PMC:3727988 / 814-1769 JSONTXT

{"project":"2_test","denotations":[{"id":"23815568-19769441-60544987","span":{"begin":952,"end":953},"obj":"19769441"}],"text":"This strategy is made possible by the shift from a hierarchical to a holistic vision of the biological system. In the first case the control of the biological system is generated from the genome up to the lower hierarchical levels represented by proteomics and metabolomics; in the second case, the interactions among these disciplines are evaluated in a synergic way (Figure 1). This new approach is certainly the most appropriate for the understanding of the physiopathology of migraine that, as a multifactorial disease, can only be assessed through the integrated study of the omics sciences. Nowadays, it is evident that migraine patients react differently to given drugs, but the exact mechanism has not yet been clarified. In this way, genomic and proteomic research aimed to the identification of molecular pathways involved in drug action is of pivotal importance, in order to focus attention of pharmacogenomics studies on the right targets [1]."}