PMC:3727638 / 49783-50890 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3727638","sourcedb":"PMC","sourceid":"3727638","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3727638","text":"We carried out a similar analysis to identify possible prognostic factors determining an MEN1-related death in the 227 MEN1/PET patients from the pooled literature (Table 9). For various MEN1 features there was no significant difference between the percentage of patients who died from an MEN1-related or unrelated cause, including HPT (95% vs 96%, respectively); pituitary disease (23% vs 20%); adrenal abnormality (8.9% vs 8.7%); ZES (66% vs 75%); another functional PET (22% vs 17%); a nonfunctional PET (29% vs 18%); or a CNS, skin, or smooth muscle tumor (0–3.5%). In contrast, MEN1/PET patients from the pooled literature with an MEN1-related death more frequently had a carcinoid tumor (26% vs 9%, p = 0.0048), and in particular a thymic carcinoid tumor (22% vs 3.3%, p = 0.006) but not a gastric, lung, or intestinal carcinoid. Almost reaching significance was the presence of PETs other than gastrinomas in patients with an MEN1-related death (47% vs 33%, p = 0.058), whereas thyroid disease showed a trend toward higher occurrence in patients with a non-MEN1-related death (0 vs 2.95%, p = 0.050).","tracks":[]}