PMC:3832756 / 25187-25934 JSONTXT

{"project":"2_test","denotations":[{"id":"23389114-22640870-29182902","span":{"begin":414,"end":416},"obj":"22640870"},{"id":"23389114-20944112-29182903","span":{"begin":674,"end":676},"obj":"20944112"},{"id":"23389114-16740722-29182904","span":{"begin":702,"end":704},"obj":"16740722"}],"text":"Here, we show that SFN, isothiocyanate present in edible plants, targets the pro-survival pathway in breast cancer cells in at least two levels: Akt activation, determined as a drop in phosphorylation in the position crucial for the kinase activity, and mTOR-S6K1 signaling, determined as a decrease in S6K1 phosphorylation in the position recognized by mTOR (Fig. 4). Inhibition of protein synthesis (Fig. 5 and [30]) and induction of autophagy (Figs. 2, 3), both controlled by mTOR, confirm that SFN inhibits this pathway. We did not explore here the role of autophagy in the response of breast cancer cells to SFN. Even if it plays protective role such as in MDA MB 231 [31] or prostate PC-3 cells [27], it delays but not suppresses cell death."}

{"project":"MyTest","denotations":[{"id":"23389114-22640870-29182902","span":{"begin":414,"end":416},"obj":"22640870"},{"id":"23389114-20944112-29182903","span":{"begin":674,"end":676},"obj":"20944112"},{"id":"23389114-16740722-29182904","span":{"begin":702,"end":704},"obj":"16740722"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Here, we show that SFN, isothiocyanate present in edible plants, targets the pro-survival pathway in breast cancer cells in at least two levels: Akt activation, determined as a drop in phosphorylation in the position crucial for the kinase activity, and mTOR-S6K1 signaling, determined as a decrease in S6K1 phosphorylation in the position recognized by mTOR (Fig. 4). Inhibition of protein synthesis (Fig. 5 and [30]) and induction of autophagy (Figs. 2, 3), both controlled by mTOR, confirm that SFN inhibits this pathway. We did not explore here the role of autophagy in the response of breast cancer cells to SFN. Even if it plays protective role such as in MDA MB 231 [31] or prostate PC-3 cells [27], it delays but not suppresses cell death."}