PMC:3724992 / 12588-13447 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3724992","sourcedb":"PMC","sourceid":"3724992","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3724992","text":"The binding affinity and stability of these peptides to HLA-A2.1 was determined by using antigen processing-deficient T2 cells because their enhanced HLA-A2.1. As shown in Table 2, all of the peptides synthesized were bound to HLA-A2.1 molecules but with different affinity and stability. Of four peptides selected, neuritin13–21 up-regulated the HLA-A2.1 molecular expression and showed high affinity and stability to HLA-A2.1, whereas neuritin121–129 and neuritin4–12 showed moderate affinity and neuritin127–135 only had low affinity and stability to the molecule.\nTable 2 HLA-A2-binding affinity and stability of neuritin-derived peptides\nPosition Length Sequence FI DC50\n13–21 9 ILAVQIAYL 1.68 \u003e8\n121–129 9 LLPAFPVLL 1.24 6–8\n4–12 9 KLNGRYISL 1.07 6–8\n127–135 9 VLLVSLSAA 0.68 2–4\n519–526 9 FSYGFFV 0.38 \u003c2\nThe shaded region is the control peptide values","divisions":[{"label":"label","span":{"begin":568,"end":575}},{"label":"caption","span":{"begin":576,"end":642}},{"label":"p","span":{"begin":576,"end":642}},{"label":"table","span":{"begin":643,"end":811}},{"label":"tr","span":{"begin":643,"end":675}},{"label":"th","span":{"begin":643,"end":651}},{"label":"th","span":{"begin":652,"end":658}},{"label":"th","span":{"begin":659,"end":667}},{"label":"th","span":{"begin":668,"end":670}},{"label":"th","span":{"begin":671,"end":675}},{"label":"tr","span":{"begin":676,"end":701}},{"label":"td","span":{"begin":676,"end":681}},{"label":"td","span":{"begin":682,"end":683}},{"label":"td","span":{"begin":684,"end":693}},{"label":"td","span":{"begin":694,"end":698}},{"label":"td","span":{"begin":699,"end":701}},{"label":"tr","span":{"begin":702,"end":730}},{"label":"td","span":{"begin":702,"end":709}},{"label":"td","span":{"begin":710,"end":711}},{"label":"td","span":{"begin":712,"end":721}},{"label":"td","span":{"begin":722,"end":726}},{"label":"td","span":{"begin":727,"end":730}},{"label":"tr","span":{"begin":731,"end":756}},{"label":"td","span":{"begin":731,"end":735}},{"label":"td","span":{"begin":736,"end":737}},{"label":"td","span":{"begin":738,"end":747}},{"label":"td","span":{"begin":748,"end":752}},{"label":"td","span":{"begin":753,"end":756}},{"label":"tr","span":{"begin":757,"end":785}},{"label":"td","span":{"begin":757,"end":764}},{"label":"td","span":{"begin":765,"end":766}},{"label":"td","span":{"begin":767,"end":776}},{"label":"td","span":{"begin":777,"end":781}},{"label":"td","span":{"begin":782,"end":785}},{"label":"tr","span":{"begin":786,"end":811}},{"label":"td","span":{"begin":786,"end":793}},{"label":"td","span":{"begin":794,"end":795}},{"label":"td","span":{"begin":796,"end":803}},{"label":"td","span":{"begin":804,"end":808}},{"label":"td","span":{"begin":809,"end":811}}],"tracks":[]}