PMC:3730145 / 22894-23775 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/3730145","sourcedb":"PMC","sourceid":"3730145","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3730145","text":"3. Conclusions\nIn conclusion, spontaneous animal tumor models may serve an important role in translating research findings to facilitate clinical improvements in human cancer patients. Spontaneously occurring cancer in pets shares striking molecular and clinical similarities to human malignancies that cannot be reproduced in artificially induced laboratory models. Human HNSCC is one type of cancer that has suffered from limited improvement in effective therapies and outcomes in the last few decades. Given the similarities in clinical progression and therapy as well as tumor biology including EGFR signaling, molecular aspects of cancer progression and angiogenesis, and clinical manifestations of malignant osteolysis, FOSCC is a biologically relevant animal tumor model. Utilization of this naturally occurring cancer may benefit both veterinary and human cancer patients. ","divisions":[{"label":"Title","span":{"begin":0,"end":14}}],"tracks":[]}