PMC:3656366 / 10027-10599 JSONTXT

{"project":"NEUROSES","denotations":[{"id":"T212","span":{"begin":33,"end":44},"obj":"PATO_0000085"},{"id":"T213","span":{"begin":64,"end":78},"obj":"CHEBI_35469"},{"id":"T214","span":{"begin":111,"end":120},"obj":"CHEBI_28790"},{"id":"T215","span":{"begin":111,"end":120},"obj":"CHEBI_350546"},{"id":"T216","span":{"begin":130,"end":140},"obj":"CHEBI_35222"}],"text":"Experiments\nIn Experiment 1, the sensitivity of HAB mice to the antidepressant efficacy of different selective serotonin reuptake inhibitors (SSRIs) was explored in the forced swim test (FST) (Figure 1). Experiments 2–4 (Figure 2a) were designed to investigate the effect of single and repeated NAcb-DBS (i) on the anxiety- and depression-related behavior displayed by HAB mice, using a battery of established tests, (ii) on adult hippocampal neurogenesis, and (iii) on challenge-induced neuronal activation patterns in different brain regions, using immunohistochemistry."}