PMC:3762851 / 58503-62623 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3762851","sourcedb":"PMC","sourceid":"3762851","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3762851","text":"Table 6 Concentrations of metabolites in human urine as measured by GC-MS.\nCompounds Observed Concentration(µM/mM creatinine) Literature Values(µM/mM creatinine)\n2,4-Dihydroxybutanoic acid 1.0 (0.3–1.8) 2.0±2.0\n2-Ethylhydracrylic acid 2.1 (1.3–2.9) NA**\n2-Furoylglycine 3.6 (0.7–5.8) 9.95 (2.0–18.66)\n2-Hydroxy-2-methylbutyric acid 0.8 (0.4–1.5) 2.8±1.5\n2-Methyl-3-hydroxybutyric acid 4.0 (1.3–6.2) 5.5 (0.0–11.0)\n3,4-Dihydroxybenzeneacetic acid 0.9 (0.6–1.3) 1.16±0.50\n3,4-Dihydroxybutanoic acid 42.2 (21.9–56.1) 34.9 (12.5–57.2)\n3-Aminoisobutanoic acid 25.8 (1.4–155.6) 2.91–116.43\n3-Hydroxyhippuric acid 6.1 (4.1–7.8) 2.5 (0.2–5.0)\n3-Hydroxyisobutyric acid 29.0 (11.8–59.8) 17.5 (2.0–33.0)\n3-Hydroxyisovaleric acid 7.4 (4.1–17.2) 8.5±3.2\n3-Hydroxymethylglutaric acid 3.2 (1.1–5.2) 3 (0–10)\n3-Hydroxyphenylacetic acid 5.6 (1.4–15.0) 6.1±4.1\n3-Hydroxysebacic acid 2.9 (1.7–3.8) NA**\n3-Methyladipic acid 2.1 (0.9–5.6) 2.9 (0.7–10.5)\n3-Methylglutaconic acid 6.2 (2.8–8.3) 4.5 (0.0–9.0)\n4-Deoxythreonic acid 18.2 (5.6–23.9) 25±10\n4-Hydroxybenzoic acid 2.4 (1.3–3.6) 1.8±1.8\n4-Hydroxyphenyllactic acid 2.8 (2.6–3.0) 1.1 (0.2–2.6)\n5-Hydroxyhexanoic acid 2.7 (0.8–5.7) 3.5 (0.0–7.0)\n5-Hydroxyindoleacetic acid 2.9 (0.4–5.8) 2.4±0.40\nAdipic acid 3.0 (1.0–12.9) 5.1 (0.8–35.0)\nAlpha-Hydroxyisobutyric acid 2.9 (1.3–4.6) 3.8\nAzelaic acid 1.9 (1.2–3.2) 4.8 (1.3–15.0)\nBenzoic acid 3.6 (1.4–7.5) 4.2 (1.9–6.5)\nCholenic acid 0.015 (0.004–0.030) NA**\nCis/Trans-Aconitic acid 15.3 (5.2–21.8) NA**\nCitraconic acid 1.6 (0.9–2.1) 2.2\nCreatinine* 12,246±8,369 10,090±310\nDeoxycholic acid 0.055 (0.050–0.060) NA**\nD-Galactose 3.3 (1.3–8.5) 4.4 (0.0–31.0)\nD-Glucose 35.6 (10.3–56.7) 31.12\nD-Xylitol 2.3 (0.9–8.2) 3.50±2. 37\nD-Xylulose 19.7 (6.4–32.6) NA**\nEthylmalonic acid 2.4 (0.9–4.0) 2.0 (0.5–3.9)\nGluconic acid 13.3 (8.2–26.4) NA**\nGlutaric acid 1.4 (0.5–2.3 ) 1.3 (0.6–2.6)\nGlyceric acid 14.4 (7.8–28.8) 4.5 (0.0–9.0)\nGlycine 75.7 (21–205) 151 (233–248)\nGlycolic acid 39.4 (2.9–78.1) 35 (18–55)\nHippuric acid 217 (28–610) 257 (20–770)\nHomovanillic acid 4.3 (0.9–8.9) 4.9±3.4\nHPHPA 4.2 (0.9–15.3) 0.55–54.93\nHydroxypropionic acid 8.1 (3.1–11.8) 6.5 (3.0–10.0)\nIndoleacetic acid 2.6 (0.6–5.4) 2.0±1.0\nIndolelactic acid 0.9 0.460 (0.098–0.980)\nIsocitric acid 56.8 (19.4–119.1) 58 (36–84)\nKynurenic acid 2.6 (0.9–4.1) 1.34±0.30\nL-Arabinose 8.8 (0.8–19.4) 8.75 (6.12–11.84)\nL-Asparagine 9.5 (3.0–26.0) 10.0 (4.6–16.3)\nLevulinic acid 1.7 (0.6–2.5) 1.28 (0.33–2.75)\nLithocholic acid 0.16 (0.10–0.20) NA**\nL-Lactic acid 7.1 (0.9–16.4) 12.3±6.2\nL-Ornithine 5.3 (2.0–8.8) 5.0 (2.0–8.0)\nL-Phenylalanine 7.8 (5.0–11.3) 4.50±1.15\nL-Serine 19.0 (10.4–35.8) 26.0±10.0\nL-Tyrosine 15.1 (6.1–23.2) 8.8±4.5\nL-Valine 5.5 (2.7–9.8) 3.0±1.0\nMalonic acid 2.3 (1.2–3.1) 1 (0–2)\nm-Chlorobenzoic acid 0.7 NA**\nMethylmalonic acid 1.3 (0.5–2.1) 1.6 (0.0–3.6)\nMethylsuccinic acid 4.7 (1.1–6.2) 2.3 (0.8–10.8)\nMyoinositol 12.6 (5.1–15.3) 18.8±2.9\no-Hydroxyphenylacetic acid 2.9 (1.4–3.7) 7.71±3.65\nOxalic acid 8.2 (3.9–14.0) 1.11–33.34\nOxoglutaric acid 3.4 (1.4–12.5) 2.98 (0.42–18.30)\nPalmitic acid 6.7 (2.6–24.3) 11 (6–23)\nPhosphoric acid 784 (425–1170) 1000–4900\np-Hydroxyphenylacetic acid 6.0 (2.4–9.7) 9.68\nPimelic acid 1.9 (0.5–3.5) NA**\nPseudouridine 29.8 (21.8–47.3) 26.02±4.62\nPyroglutamic acid 18.6 (4.5–24.9) 28.8 (3.4–54.2)\nPyruvic acid 2.1 (1.0–3.7) 2.13 (0.54–8.67)\nQuinolinic acid 3.9 (0.9–15.1) 2.5±1.1\nScyllitol 3.6 (1.9–6.9) NA\nSorbitol 3.9 (1.9–5.1) 3.50±2.24\nStearic acid 3.9 (2.3–7.7) 2.9 (1.6–6.6)\nSuberic acid 1.2 (0.5–1.9) 0.5 (0.0–2.9)\nSuccinic acid 6.2 (2.5–13.5) 5.6±3.8\nSumiki’s acid 1.6 NA**\nThreonic acid 14.8 (8.6–36.1) 10.0±7.0\nTrans-Ferulic acid 1 36.3±11.2\nUric acid 186 (93–329) 188 (79–296)\nUrsodeoxycholic acid 0.022 (0.013–0.030) NA**\nVanillylmandelic acid 1.6 (0.6–2.8) 1.2±0.5\n* Concentration of metabolite (Mean ± SD) is expressed by µM. HPHPA: 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid; NA: not available; NA**: not available for healthy 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