PMC:3724972 / 20255-21318 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3724972","sourcedb":"PMC","sourceid":"3724972","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3724972","text":"Table 2 Medical treatments for Cushing’s disease evaluated in prospective clinical studies\nCompound Trial Patients (N) Treatment duration Outcome\nPasireotide Boscaro et al. [40] 29 15 days 5/29 patients (17 %) achieved UFC ≤ ULN; 22/29 patients (76 %) experienced reduction in mean UFC\nColao et al. [43] 162 12 months 33/162 patients (20 %) achieved UFC ≤ ULN within 6 months without increase from randomized dose; the majority of patients experienced reduction in UFC at month 6, sustained through month 12\nCabergoline Lila et al. [52] 18 5 months 5 patients (28 %) achieved MNSC \u003c5 μg/dL or low-dose dexamethasone-suppressed serum cortisol \u003c1.8 μg/dL\nPivonello et al. [48, 53] 20 3–24 months After 3 months, 15 patients (75 %) achieved UFC ≤ ULN or ≥25 % reduction from baseline; 8 patients (40 %) maintained UFC ≤ ULN at 24 months\nRetinoic acid Pecori Girald et al. [59] 7 6–12 months 3/7 patients (43 %) achieved UFC ≤ ULN; 5/7 patients (71 %) experienced reduction in UFC\nMNSC midnight salivary cortisol, UFC urinary free cortisol, ULN upper limit of normal\n","divisions":[{"label":"label","span":{"begin":0,"end":7}},{"label":"caption","span":{"begin":8,"end":90}},{"label":"p","span":{"begin":8,"end":90}},{"label":"table","span":{"begin":91,"end":976}},{"label":"tr","span":{"begin":91,"end":145}},{"label":"th","span":{"begin":91,"end":99}},{"label":"th","span":{"begin":100,"end":105}},{"label":"th","span":{"begin":106,"end":118}},{"label":"th","span":{"begin":119,"end":137}},{"label":"th","span":{"begin":138,"end":145}},{"label":"tr","span":{"begin":146,"end":285}},{"label":"td","span":{"begin":146,"end":157}},{"label":"td","span":{"begin":158,"end":177}},{"label":"td","span":{"begin":178,"end":180}},{"label":"td","span":{"begin":181,"end":188}},{"label":"td","span":{"begin":189,"end":285}},{"label":"tr","span":{"begin":286,"end":507}},{"label":"td","span":{"begin":286,"end":303}},{"label":"td","span":{"begin":304,"end":307}},{"label":"td","span":{"begin":308,"end":317}},{"label":"td","span":{"begin":318,"end":507}},{"label":"tr","span":{"begin":508,"end":652}},{"label":"td","span":{"begin":508,"end":519}},{"label":"td","span":{"begin":520,"end":536}},{"label":"td","span":{"begin":537,"end":539}},{"label":"td","span":{"begin":540,"end":548}},{"label":"td","span":{"begin":549,"end":652}},{"label":"tr","span":{"begin":653,"end":833}},{"label":"td","span":{"begin":653,"end":678}},{"label":"td","span":{"begin":679,"end":681}},{"label":"td","span":{"begin":682,"end":693}},{"label":"td","span":{"begin":694,"end":833}},{"label":"tr","span":{"begin":834,"end":976}},{"label":"td","span":{"begin":834,"end":847}},{"label":"td","span":{"begin":848,"end":873}},{"label":"td","span":{"begin":874,"end":875}},{"label":"td","span":{"begin":876,"end":887}},{"label":"td","span":{"begin":888,"end":976}}],"tracks":[{"project":"2_test","denotations":[{"id":"23673515-18957506-63233650","span":{"begin":174,"end":176},"obj":"18957506"},{"id":"23673515-22397653-63233651","span":{"begin":300,"end":302},"obj":"22397653"},{"id":"23673515-20497937-63233652","span":{"begin":533,"end":535},"obj":"20497937"},{"id":"23673515-15126577-63233653","span":{"begin":671,"end":673},"obj":"15126577"},{"id":"23673515-18957500-63233654","span":{"begin":675,"end":677},"obj":"18957500"},{"id":"23673515-22851491-63233655","span":{"begin":870,"end":872},"obj":"22851491"}],"attributes":[{"subj":"23673515-18957506-63233650","pred":"source","obj":"2_test"},{"subj":"23673515-22397653-63233651","pred":"source","obj":"2_test"},{"subj":"23673515-20497937-63233652","pred":"source","obj":"2_test"},{"subj":"23673515-15126577-63233653","pred":"source","obj":"2_test"},{"subj":"23673515-18957500-63233654","pred":"source","obj":"2_test"},{"subj":"23673515-22851491-63233655","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93ec","default":true}]}]}}