PMC:3727638 / 3951-4653 JSONTXT

{"project":"2_test","denotations":[{"id":"23645327-6152202-110622632","span":{"begin":133,"end":136},"obj":"6152202"},{"id":"23645327-6152202-110622632","span":{"begin":133,"end":136},"obj":"6152202"},{"id":"23645327-11033760-110622633","span":{"begin":137,"end":140},"obj":"11033760"},{"id":"23645327-11033760-110622633","span":{"begin":137,"end":140},"obj":"11033760"},{"id":"23645327-9103196-110622634","span":{"begin":348,"end":350},"obj":"9103196"},{"id":"23645327-9103196-110622634","span":{"begin":348,"end":350},"obj":"9103196"},{"id":"23645327-18798544-110622635","span":{"begin":351,"end":354},"obj":"18798544"},{"id":"23645327-18798544-110622635","span":{"begin":351,"end":354},"obj":"18798544"},{"id":"23645327-20833329-110622636","span":{"begin":355,"end":358},"obj":"20833329"},{"id":"23645327-20833329-110622636","span":{"begin":355,"end":358},"obj":"20833329"},{"id":"23645327-6152202-68446176","span":{"begin":133,"end":136},"obj":"6152202"},{"id":"23645327-6152202-68446176","span":{"begin":133,"end":136},"obj":"6152202"},{"id":"23645327-11033760-68446177","span":{"begin":137,"end":140},"obj":"11033760"},{"id":"23645327-11033760-68446177","span":{"begin":137,"end":140},"obj":"11033760"},{"id":"23645327-9103196-68446178","span":{"begin":348,"end":350},"obj":"9103196"},{"id":"23645327-9103196-68446178","span":{"begin":348,"end":350},"obj":"9103196"},{"id":"23645327-18798544-68446179","span":{"begin":351,"end":354},"obj":"18798544"},{"id":"23645327-18798544-68446179","span":{"begin":351,"end":354},"obj":"18798544"},{"id":"23645327-20833329-68446180","span":{"begin":355,"end":358},"obj":"20833329"},{"id":"23645327-20833329-68446180","span":{"begin":355,"end":358},"obj":"20833329"},{"id":"23645327-16997566-68446181","span":{"begin":685,"end":687},"obj":"16997566"},{"id":"23645327-16997566-68446181","span":{"begin":685,"end":687},"obj":"16997566"},{"id":"23645327-17940620-68446182","span":{"begin":688,"end":690},"obj":"17940620"},{"id":"23645327-17940620-68446182","span":{"begin":688,"end":690},"obj":"17940620"},{"id":"23645327-18798544-68446183","span":{"begin":691,"end":694},"obj":"18798544"},{"id":"23645327-18798544-68446183","span":{"begin":691,"end":694},"obj":"18798544"},{"id":"23645327-20833329-68446184","span":{"begin":695,"end":698},"obj":"20833329"},{"id":"23645327-20833329-68446184","span":{"begin":695,"end":698},"obj":"20833329"},{"id":"23645327-20833329-68446184","span":{"begin":695,"end":698},"obj":"20833329"},{"id":"23645327-20833329-68446184","span":{"begin":695,"end":698},"obj":"20833329"}],"text":"The autosomal dominant disorder, multiple endocrine neoplasia type 1 (MEN1) has an incidence of 0.22%–0.25% in postmortem studies.32,239,418 MEN1 is caused by alterations in the 10 exon Menin gene located on chromosome 11q13, which result in abnormalities (mutations, deletions, truncations, primarily) in the 610 amino acid nuclear protein, menin.62,195,419 Although the exact mechanisms by which altered or absent menin causes the clinicopathologic changes characteristic of MEN1 are not known, numerous studies have demonstrated that menin is involved in many important cellular processes such as cell cycle regulation, transcriptional control, cell division, and genomic stability.16,50,195,419,469"}