PMC:3727988 / 10237-11885
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3727988","sourcedb":"PMC","sourceid":"3727988","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3727988","text":"In this regard, Bellei and co-authors reported two proteomic studies in which they analysed the urinary proteome of medication-overuse headache (MOH) patients, in comparison with healthy non-abuser individuals as control, with the purpose to identify possible differences in excreted proteins induced by the excessive consumption of antimigraine drugs, that could lead to nephrotoxicity [25,26]. Comparing the proteomic profiles of patients and controls, they found a significantly different protein expression at various MW levels, especially in the NSAIDs group, in which six proteins over-secreted from kidney were strongly correlated with various forms of kidney disorders: uromodulin (UROM), alpha-1-microglobulin (AMBP), zinc-alpha-2-glycoprotein (ZAZG), cystatin C (CYTC), Ig-kappa-chain (IGKC), and inter-alpha-trypsin heavy chain H4 (ITIH4). These preliminary results have allowed to define the urinary protein pattern of MOH patients, that was found to be correlated to the abused drug. While adverse effects from long-term triptans use are unknown, the overuse of analgesics may cause well-known unwanted events, including liver dysfunction, gastrointestinal bleeding, addiction and renal insufficiency [27]. Moreover, a recent review concerning the epidemiology of drug-induced disorders has demonstrated that medication overuse could lead to nephrotoxicity and potential renal damage [28]. Currently, the most pertinent application in nephrotoxicology is the proteomic analysis of urine. In recent years, it has proposed a broad range of urinary enzymes and proteins as possible early biomarkers of drug-induced nephrotoxicity [29-31].","tracks":[{"project":"2_test","denotations":[{"id":"23815568-21997203-60545008","span":{"begin":388,"end":390},"obj":"21997203"},{"id":"23815568-23565828-60545009","span":{"begin":391,"end":393},"obj":"23565828"},{"id":"23815568-14756859-60545010","span":{"begin":1215,"end":1217},"obj":"14756859"},{"id":"23815568-18983215-60545011","span":{"begin":1398,"end":1400},"obj":"18983215"},{"id":"23815568-16942764-60545012","span":{"begin":1641,"end":1643},"obj":"16942764"},{"id":"23815568-18282485-60545012","span":{"begin":1641,"end":1643},"obj":"18282485"}],"attributes":[{"subj":"23815568-21997203-60545008","pred":"source","obj":"2_test"},{"subj":"23815568-23565828-60545009","pred":"source","obj":"2_test"},{"subj":"23815568-14756859-60545010","pred":"source","obj":"2_test"},{"subj":"23815568-18983215-60545011","pred":"source","obj":"2_test"},{"subj":"23815568-16942764-60545012","pred":"source","obj":"2_test"},{"subj":"23815568-18282485-60545012","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec9399","default":true}]}]}}