PMC:3897848 / 16895-18811
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3897848","sourcedb":"PMC","sourceid":"3897848","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3897848","text":"Studies Using Biospecimens of Biobanks\nIn 2000, following the HGP, biological research moved into the so-called genomic era. Diseases have been studied by identifying genes and their specific function and understanding the role played by genetics in the beginning and prognosis of diseases, and an advanced world of medicine, known as \"personalized medicine,\" has been initiated [5].\nAccessibility to human specimens and data for the purposes of research is important for realms, such as genomics, proteomics, metabolomics, molecular imaging, and nanotechnology [23]. There are genetic factors that affect susceptibility to common diseases [24]. These diseases may have several genetic risk factors that influence each other, and interact with the environment, and this has spurred the development of large-scale biobanking projects to identify susceptible genes [25].\nDespite intensive research over the last decade, most of the genetic basis of common human diseases remains unknown. The identification of meaningful genetic variants, genes, and pathways involved in special diseases offers a potential route to new therapies, improved diagnosis, and better disease prevention. For some time, it has been hoped that the advent of GWASs would provide a successful new tool for solving the genetic basis of many of these common causes of human morbidity and mortality.\nAdvances in sequencing technology enabled us to sequence the whole human genome [26, 27]. The use of WGS of large patient cohorts is a much-needed approach in researching complex traits; it is still being ruled out to detect low-frequency genetic variants, due to its high costs [28, 29].\nAmong the new and emerging fields of research is proteomics, the study of the full set of proteins encoded by the genome. Also, proteomics is strongly associated with the discovery phase, the first step in the process chain to create diagnostic content [30].","divisions":[{"label":"Title","span":{"begin":0,"end":38}}],"tracks":[{"project":"2_test","denotations":[{"id":"24465232-17554300-44840004","span":{"begin":864,"end":866},"obj":"17554300"},{"id":"24465232-12748437-44840005","span":{"begin":1450,"end":1452},"obj":"12748437"},{"id":"24465232-21155765-44840006","span":{"begin":1649,"end":1651},"obj":"21155765"},{"id":"24465232-19855095-44840007","span":{"begin":1653,"end":1655},"obj":"19855095"},{"id":"24465232-16546995-44840008","span":{"begin":1912,"end":1914},"obj":"16546995"}],"attributes":[{"subj":"24465232-17554300-44840004","pred":"source","obj":"2_test"},{"subj":"24465232-12748437-44840005","pred":"source","obj":"2_test"},{"subj":"24465232-21155765-44840006","pred":"source","obj":"2_test"},{"subj":"24465232-19855095-44840007","pred":"source","obj":"2_test"},{"subj":"24465232-16546995-44840008","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ce93ec","default":true}]}]}}