PMC:3681796 / 30000-31583 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3681796","sourcedb":"PMC","sourceid":"3681796","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3681796","text":"10.1371/journal.pone.0064525.g006 Figure 6 Muscle function recovery in SCD-deficient mice submitted to nerve crush.\nRestoration of muscle grip strength in SCD1 knockout mice (A) or MF-438 treated mice (C) (black circles) and corresponding control littermates (white circles) at the indicated post-operation times. ***P\u003c0.001 (2-way ANOVA, n = 4–12). Percentage of electromyography episodes of spontaneous activity in SCD1 knockout mice (Inset A) or MF-438 treated mice (Inset C) (KO or MF, brown columns) and corresponding control littermates (WT or CT, white columns) two weeks after sciatic nerve crush. *P\u003c0.05 (Unpaired t-test, n = 4–7). (B) Relative density of muscle fiber types in ipsilateral and contralateral tibialis anterior from SCD1 knockout mice and wild-type littermates two weeks after sciatic nerve crush. According to SDH histochemistry, fibers were classified as dark brown colored fibers with high metabolic oxidative capacity (brown columns), pale brown colored fibers with medium oxidative capacity (orange columns) and non-satined fibers (white columns). *P\u003c0.05 and ***P\u003c0.001 (1-way ANOVA followed by Tukey's multiple comparison test, (n = 4–6). (D) Kaplan-Meier curves showing the percentage of MF-438 treated mice (black circles) and control littermates (white circles) that started to exhibit a grip strength distinct from zero after initial total paralysis. Logrank test (n = 10–11). Inset D, averaged time at start of recovery in MF-438 treated mice (MF, brown column) and control littermates (CT, white column). *P\u003c0.05 (Unpaired t-test, n = 10–11).\n\n","divisions":[{"label":"Title","span":{"begin":44,"end":116}}],"tracks":[]}