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    2_test

    {"project":"2_test","denotations":[{"id":"23673515-10433861-63233585","span":{"begin":119,"end":121},"obj":"10433861"},{"id":"23673515-8243278-63233586","span":{"begin":235,"end":237},"obj":"8243278"},{"id":"23673515-12502754-63233587","span":{"begin":239,"end":241},"obj":"12502754"},{"id":"23673515-10433861-63233588","span":{"begin":340,"end":342},"obj":"10433861"},{"id":"23673515-15281350-63233589","span":{"begin":486,"end":488},"obj":"15281350"},{"id":"23673515-22976314-63233589","span":{"begin":486,"end":488},"obj":"22976314"},{"id":"23673515-15817922-63233589","span":{"begin":486,"end":488},"obj":"15817922"},{"id":"23673515-15281350-63233590","span":{"begin":619,"end":621},"obj":"15281350"},{"id":"23673515-15817922-63233591","span":{"begin":623,"end":625},"obj":"15817922"},{"id":"23673515-16940446-63233592","span":{"begin":821,"end":823},"obj":"16940446"}],"text":"Somatostatin often serves to inhibit secretory responses, but also exhibits antiproliferative effects in some tissues [14]. Somatostatin receptors are widespread throughout the central nervous system and in several peripheral tissues [15, 16]. To date, 5 somatostatin receptor subtypes (sstr) have been identified and cloned (sstr1–sstr5) [14]. Immunostaining indicates that normal human anterior pituitary expresses all 5 subtypes, and that most corticotroph adenomas express ≥1 sstr [17–19]. While expression levels are highly variable, sstr2 and sstr5 are most consistently expressed, and sstr4 is generally absent [17, 19]. A study using quantitative RT-PCR and immunohistochemistry found that human corticotroph adenomas expressed sstr1,2,4 and 5, and that sstr5 had the highest expression levels in 10/12 adenomas [20]."}