PMC:3598541 / 8564-9700
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3598541","sourcedb":"PMC","sourceid":"3598541","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3598541","text":"Secondary objectives\nSecondary objectives of this study comprise to evaluate \n• Whether methylphenidate immediate release given BID is significantly superior to placebo in the treatment of manic symptoms in patients with bipolar disorder after 2 hours of treatment as assessed by the YMRS and the Positive and Negative Syndrome scale - excited component (PANSS-EC) [42].\n• The change from baseline to endpoint (after 2.5 days of treatment) on the Clinical Global Impression-Bipolar Scale CGI-BP [43] and the PANSS-EC.\n• Whether 2.5 days of treatment with methylphenidate but not with placebo stabilise vigilance regulation as assessed by the ‘Vigilance Algorithm Leipzig’ (VIGALL) [44].\nWhether instability of vigilance regulation as assessed by the VIGALL predicts response to methylphenidate.\n• Whether methylphenidate immediate release given BID is associated with significantly less movements over the study period than placebo as assessed by actigraphy.\n• Whether methylphenidate is significantly superior to placebo in improving cognitive performance as assessed by the “Screen for Cognitive Impairment in Psychiatry” (SCIP) [45].","divisions":[{"label":"Title","span":{"begin":0,"end":20}}],"tracks":[{"project":"NEUROSES","denotations":[{"id":"T132","span":{"begin":0,"end":9},"obj":"PATO_0002532"},{"id":"T133","span":{"begin":21,"end":30},"obj":"PATO_0002532"},{"id":"T134","span":{"begin":88,"end":103},"obj":"CHEBI_6887"},{"id":"T135","span":{"begin":555,"end":570},"obj":"CHEBI_6887"},{"id":"T136","span":{"begin":778,"end":793},"obj":"CHEBI_6887"},{"id":"T137","span":{"begin":805,"end":820},"obj":"CHEBI_6887"},{"id":"T138","span":{"begin":969,"end":984},"obj":"CHEBI_6887"},{"id":"T139","span":{"begin":612,"end":622},"obj":"PATO_0000076"},{"id":"T140","span":{"begin":720,"end":730},"obj":"PATO_0000076"},{"id":"T141","span":{"begin":912,"end":918},"obj":"PATO_0001309"}],"attributes":[{"subj":"T132","pred":"source","obj":"NEUROSES"},{"subj":"T133","pred":"source","obj":"NEUROSES"},{"subj":"T134","pred":"source","obj":"NEUROSES"},{"subj":"T135","pred":"source","obj":"NEUROSES"},{"subj":"T136","pred":"source","obj":"NEUROSES"},{"subj":"T137","pred":"source","obj":"NEUROSES"},{"subj":"T138","pred":"source","obj":"NEUROSES"},{"subj":"T139","pred":"source","obj":"NEUROSES"},{"subj":"T140","pred":"source","obj":"NEUROSES"},{"subj":"T141","pred":"source","obj":"NEUROSES"}]},{"project":"2_test","denotations":[{"id":"23446109-21447155-13886230","span":{"begin":366,"end":368},"obj":"21447155"},{"id":"23446109-19110062-13886231","span":{"begin":682,"end":684},"obj":"19110062"}],"attributes":[{"subj":"23446109-21447155-13886230","pred":"source","obj":"2_test"},{"subj":"23446109-19110062-13886231","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#d0ec93","default":true},{"id":"2_test","color":"#ec93ea"}]}]}}