PMC:3839092 / 27521-29529 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3839092","sourcedb":"PMC","sourceid":"3839092","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3839092","text":"Anhedonia and WM integrity\nThe dimensional analysis with anhedonia revealed an association between increased anhedonia and reduced integrity in the anterior limb of the internal capsule near the thalamus, a tract implicated in reward processing (19). The anterior limb of the internal capsule connects the thalamus with cingulate and prefrontal cortices, which are heavily involved in motivation, decision-making, and evaluating the saliency of emotional and rewarding stimuli. Additionally, increased anhedonia was correlated with reduced integrity in tracts (i.e., IFOF, projection fibers) connected to the posterior lateral OFC (BA 47), an area involved in many functions including emotional and reward processing, complex learning, and the inhibition of responses (46, 47, 55). Depressed patients have demonstrated reduced gray matter volume in the posterior lateral OFC as well as altered functional responses to emotional stimuli, reward processing, and reversal learning (56).\nWe also found reduced integrity in the external capsule as anhedonia increased. The external capsule contains cholinergic fibers projecting from the basal forebrain to the cerebral cortex. Reduced integrity in the external capsule has been found previously in adult MDD (57, 58). Furthermore, we once again found reduced integrity in the previously discussed sagittal stratum and posterior cingulum near the precuneus with greater symptom severity. Finally, the analysis revealed increased integrity with increased anhedonia in the posterior cingulum near the hippocampus, in an area fairly close to the cluster that showed increased integrity in the MDD group in our categorical comparison. In this way, it is possible that anhedonic symptoms are related to the group differences we observed. Given the previously discussed role of the hippocampus and limbic system in the regulation of motivation and emotion, the relationship between hippocampal functioning and anhedonia represents an important area for future research.","divisions":[{"label":"Title","span":{"begin":0,"end":26}}],"tracks":[{"project":"2_test","denotations":[{"id":"24324445-23616433-41737798","span":{"begin":246,"end":248},"obj":"23616433"},{"id":"24324445-16552413-41737799","span":{"begin":769,"end":771},"obj":"16552413"},{"id":"24324445-10731225-41737800","span":{"begin":773,"end":775},"obj":"10731225"},{"id":"24324445-17872395-41737801","span":{"begin":979,"end":981},"obj":"17872395"},{"id":"24324445-21170955-41737802","span":{"begin":1255,"end":1257},"obj":"21170955"},{"id":"24324445-22721700-41737803","span":{"begin":1259,"end":1261},"obj":"22721700"}],"attributes":[{"subj":"24324445-23616433-41737798","pred":"source","obj":"2_test"},{"subj":"24324445-16552413-41737799","pred":"source","obj":"2_test"},{"subj":"24324445-10731225-41737800","pred":"source","obj":"2_test"},{"subj":"24324445-17872395-41737801","pred":"source","obj":"2_test"},{"subj":"24324445-21170955-41737802","pred":"source","obj":"2_test"},{"subj":"24324445-22721700-41737803","pred":"source","obj":"2_test"}]},{"project":"NEUROSES","denotations":[{"id":"T556","span":{"begin":99,"end":108},"obj":"PATO_0000470"},{"id":"T557","span":{"begin":492,"end":501},"obj":"PATO_0000470"},{"id":"T558","span":{"begin":1053,"end":1062},"obj":"PATO_0000470"},{"id":"T559","span":{"begin":1464,"end":1473},"obj":"PATO_0000470"},{"id":"T560","span":{"begin":1489,"end":1498},"obj":"PATO_0000470"},{"id":"T561","span":{"begin":1608,"end":1617},"obj":"PATO_0000470"},{"id":"T562","span":{"begin":123,"end":130},"obj":"PATO_0001997"},{"id":"T563","span":{"begin":532,"end":539},"obj":"PATO_0001997"},{"id":"T564","span":{"begin":819,"end":826},"obj":"PATO_0001997"},{"id":"T565","span":{"begin":998,"end":1005},"obj":"PATO_0001997"},{"id":"T566","span":{"begin":1173,"end":1180},"obj":"PATO_0001997"},{"id":"T567","span":{"begin":619,"end":626},"obj":"PATO_0001193"},{"id":"T568","span":{"begin":863,"end":870},"obj":"PATO_0001193"},{"id":"T569","span":{"begin":643,"end":647},"obj":"PATO_0001323"},{"id":"T570","span":{"begin":1563,"end":1567},"obj":"PATO_0001323"},{"id":"T571","span":{"begin":1983,"end":1987},"obj":"PATO_0001323"},{"id":"T572","span":{"begin":718,"end":725},"obj":"PATO_0001504"},{"id":"T573","span":{"begin":726,"end":734},"obj":"PATO_0000200"},{"id":"T574","span":{"begin":969,"end":977},"obj":"PATO_0000200"},{"id":"T575","span":{"begin":839,"end":845},"obj":"PATO_0000918"},{"id":"T576","span":{"begin":894,"end":904},"obj":"PATO_0001510"},{"id":"T577","span":{"begin":1250,"end":1253},"obj":"CHEBI_566274"},{"id":"T578","span":{"begin":1635,"end":1638},"obj":"CHEBI_566274"},{"id":"T579","span":{"begin":1588,"end":1595},"obj":"CHEBI_33731"},{"id":"T580","span":{"begin":1639,"end":1644},"obj":"CHEBI_24433"},{"id":"T581","span":{"begin":1747,"end":1752},"obj":"CHEBI_24433"},{"id":"T582","span":{"begin":1809,"end":1813},"obj":"CHEBI_50906"},{"id":"T583","span":{"begin":1858,"end":1868},"obj":"PATO_0000076"}],"attributes":[{"subj":"T556","pred":"source","obj":"NEUROSES"},{"subj":"T557","pred":"source","obj":"NEUROSES"},{"subj":"T558","pred":"source","obj":"NEUROSES"},{"subj":"T559","pred":"source","obj":"NEUROSES"},{"subj":"T560","pred":"source","obj":"NEUROSES"},{"subj":"T561","pred":"source","obj":"NEUROSES"},{"subj":"T562","pred":"source","obj":"NEUROSES"},{"subj":"T563","pred":"source","obj":"NEUROSES"},{"subj":"T564","pred":"source","obj":"NEUROSES"},{"subj":"T565","pred":"source","obj":"NEUROSES"},{"subj":"T566","pred":"source","obj":"NEUROSES"},{"subj":"T567","pred":"source","obj":"NEUROSES"},{"subj":"T568","pred":"source","obj":"NEUROSES"},{"subj":"T569","pred":"source","obj":"NEUROSES"},{"subj":"T570","pred":"source","obj":"NEUROSES"},{"subj":"T571","pred":"source","obj":"NEUROSES"},{"subj":"T572","pred":"source","obj":"NEUROSES"},{"subj":"T573","pred":"source","obj":"NEUROSES"},{"subj":"T574","pred":"source","obj":"NEUROSES"},{"subj":"T575","pred":"source","obj":"NEUROSES"},{"subj":"T576","pred":"source","obj":"NEUROSES"},{"subj":"T577","pred":"source","obj":"NEUROSES"},{"subj":"T578","pred":"source","obj":"NEUROSES"},{"subj":"T579","pred":"source","obj":"NEUROSES"},{"subj":"T580","pred":"source","obj":"NEUROSES"},{"subj":"T581","pred":"source","obj":"NEUROSES"},{"subj":"T582","pred":"source","obj":"NEUROSES"},{"subj":"T583","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecb9","default":true},{"id":"NEUROSES","color":"#ec9e93"}]}]}}