},"obj":"NCBITaxon:10088"}],"text":"To verify whether the mRNA changes resulted in alteration of the enzyme activity changes, liver samples were analyzed for HMG-CoA reductase activity and Cyp7a1 activity (Figure 4b). HMG-CoA reductase activity was reduced by 30% and 60% in the Abcg8+/- and Abcg8-/- mice, respectively (Figure 4b), and thus reflected the changes in mRNA expression. In contrast, although the Cyp7a1 mRNA expression levels were essentially unchanged in the knockout mouse, Cyp7a1 activity was significantly decreased by 37% (P \u003c 0.01). In the heterozygous mice, both the mRNA and activity of Cyp7a1 were decreased. Sitosterol is known to be a direct competitive inhibitor of Cyp7a1 and it is likely that the elevated plant sterols in the liver are responsible for the inhibition in the knockout mouse [39]."}

{"project":"2_test","denotations":[{"id":"15040800-3143743-12037307","span":{"begin":783,"end":785},"obj":"3143743"}],"text":"To verify whether the mRNA changes resulted in alteration of the enzyme activity changes, liver samples were analyzed for HMG-CoA reductase activity and Cyp7a1 activity (Figure 4b). HMG-CoA reductase activity was reduced by 30% and 60% in the Abcg8+/- and Abcg8-/- mice, respectively (Figure 4b), and thus reflected the changes in mRNA expression. In contrast, although the Cyp7a1 mRNA expression levels were essentially unchanged in the knockout mouse, Cyp7a1 activity was significantly decreased by 37% (P \u003c 0.01). In the heterozygous mice, both the mRNA and activity of Cyp7a1 were decreased. Sitosterol is known to be a direct competitive inhibitor of Cyp7a1 and it is likely that the elevated plant sterols in the liver are responsible for the inhibition in the knockout mouse [39]."}