PMC:3724972 / 6015-6802 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3724972","sourcedb":"PMC","sourceid":"3724972","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3724972","text":"These findings have produced a working model of the regulation of ACTH secretion by corticotroph adenomas [31, 32], wherein high systemic cortisol downregulates sstr2 expression in the corticotroph adenoma cells, rendering sstr2 agonists ineffective at inhibiting ACTH secretion. In contrast, sstr5 expression appears to be relatively unaffected by high cortisol levels. Upon treatment with an sstr5 agonist, ACTH secretion is reduced, leading to declines in cortisol secretion from the adrenal glands. This model is supported by evidence from murine AtT20 cells, a corticotroph cell line. Treatment of AtT20 cells with dexamethasone reduced expression of sstr2 mRNA without significantly affecting sstr5 mRNA expression or the ability of an sstr5 agonist to inhibit ACTH secretion [33].","tracks":[{"project":"2_test","denotations":[{"id":"23673515-18221833-63233602","span":{"begin":107,"end":109},"obj":"18221833"},{"id":"23673515-17413188-63233603","span":{"begin":111,"end":113},"obj":"17413188"},{"id":"23673515-15769796-63233604","span":{"begin":783,"end":785},"obj":"15769796"}],"attributes":[{"subj":"23673515-18221833-63233602","pred":"source","obj":"2_test"},{"subj":"23673515-17413188-63233603","pred":"source","obj":"2_test"},{"subj":"23673515-15769796-63233604","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d1ec93","default":true}]}]}}