PMC:3660126 / 10037-11744 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3660126","sourcedb":"PMC","sourceid":"3660126","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3660126","text":"Role of CAM in mood disorders\nComplementary and alternative medicine is the most practiced but least researched form of treatment because of the complexities inherent in assessment of its effectiveness in major depression and other mood disorders. These complexities include solo versus adjunctive treatments, the multiple facets of depression, design and methodological issues, and use of herbs with unknown bioactive ingredients. To address this conundrum, the Canadian Network Group has developed guidelines for the use of CAM in adults with major depression, suggesting efficacy using light therapy for seasonal affective disorder, St John’s wort for mild to moderate depression (level 1 evidence), and omega-3 fatty acids, yoga, exercise, sleep deprivation, and S-adenosylmethionine for major depression.37 Level 1 evidence is that obtained from at least one appropriately designed randomized controlled trial. The American Task Force has also reported promising results with regard to omega-3 fatty acids, St John’s wort, folate, S-adenosylmethionine, acupuncture, light therapy, exercise, and mindfulness psychotherapies in major depression.38 This report recommends the undertaking of more rigorous and larger studies in the future, and that each CAM treatment must be evaluated separately in adequately powered controlled trials. They suggested that further focus is needed on clinical, research, and educational initiatives with regard to CAM in psychiatry, and cautions that the greatest risk of pursuing CAM is possible delayed use of other well established treatments.38 Dutch researchers have also developed a protocol for ensuring safe and effective use of CAM in the mental health setting.39","divisions":[{"label":"Title","span":{"begin":0,"end":29}}],"tracks":[{"project":"NEUROSES","denotations":[{"id":"T289","span":{"begin":60,"end":68},"obj":"CHEBI_23888"},{"id":"T290","span":{"begin":314,"end":322},"obj":"PATO_0002118"},{"id":"T291","span":{"begin":480,"end":485},"obj":"CHEBI_24433"},{"id":"T292","span":{"begin":589,"end":594},"obj":"PATO_0000665"},{"id":"T293","span":{"begin":1071,"end":1076},"obj":"PATO_0000665"},{"id":"T294","span":{"begin":589,"end":594},"obj":"CHEBI_30212"},{"id":"T295","span":{"begin":1071,"end":1076},"obj":"CHEBI_30212"},{"id":"T296","span":{"begin":767,"end":787},"obj":"CHEBI_33442"},{"id":"T297","span":{"begin":1036,"end":1056},"obj":"CHEBI_33442"},{"id":"T298","span":{"begin":767,"end":787},"obj":"CHEBI_15414"},{"id":"T299","span":{"begin":1036,"end":1056},"obj":"CHEBI_15414"},{"id":"T300","span":{"begin":767,"end":787},"obj":"CHEBI_67040"},{"id":"T301","span":{"begin":1036,"end":1056},"obj":"CHEBI_67040"},{"id":"T302","span":{"begin":934,"end":939},"obj":"PATO_0001035"},{"id":"T303","span":{"begin":1028,"end":1034},"obj":"CHEBI_27470"},{"id":"T304","span":{"begin":1028,"end":1034},"obj":"CHEBI_67011"},{"id":"T305","span":{"begin":1028,"end":1034},"obj":"CHEBI_62501"},{"id":"T306","span":{"begin":1028,"end":1034},"obj":"CHEBI_37445"},{"id":"T307","span":{"begin":1367,"end":1372},"obj":"PATO_0001516"},{"id":"T308","span":{"begin":1532,"end":1539},"obj":"PATO_0000502"},{"id":"T309","span":{"begin":211,"end":221},"obj":"PM3425"},{"id":"T310","span":{"begin":333,"end":343},"obj":"PM3425"},{"id":"T311","span":{"begin":551,"end":561},"obj":"PM3425"},{"id":"T312","span":{"begin":672,"end":682},"obj":"PM3425"},{"id":"T313","span":{"begin":798,"end":808},"obj":"PM3425"},{"id":"T314","span":{"begin":1137,"end":1147},"obj":"PM3425"},{"id":"T315","span":{"begin":211,"end":221},"obj":"PM3425"},{"id":"T316","span":{"begin":333,"end":343},"obj":"PM3425"},{"id":"T317","span":{"begin":551,"end":561},"obj":"PM3425"},{"id":"T318","span":{"begin":672,"end":682},"obj":"PM3425"},{"id":"T319","span":{"begin":798,"end":808},"obj":"PM3425"},{"id":"T320","span":{"begin":1137,"end":1147},"obj":"PM3425"},{"id":"T321","span":{"begin":655,"end":682},"obj":"PM5797"}],"attributes":[{"subj":"T289","pred":"source","obj":"NEUROSES"},{"subj":"T290","pred":"source","obj":"NEUROSES"},{"subj":"T291","pred":"source","obj":"NEUROSES"},{"subj":"T292","pred":"source","obj":"NEUROSES"},{"subj":"T293","pred":"source","obj":"NEUROSES"},{"subj":"T294","pred":"source","obj":"NEUROSES"},{"subj":"T295","pred":"source","obj":"NEUROSES"},{"subj":"T296","pred":"source","obj":"NEUROSES"},{"subj":"T297","pred":"source","obj":"NEUROSES"},{"subj":"T298","pred":"source","obj":"NEUROSES"},{"subj":"T299","pred":"source","obj":"NEUROSES"},{"subj":"T300","pred":"source","obj":"NEUROSES"},{"subj":"T301","pred":"source","obj":"NEUROSES"},{"subj":"T302","pred":"source","obj":"NEUROSES"},{"subj":"T303","pred":"source","obj":"NEUROSES"},{"subj":"T304","pred":"source","obj":"NEUROSES"},{"subj":"T305","pred":"source","obj":"NEUROSES"},{"subj":"T306","pred":"source","obj":"NEUROSES"},{"subj":"T307","pred":"source","obj":"NEUROSES"},{"subj":"T308","pred":"source","obj":"NEUROSES"},{"subj":"T309","pred":"source","obj":"NEUROSES"},{"subj":"T310","pred":"source","obj":"NEUROSES"},{"subj":"T311","pred":"source","obj":"NEUROSES"},{"subj":"T312","pred":"source","obj":"NEUROSES"},{"subj":"T313","pred":"source","obj":"NEUROSES"},{"subj":"T314","pred":"source","obj":"NEUROSES"},{"subj":"T315","pred":"source","obj":"NEUROSES"},{"subj":"T316","pred":"source","obj":"NEUROSES"},{"subj":"T317","pred":"source","obj":"NEUROSES"},{"subj":"T318","pred":"source","obj":"NEUROSES"},{"subj":"T319","pred":"source","obj":"NEUROSES"},{"subj":"T320","pred":"source","obj":"NEUROSES"},{"subj":"T321","pred":"source","obj":"NEUROSES"}]},{"project":"2_test","denotations":[{"id":"23700366-19666194-76000587","span":{"begin":809,"end":811},"obj":"19666194"},{"id":"23700366-20573326-76000588","span":{"begin":1148,"end":1150},"obj":"20573326"},{"id":"23700366-20573326-76000589","span":{"begin":1581,"end":1583},"obj":"20573326"}],"attributes":[{"subj":"23700366-19666194-76000587","pred":"source","obj":"2_test"},{"subj":"23700366-20573326-76000588","pred":"source","obj":"2_test"},{"subj":"23700366-20573326-76000589","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#93eca3","default":true},{"id":"2_test","color":"#ec939c"}]}]}}