PMC:3727638 / 76084-77304 JSONTXT

{"project":"2_test","denotations":[{"id":"23645327-9922308-110623632","span":{"begin":229,"end":231},"obj":"9922308"},{"id":"23645327-9922308-110623632","span":{"begin":229,"end":231},"obj":"9922308"},{"id":"23645327-11038219-110623633","span":{"begin":232,"end":234},"obj":"11038219"},{"id":"23645327-11038219-110623633","span":{"begin":232,"end":234},"obj":"11038219"},{"id":"23645327-732918-110623634","span":{"begin":235,"end":238},"obj":"732918"},{"id":"23645327-732918-110623634","span":{"begin":235,"end":238},"obj":"732918"},{"id":"23645327-25580-110623635","span":{"begin":239,"end":242},"obj":"25580"},{"id":"23645327-25580-110623635","span":{"begin":239,"end":242},"obj":"25580"},{"id":"23645327-17590169-110623636","span":{"begin":243,"end":246},"obj":"17590169"},{"id":"23645327-17590169-110623636","span":{"begin":243,"end":246},"obj":"17590169"},{"id":"23645327-8097874-110623637","span":{"begin":251,"end":254},"obj":"8097874"},{"id":"23645327-8097874-110623637","span":{"begin":251,"end":254},"obj":"8097874"},{"id":"23645327-2574567-110623638","span":{"begin":255,"end":258},"obj":"2574567"},{"id":"23645327-2574567-110623638","span":{"begin":255,"end":258},"obj":"2574567"},{"id":"23645327-14641000-110623639","span":{"begin":417,"end":420},"obj":"14641000"},{"id":"23645327-14641000-110623639","span":{"begin":417,"end":420},"obj":"14641000"},{"id":"23645327-19949948-110623640","span":{"begin":421,"end":424},"obj":"19949948"},{"id":"23645327-19949948-110623640","span":{"begin":421,"end":424},"obj":"19949948"},{"id":"23645327-1677802-110623641","span":{"begin":425,"end":428},"obj":"1677802"},{"id":"23645327-1677802-110623641","span":{"begin":425,"end":428},"obj":"1677802"},{"id":"23645327-8105768-110623642","span":{"begin":429,"end":432},"obj":"8105768"},{"id":"23645327-8105768-110623642","span":{"begin":429,"end":432},"obj":"8105768"},{"id":"23645327-17766710-110623643","span":{"begin":433,"end":436},"obj":"17766710"},{"id":"23645327-17766710-110623643","span":{"begin":433,"end":436},"obj":"17766710"},{"id":"23645327-8099273-110623644","span":{"begin":437,"end":440},"obj":"8099273"},{"id":"23645327-8099273-110623644","span":{"begin":437,"end":440},"obj":"8099273"},{"id":"23645327-9922308-68447087","span":{"begin":229,"end":231},"obj":"9922308"},{"id":"23645327-9922308-68447087","span":{"begin":229,"end":231},"obj":"9922308"},{"id":"23645327-11038219-68447088","span":{"begin":232,"end":234},"obj":"11038219"},{"id":"23645327-11038219-68447088","span":{"begin":232,"end":234},"obj":"11038219"},{"id":"23645327-732918-68447089","span":{"begin":235,"end":238},"obj":"732918"},{"id":"23645327-732918-68447089","span":{"begin":235,"end":238},"obj":"732918"},{"id":"23645327-25580-68447090","span":{"begin":239,"end":242},"obj":"25580"},{"id":"23645327-25580-68447090","span":{"begin":239,"end":242},"obj":"25580"},{"id":"23645327-17590169-68447091","span":{"begin":243,"end":246},"obj":"17590169"},{"id":"23645327-17590169-68447091","span":{"begin":243,"end":246},"obj":"17590169"},{"id":"23645327-8097874-68447092","span":{"begin":251,"end":254},"obj":"8097874"},{"id":"23645327-8097874-68447092","span":{"begin":251,"end":254},"obj":"8097874"},{"id":"23645327-2574567-68447093","span":{"begin":255,"end":258},"obj":"2574567"},{"id":"23645327-2574567-68447093","span":{"begin":255,"end":258},"obj":"2574567"},{"id":"23645327-14641000-68447094","span":{"begin":417,"end":420},"obj":"14641000"},{"id":"23645327-14641000-68447094","span":{"begin":417,"end":420},"obj":"14641000"},{"id":"23645327-19949948-68447095","span":{"begin":421,"end":424},"obj":"19949948"},{"id":"23645327-19949948-68447095","span":{"begin":421,"end":424},"obj":"19949948"},{"id":"23645327-1677802-68447096","span":{"begin":425,"end":428},"obj":"1677802"},{"id":"23645327-1677802-68447096","span":{"begin":425,"end":428},"obj":"1677802"},{"id":"23645327-8105768-68447097","span":{"begin":429,"end":432},"obj":"8105768"},{"id":"23645327-8105768-68447097","span":{"begin":429,"end":432},"obj":"8105768"},{"id":"23645327-17766710-68447098","span":{"begin":433,"end":436},"obj":"17766710"},{"id":"23645327-17766710-68447098","span":{"begin":433,"end":436},"obj":"17766710"},{"id":"23645327-8099273-68447099","span":{"begin":437,"end":440},"obj":"8099273"},{"id":"23645327-8099273-68447099","span":{"begin":437,"end":440},"obj":"8099273"}],"text":"In our 2 series (the NIH and pooled literature series), death due to a malignant PET was most frequently due to a malignant gastrinoma (60% and 100% of cases). This result is similar to that reported in 6 series in the literature54,78,224,226,251,289,367,444 where the percentage of malignant gastrinomas responsible for the PET-related malignant deaths could be assessed; however, it differs from results in 4 series129,150,378,379,448,465 wherein malignant gastrinomas were responsible for only an average of 16% (range, 0–38%) of the malignant PET deaths. It is unclear from the data available in these latter reports whether this low percentage of malignant gastrinomas contributing to the overall number of malignant PETs is clearly reflective of the actual findings in these patients, because in most of these series the specific nature of the malignant PET is poorly described. Therefore, while our data and most recent literature series clearly establish that the malignant nature of the PET is now the leading cause of death in MEN1 patients, it is not clearly established what type of PET is responsible for this, particularly whether the majority of these malignant PETs are nonfunctional PETs or gastrinomas."}