PMC:3724992 / 1220-2432
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3724992","sourcedb":"PMC","sourceid":"3724992","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3724992","text":"Introduction\nAstrocytoma is a common malignant primary brain tumor with a poor clinical prognosis in both adults and children [1–3]. The therapeutic options for the treatment of patients with astrocytoma are limited to three fundamental modalities: surgical resection, chemotherapy, and radiation therapy [4–6]. Cellular adoptive immunotherapy with specific CTLs has been recently used to treat malignant tumors [7–9].\nNeuritin has been cloned and characterized as an important neurotrophin [10]. Recently, neuritin expression was found in astrocytomas and the expression level increased with astrocytoma pathologic grade, indicating that neuritin has an important role both in the promotion and in the progression of astrocytomas [11].\nAnti-tumor vaccination is based on the existence of antigens, selectively or preferentially expressed by tumors, called tumor-associated antigens (TAAs) [12–14]. Vaccination with peptides derived from TAAs designed to stimulate specific T-cells is being a practicable approach evaluated in clinical trials [15–17]. To investigate the immune response elicited by neuritin CTL epitopes, the present study was undertaken to identify candidate CTL epitopes derived from neuritin.","divisions":[{"label":"title","span":{"begin":0,"end":12}},{"label":"p","span":{"begin":13,"end":418}},{"label":"p","span":{"begin":419,"end":736}}],"tracks":[{"project":"2_test","denotations":[{"id":"23754640-19336457-63236733","span":{"begin":127,"end":128},"obj":"19336457"},{"id":"23754640-18182667-63236733","span":{"begin":127,"end":128},"obj":"18182667"},{"id":"23754640-18093251-63236733","span":{"begin":127,"end":128},"obj":"18093251"},{"id":"23754640-19215696-63236734","span":{"begin":306,"end":307},"obj":"19215696"},{"id":"23754640-18953491-63236734","span":{"begin":306,"end":307},"obj":"18953491"},{"id":"23754640-19766005-63236734","span":{"begin":306,"end":307},"obj":"19766005"},{"id":"23754640-19895242-63236735","span":{"begin":413,"end":414},"obj":"19895242"},{"id":"23754640-18483377-63236735","span":{"begin":413,"end":414},"obj":"18483377"},{"id":"23754640-18259692-63236735","span":{"begin":413,"end":414},"obj":"18259692"},{"id":"23754640-20405246-63236736","span":{"begin":732,"end":734},"obj":"20405246"},{"id":"23754640-18438665-63236737","span":{"begin":891,"end":893},"obj":"18438665"},{"id":"23754640-16530303-63236737","span":{"begin":891,"end":893},"obj":"16530303"},{"id":"23754640-18302222-63236737","span":{"begin":891,"end":893},"obj":"18302222"},{"id":"23754640-19545862-63236738","span":{"begin":1044,"end":1046},"obj":"19545862"},{"id":"23754640-19505380-63236738","span":{"begin":1044,"end":1046},"obj":"19505380"},{"id":"23754640-19445013-63236738","span":{"begin":1044,"end":1046},"obj":"19445013"}],"attributes":[{"subj":"23754640-19336457-63236733","pred":"source","obj":"2_test"},{"subj":"23754640-18182667-63236733","pred":"source","obj":"2_test"},{"subj":"23754640-18093251-63236733","pred":"source","obj":"2_test"},{"subj":"23754640-19215696-63236734","pred":"source","obj":"2_test"},{"subj":"23754640-18953491-63236734","pred":"source","obj":"2_test"},{"subj":"23754640-19766005-63236734","pred":"source","obj":"2_test"},{"subj":"23754640-19895242-63236735","pred":"source","obj":"2_test"},{"subj":"23754640-18483377-63236735","pred":"source","obj":"2_test"},{"subj":"23754640-18259692-63236735","pred":"source","obj":"2_test"},{"subj":"23754640-20405246-63236736","pred":"source","obj":"2_test"},{"subj":"23754640-18438665-63236737","pred":"source","obj":"2_test"},{"subj":"23754640-16530303-63236737","pred":"source","obj":"2_test"},{"subj":"23754640-18302222-63236737","pred":"source","obj":"2_test"},{"subj":"23754640-19545862-63236738","pred":"source","obj":"2_test"},{"subj":"23754640-19505380-63236738","pred":"source","obj":"2_test"},{"subj":"23754640-19445013-63236738","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93b9","default":true}]}]}}