PMC:3724972 / 23527-24311 JSONTXT

{"project":"2_test","denotations":[{"id":"23673515-11602619-63233669","span":{"begin":501,"end":503},"obj":"11602619"},{"id":"23673515-16195406-63233670","span":{"begin":638,"end":640},"obj":"16195406"},{"id":"23673515-16740975-63233671","span":{"begin":780,"end":782},"obj":"16740975"}],"text":"The retinoic acid receptor is a type II nuclear receptor involved with transcriptional regulation. In a murine corticotrope tumor cell line, retinoic acid has been shown to reduce ACTH secretion and pro-opiomelanocortin (POMC) synthesis. Further, there is evidence that, with prolonged treatment, retinoic acid induces increased caspase-3 activity and cell death in ACTH-secreting cells. It has also demonstrated inhibition of corticosterone production and cell proliferation in adrenal cortex cells [69]. Retinoic acid had demonstrated reduced ACTH secretion and prevented tumor growth in mice with implanted with tumoral corticotropes [70]. In a 6-month study in dogs with spontaneous corticotrope tumors, retinoic acid reduced cortisol excess and improved associated symptoms [71]."}