PMC:3750932 / 20512-21195 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3750932","sourcedb":"PMC","sourceid":"3750932","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3750932","text":"Group 5.1 Hematologic disorders \nPH has been reported in chronic myeloproliferative disorders including polycythemia vera, essential thrombocythemia, and chronic myeloid leukemia [79,80]. Several mechanisms may be implicated in PH associated with chronic myeloproliferative disorders including high cardiac output, asplenia, direct obstruction of pulmonary arteries by circulating megakaryocytes [81], CTEPH [82], portal PH, and congestive heart failure. Splenectomy as a result of trauma or as a treatment for hematologic disorders may increase the risk of developing PH [83]. As described above, dasatinib use may be one cause of PAH, particularly in chronic myeloid leukemia 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