PMC:3839092 / 16069-18046 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3839092","sourcedb":"PMC","sourceid":"3839092","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3839092","text":"Whole-brain correlations with depression severity in MDD\nExploratory analyses revealed a total of 16 uncorrected clusters, with 5 overlapping clusters between the 4 diffusivity measures (Table 3, Figure 2). As depression severity increased, FA decreased in the genu of the corpus callosum, the sagittal stratum, the ATR, and the anterior cingulum. Additionally, a positive correlation between MD and depression severity was found in the same sagittal stratum cluster as the FA analysis, as well as in clusters in the ATR and corticospinal tract. Similarly, illness severity was positively correlated with RD in the same sagittal stratum cluster as the FA and MD analyses, the same genu of the corpus callosum and ATR clusters as the FA analysis, the same ATR cluster as the MD analysis, and a cluster in the superior longitudinal fasciculus (SLF). Finally, increased illness severity was associated with increased AD in the same corticospinal cluster as the MD analysis as well as in clusters in the inferior-fronto-occipital fasciculus (IFOF), the SLF, and fibers projecting to the orbitofrontal cortex (OFC).\nTable 3 Voxel-wise correlations with depression severity (CDRS-R). Coordinates in MNI space. Threshold p \u003c 0.001, uncorrected, k \u003e 10. COG, center of gravity; L, left; R, right; FA, fractional anisotropy; MD, mean diffusivity; RD, radial diffusivity; AD, axial diffusivity; WM, white matter; PHG, parahippocampal gyrus; ACC, anterior cingulate cortex; MFG, medial frontal gyrus; OFC, orbitofrontal gyrus; ILF; inferior longitudinal fasciculus; IFOF, inferior-fronto-occipital fasciculus; ATR, anterior thalamic radiation; SLF, superior longitudinal fasciculus.\nFigure 2 Decreased WM integrity as depression severity increased in the (A) sagittal stratum near the PHG; (B) ATR near the pallidum; (C) genu of the corpus callosum and anterior cingulate; (D) anterior cingulate near the precuneus. Key: PHG, parahippocampal gyrus; ATR, anterior thalamic radiation.\n\nW","divisions":[{"label":"Title","span":{"begin":0,"end":56}},{"label":"Table caption","span":{"begin":1111,"end":1674}},{"label":"Figure caption","span":{"begin":1674,"end":1976}}],"tracks":[]}