PMC:3925439 / 142-846 JSONTXT

{"project":"NEUROSES","denotations":[{"id":"T50","span":{"begin":608,"end":612},"obj":"PATO_0000117"},{"id":"T93","span":{"begin":222,"end":225},"obj":"PATO_0000011"},{"id":"T94","span":{"begin":222,"end":225},"obj":"CHEBI_84123"},{"id":"T38","span":{"begin":222,"end":225},"obj":"PATO_0000011"},{"id":"T39","span":{"begin":222,"end":225},"obj":"CHEBI_84123"},{"id":"T40","span":{"begin":435,"end":438},"obj":"CHEBI_29447"},{"id":"T41","span":{"begin":542,"end":545},"obj":"CHEBI_29447"},{"id":"T42","span":{"begin":435,"end":438},"obj":"CHEBI_29426"},{"id":"T43","span":{"begin":542,"end":545},"obj":"CHEBI_29426"},{"id":"T44","span":{"begin":435,"end":438},"obj":"CHEBI_29441"},{"id":"T45","span":{"begin":542,"end":545},"obj":"CHEBI_29441"},{"id":"T46","span":{"begin":435,"end":438},"obj":"CHEBI_18022"},{"id":"T47","span":{"begin":542,"end":545},"obj":"CHEBI_18022"},{"id":"T48","span":{"begin":435,"end":438},"obj":"CHEBI_29425"},{"id":"T49","span":{"begin":542,"end":545},"obj":"CHEBI_29425"}],"text":"Background\nIn 2006 there were 432,700 people in Australia who had acquired brain injury (ABI) with some limitation of activities; 90% of these were traumatic brain injuries (TBIs) and nearly a third sustained injury below age 15 years. One to four years post injury, 20% to 46% of children with traumatic brain injury (TBI) have clinically significant disorders of attention. There is controversy as to whether central nervous system (CNS) stimulants can be an effective method of treating these.\nObjectives were to determine the efficacy of CNS stimulants for children with TBI, and to calculate the sample size for a larger trial using the Conners’ 3 Parent Rating Scales Score as the primary endpoint."}