PMC:3813744 / 25324-27716 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3813744","sourcedb":"PMC","sourceid":"3813744","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3813744","text":"Experiment 2: Effect of 5-HT2cR KO on Egocentric Reversal Learning\nThere were no effects of genotype on probe-trials to criterion (Grand mean = 1.4±0.06). No animals failed to complete the initial spatial discrimination or the learned non-reward test. However significantly more 5-HT2CR KO animals (N = 8) than WT animals (N = 2) failed to complete either the full reversal or perseverance tests (Table 3; χ2 = 7.53, p\u003c.01).\n10.1371/journal.pone.0077762.t003 Table 3 Proportion (%) of WT and 5-HT2CR KO mice reaching criterion in egocentric discrimination, full reversal, perseverance and learned non-reward tests. Significantly fewer 5-HT2CR KO animals than WT animals reached criterion in the perseverance condition (x2 = 4.2, p = .04). 5-HT2CR KO animals required more trials to criterion (F1,31 = 6.08, p\u003c.05) and made more incorrect responses to criterion (F1,31 = 6.11, p\u003c.05) in egocentric discrimination learning (Table 1). There was also a non-significant trend for 5-HT2CR KO animals to perform worse in the full reversal test by requiring more trials (F1,31 = 3.96, p = ns) and making more incorrect responses to criterion (Fig. 2C, D; F1,31 = 3.74, p = ns).\nIn the perseverance test, there was a significant effect of genotype on trials (F1,26 = 5.83, p\u003c.05) and incorrect responses to criterion (F1,26 = 4.45, p\u003c.05) with 5-HT2CR KO mice showing retarded learning relative to WTs. Although 5-HT2CR KO mice tended to perform better than WTs in the learned non-reward test, these differences were non-significant. There were no significant effects of genotype on early and late errors to criterion (p\u003e.05; Table 2).\nTo further explore if the performance in the full reversal and perseverance tests could be accounted for by differences in initial discrimination learning, the data for these two test conditions were re-analysed using the initial spatial discrimination performance as a covariate. The near-significant effects of genotype on trials (Fig. 2C) and incorrect responses (Fig. 2D) to criterion in the full reversal test could be accounted for by retarded egocentric discrimination learning (trials, F1,30 = 0.64, p = .43; incorrect responses, F1,30 = 0.57, p = .46). However, the effect of genotype on performance in the perseverance test (Fig. 2C, D) remained statistically significant (trials, F1,25 = 7.65, p = .01; incorrect responses, F1,25 = 4.23, p = .05).","divisions":[{"label":"Title","span":{"begin":0,"end":66}},{"label":"Table caption","span":{"begin":425,"end":745}},{"label":"Title","span":{"begin":468,"end":615}}],"tracks":[]}