PMC:3727638 / 92286-93554 JSONTXT

{"project":"2_test","denotations":[{"id":"23645327-16997566-110623921","span":{"begin":1251,"end":1253},"obj":"16997566"},{"id":"23645327-16997566-110623921","span":{"begin":1251,"end":1253},"obj":"16997566"},{"id":"23645327-17940620-110623922","span":{"begin":1254,"end":1256},"obj":"17940620"},{"id":"23645327-17940620-110623922","span":{"begin":1254,"end":1256},"obj":"17940620"},{"id":"23645327-18798544-110623923","span":{"begin":1257,"end":1260},"obj":"18798544"},{"id":"23645327-18798544-110623923","span":{"begin":1257,"end":1260},"obj":"18798544"},{"id":"23645327-20833329-110623924","span":{"begin":1261,"end":1264},"obj":"20833329"},{"id":"23645327-20833329-110623924","span":{"begin":1261,"end":1264},"obj":"20833329"},{"id":"23645327-16997566-68447376","span":{"begin":1251,"end":1253},"obj":"16997566"},{"id":"23645327-16997566-68447376","span":{"begin":1251,"end":1253},"obj":"16997566"},{"id":"23645327-17940620-68447377","span":{"begin":1254,"end":1256},"obj":"17940620"},{"id":"23645327-17940620-68447377","span":{"begin":1254,"end":1256},"obj":"17940620"},{"id":"23645327-18798544-68447378","span":{"begin":1257,"end":1260},"obj":"18798544"},{"id":"23645327-18798544-68447378","span":{"begin":1257,"end":1260},"obj":"18798544"}],"text":"We attempted to identify prognostic factors for overall survival in the NIH patients, and for survival from an MEN1-related death in both groups of patients in our study (the NIH and the pooled literature groups). We analyzed overall survival in addition to MEN1 disease-related survival for a number of reasons. In the literature almost all studies on prognosis in MEN1 patients report overall survival, and therefore, to allow comparison we also included overall survival. Second, by including overall survival, MEN1’s effect on all disease processes leading to death can be reviewed. This is an important point because at present there is little information on what is now described as non-MEN1-related deaths and it is unknown whether MEN1 patients have increased occurrences of any of the diseases currently included in this category. Although the exact role of menin, the protein altered in patients with MEN1, in causing many of the abnormalities seen in MEN1 patients is not known, it is clear that it is involved in many important cellular processes such as cell cycle regulation, transcriptional control, cell division, and genomic stability, any of which if altered could lead to many different diseases, including various common neoplasms.16,50,195,419,469"}