PMC:3727988 / 14449-15355 JSONTXT

{"project":"2_test","denotations":[{"id":"23815568-22447836-60545023","span":{"begin":305,"end":307},"obj":"22447836"},{"id":"23815568-15670679-60545024","span":{"begin":462,"end":464},"obj":"15670679"},{"id":"23815568-21301922-60545025","span":{"begin":579,"end":581},"obj":"21301922"},{"id":"23815568-15728280-60545026","span":{"begin":619,"end":621},"obj":"15728280"},{"id":"23815568-22527035-60545027","span":{"begin":797,"end":799},"obj":"22527035"}],"text":"However, NMR or mass spectrometry techniques are able to provide, with an acceptable probability, the description of the current biochemical state of an organism. The development of proton magnetic resonance spectroscopy (1H-MRS) has been used to assess noninvasively the metabolic status of human brain [43]. Several studies have employed 1H-MRS achieving numerous results for metabolites including N-acetylaspartate (NAA), as a marker of neuronal functioning [44], choline (Cho), as a marker for membrane turnover [45], total creatine (tCr) and lactate, for energy metabolism [46], and myo-inositol (a glial marker) [47]. With the exception of NAA, the results obtained for these molecules are heterogeneous and sometimes contradictory. Indeed the levels of NAA are also increased in the serum [48]. In our opinion, to date, it has not been identified molecules that can be used as a marker for migraine."}